ID G0NGR7_CAEBE Unreviewed; 761 AA.
AC G0NGR7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 24-JAN-2024, entry version 54.
DE SubName: Full=CBN-MLH-1 protein {ECO:0000313|EMBL:EGT60154.1};
GN Name=Cbn-mlh-1 {ECO:0000313|EMBL:EGT60154.1};
GN ORFNames=CAEBREN_14366 {ECO:0000313|EMBL:EGT60154.1};
OS Caenorhabditis brenneri (Nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=135651 {ECO:0000313|Proteomes:UP000008068};
RN [1] {ECO:0000313|Proteomes:UP000008068}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB2801 {ECO:0000313|Proteomes:UP000008068};
RG Caenorhabditis brenneri Sequencing and Analysis Consortium;
RA Wilson R.K.;
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; GL379882; EGT60154.1; -; Genomic_DNA.
DR AlphaFoldDB; G0NGR7; -.
DR STRING; 135651.G0NGR7; -.
DR EnsemblMetazoa; CBN14366.1; CBN14366.1; WBGene00153091.
DR eggNOG; KOG1979; Eukaryota.
DR HOGENOM; CLU_004131_2_0_1; -.
DR InParanoid; G0NGR7; -.
DR OMA; ANYHVKK; -.
DR Proteomes; UP000008068; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR032189; Mlh1_C.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF16413; Mlh1_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008068}.
FT DOMAIN 210..337
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT REGION 384..404
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 430..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 442..457
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 761 AA; 86979 MW; 81E6991EE33B7ACB CRC64;
MGLIQRLPPD VVNRMAAGEV LARPCNAIKE LIENSLDAGA TEIMVNVQNA GLKLLQVTDN
GKGIEREDFD LVCERFATSK LHKFEDLMHM KTYGFRGEAL ASLSHVAKVN IVSKRAEDKC
AYQGNFLDGK LIAPTKPSAG KTGTCITATD LFYNLPTRRN KMATHGEETK AIHDILVRFA
IHRPDVSFAL RQNQSSDFRT KGDGSFRDVV CNLLGRDLAD TVVPLSLEST RLKFKFTGNI
SKPIASATAK LAQNRKSSRS FFSVFINGRS VRCDILKQPI DDVLQNRSLF CQFCSLHLEI
DETRIDVNVH PTKSSVIFLE KEDIIDEIRN YFENFVSEIF GFEPREAVKS EEDEEENNTN
SFSFSQIPII NIHTQSIKSI EGIRKSSSNS ELKPNSSFRN NEKKRVDYMD IRTDSKERKI
DEFVVRCPNA GLKRPRNDGE DEEIGDLEPV EEEDDVQKTA ELDDVSMVSL VSNTDGRAND
SQDLGEDADL ECGTTHREFD FESLDIIRRQ IVSTTSLSLR EMIKTSTFVG SIDCEQVLFQ
FGTSLYIMNF KAVLREFFYQ ISIFSFGNFG SYRLEQEPPS ILEMLELIGE LSENDERYKG
FGVFKQEEKR VEAENLLGEQ AELLHDYFAI KMEWFGEEED QRRLHLTEIP SLVHYYVPQL
EKLPFLIAAL ILDVDYDDEQ KCFESVSRAI GDLFTLHKHF VTDEKKVSRF STMYWKPLIK
QILMPLVKRK FIPPEHFKEK QIIKQLADSH DLYKVFERCG A
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