ID G0J6D3_CYCMS Unreviewed; 203 AA.
AC G0J6D3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=Biofilm operon icaADBC HTH-type negative transcriptional regulator IcaR {ECO:0000256|ARBA:ARBA00014341};
DE AltName: Full=Intercellular adhesion protein R {ECO:0000256|ARBA:ARBA00030200};
GN OrderedLocusNames=Cycma_3919 {ECO:0000313|EMBL:AEL27628.1};
OS Cyclobacterium marinum (strain ATCC 25205 / DSM 745 / LMG 13164 / NCIMB
OS 1802) (Flectobacillus marinus).
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Cyclobacteriaceae;
OC Cyclobacterium.
OX NCBI_TaxID=880070 {ECO:0000313|EMBL:AEL27628.1, ECO:0000313|Proteomes:UP000001635};
RN [1] {ECO:0000313|Proteomes:UP000001635}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 25205 / DSM 745 / LMG 13164 / NCIMB 1802
RC {ECO:0000313|Proteomes:UP000001635};
RA Lucas S., Han J., Lapidus A., Bruce D., Goodwin L., Pitluck S., Peters L.,
RA Kyrpides N., Mavromatis K., Ivanova N., Ovchinnikova G., Chertkov O.,
RA Detter J.C., Tapia R., Han C., Land M., Hauser L., Markowitz V.,
RA Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Tindall B., Schuetze A.,
RA Brambilla E., Klenk H.-P., Eisen J.A.;
RT "The complete genome of Cyclobacterium marinum DSM 745.";
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Represses transcription of the icaADBC operon necessary for
CC biofilm production. {ECO:0000256|ARBA:ARBA00002291}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
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DR EMBL; CP002955; AEL27628.1; -; Genomic_DNA.
DR RefSeq; WP_014021913.1; NC_015914.1.
DR AlphaFoldDB; G0J6D3; -.
DR STRING; 880070.Cycma_3919; -.
DR KEGG; cmr:Cycma_3919; -.
DR eggNOG; COG1309; Bacteria.
DR HOGENOM; CLU_117110_0_0_10; -.
DR OrthoDB; 7618612at2; -.
DR Proteomes; UP000001635; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.357.10; Tetracycline Repressor, domain 2; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR001647; HTH_TetR.
DR InterPro; IPR041646; IcaR_C.
DR Pfam; PF18665; TetR_C_37; 1.
DR Pfam; PF00440; TetR_N; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS50977; HTH_TETR_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00335};
KW Reference proteome {ECO:0000313|Proteomes:UP000001635}.
FT DOMAIN 7..67
FT /note="HTH tetR-type"
FT /evidence="ECO:0000259|PROSITE:PS50977"
FT DNA_BIND 30..49
FT /note="H-T-H motif"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00335"
SQ SEQUENCE 203 AA; 24095 MW; 1B74C0EDD28F13E2 CRC64;
MKSNIRTVRK KEIIEGFYEL CKREGLENVS IAKIGKQLGM PPSLIMHYFS NKRLLVLGLI
DHILHQYQLI YKPILLKFEK ESSLDPILLV DRLFSREWNL LFDDGVFFSC YAFIFRDTTI
RNAYKKLHLK LRSTLKTILD KDKDLSQKDT DLLAEKIFVV IEGAYYYLSM IEEPKEYQRK
LDIFKNQVLE LIQMKQGVKH QEK
//
