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Database: UniProt
Entry: G0P5L9_CAEBE
LinkDB: G0P5L9_CAEBE
Original site: G0P5L9_CAEBE 
ID   G0P5L9_CAEBE            Unreviewed;       872 AA.
AC   G0P5L9;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   07-JUN-2017, entry version 29.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=CAEBREN_11295 {ECO:0000313|EMBL:EGT51100.1}, CAEBREN_28108
GN   {ECO:0000313|EMBL:EGT45524.1};
OS   Caenorhabditis brenneri (Nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=135651 {ECO:0000313|Proteomes:UP000008068};
RN   [1] {ECO:0000313|EMBL:EGT45524.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=PB2801 {ECO:0000313|EMBL:EGT45524.1};
RG   The Caenorhabditis brenneri Sequencing and Analysis Consortium;
RA   Wilson R.K.;
RL   Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000008068}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PB2801 {ECO:0000313|Proteomes:UP000008068};
RG   Caenorhabditis brenneri Sequencing and Analysis Consortium;
RA   Wilson R.K.;
RL   Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:EGT45524.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PB2801 {ECO:0000313|EMBL:EGT45524.1};
RG   WormBase Consortium;
RL   Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; GL380085; EGT45524.1; -; Genomic_DNA.
DR   EMBL; GL380240; EGT51100.1; -; Genomic_DNA.
DR   STRING; 135651.CBN28108; -.
DR   EnsemblMetazoa; CBN11295; CBN11295; WBGene00150020.
DR   EnsemblMetazoa; CBN28108; CBN28108; WBGene00190073.
DR   eggNOG; KOG2189; Eukaryota.
DR   eggNOG; COG1269; LUCA.
DR   OMA; CYLSQWY; -.
DR   OrthoDB; EOG091G01BI; -.
DR   Proteomes; UP000008068; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000008068};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008068};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    402    426       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    447    465       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    544    562       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    574    597       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    668    687       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    786    806       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    812    836       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       51     78       {ECO:0000256|SAM:Coils}.
FT   COILED       96    123       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   872 AA;  99418 MW;  D3156608F0F7FBFE CRC64;
     MGSLSRSEEM RFCQLIVEKD AAFNIVAEIG KKPYVQFKDL NPNVNNFQRT FVKDIRRYDE
     MERKLRFLEN QIVRDEIVIP GKVDNGDYSI LPNSELNTLE GTLTELEKDV KSMNDSDAQL
     KANFLDLKEW DAVLDKTDEF FQGGVDDQAQ EELENLDEDG AIRTDKGPVN YLVGIIRRER
     LNGFERVLWR ACHHTAYIRS SDIEEELEDP SGEKVHKSVF IVFLKGDRMR SIVEKVCDGF
     KAKLFKNCPK TFKERQSARN DVRARIQDLQ TVLGQTREHR FRVLQAAANN HHQWLKQVRM
     IKTVFHMLNL FTFDGIGRFF VGECWIPLRH VDDVRKAIEI GAERSGSSVK PVLNILETSV
     TPPTYNATNK FTAVFQGIVD SYGIATYREL NPAPYTIITF PFLFSCMFGD LGHGVIMLMA
     GLWFVLREKN LQARNIKDEI FNMFFGGRYI ILLMGIFSIH AGIVYNDLFA KSFNVFGSGW
     KNPYNMSEID SWLEHTEHGK EMLVELAPEQ AYDHAGGPYS FGVDPIWNIA ENKLNFLNSM
     KMKLSVILGI TQMTFGVILS FFNHTYNKSK IDIFTVFIPQ MLFMGCIFMY LCLQIILKWL
     FFWTKEATIF GQIYPGSHCA PSLLIGLINM FMMKDRNPGF VQDGGKVNGE YREVEACYLS
     QWYPGQSVIE MILVVIAVIC IPIMLFGKPI HHVMQQKKKQ KELHGNVTVR ANVVSDSSEI
     VINGGSKKEE AAHGGDHGGH DDESFGDVMV HQAIHTIEYV LGCVSHTASY LRLWALSLAH
     AQLSEVLWHM VFVTGGLGIS GTAGFIAVYV VFFIFFVLTI SILVLMEGLS AFLHTLRLHW
     VEFQSKFYLG LGYPFVPYSF KTSLQEAEAM AQ
//
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