ID G0MT20_CAEBE Unreviewed; 718 AA.
AC G0MT20;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=long-chain-fatty-acid--CoA ligase {ECO:0000256|ARBA:ARBA00026121};
DE EC=6.2.1.3 {ECO:0000256|ARBA:ARBA00026121};
GN Name=Cbn-acs-17 {ECO:0000313|EMBL:EGT43197.1};
GN ORFNames=CAEBREN_05276 {ECO:0000313|EMBL:EGT43197.1};
OS Caenorhabditis brenneri (Nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=135651 {ECO:0000313|Proteomes:UP000008068};
RN [1] {ECO:0000313|Proteomes:UP000008068}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB2801 {ECO:0000313|Proteomes:UP000008068};
RG Caenorhabditis brenneri Sequencing and Analysis Consortium;
RA Wilson R.K.;
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-
CC CoA + AMP + diphosphate; Xref=Rhea:RHEA:15421, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:57287, ChEBI:CHEBI:57560,
CC ChEBI:CHEBI:83139, ChEBI:CHEBI:456215; EC=6.2.1.3;
CC Evidence={ECO:0000256|ARBA:ARBA00024484};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:15422;
CC Evidence={ECO:0000256|ARBA:ARBA00024484};
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
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DR EMBL; GL379810; EGT43197.1; -; Genomic_DNA.
DR AlphaFoldDB; G0MT20; -.
DR STRING; 135651.G0MT20; -.
DR EnsemblMetazoa; CBN05276.1; CBN05276.1; WBGene00144001.
DR eggNOG; KOG1180; Eukaryota.
DR HOGENOM; CLU_000022_45_2_1; -.
DR InParanoid; G0MT20; -.
DR OMA; KIFQWAA; -.
DR Proteomes; UP000008068; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006631; P:fatty acid metabolic process; IEA:UniProtKB-KW.
DR CDD; cd17639; LC_FACS_euk1; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020459; AMP-binding.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43272:SF83; ACYL-COA SYNTHETASE LONG-CHAIN, ISOFORM J; 1.
DR PANTHER; PTHR43272; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR PRINTS; PR00154; AMPBINDING.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 3: Inferred from homology;
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008068};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 130..541
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 596..683
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 718 AA; 80144 MW; FB8D835D3D8472D6 CRC64;
MVDESDVKSA LNGHDRPFTI TLAIVLLKIV FFIYDIVTFI PFKIFADPAE KLEKSGRVKA
EPDNDDATTP WKNISAKDGL MNSSFEGIHD LGTQWEECVR RYGDLPCMGT REVLKVHKEK
QSNGKIFEKW QMGDYHWRSY AQVDKRVNMI ASGLTSLGQQ EKEPIILFAE TREEWMTTAL
ACMKMNFPIA TMYATLGDEA VQFAINEVGA KTIFTTEALI SKVKKAMSNG ATSIENIIFF
DSVDPASRGE SVDVDLPFTL LSFDQLLSRG EPHPVPIRSK KDDLAFIMYT SGTTGNPKGV
MISHQNIVAV TAGQAFNIVL GTEDRYIGYL PLAHILEVCA EMVVFTKGVR IGYSSAQTLF
DRAPKIMKGE HGDCWVLQPT LMACVPAVMD RIFKAVIDEV NANSELFKQL FKTCYERKRS
RYEEGYTSFI LNKLVFNRIG KLLGGKVRQI LSGGAPLSPE TQRFMNICFC CPVVQGYGLT
ETCGGGTIAD IHDLSTGTVG PPLTCCEILL QEWAEAGYSP KNDPPQGEIL ISGPNVALGY
FKNQEKTDEE FVKVNGKRFF ATGDIGEFRE DGSLKIIDRK KDLLKLAHGE YISLGKVETN
LLTNPNIDNV CVYGDSNKSF LVALVVPNQK NLTTLAEKQG VDTSNYEKMC EDKKVVEALQ
KELASYVSSK LQRVEIPQKI FICHEPWTPA SGLLTEALKL KRKNIEKAFR KELDELYK
//
