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Database: UniProt
Entry: G0P6X0_CAEBE
LinkDB: G0P6X0_CAEBE
Original site: G0P6X0_CAEBE 
ID   G0P6X0_CAEBE            Unreviewed;      2865 AA.
AC   G0P6X0;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   24-JAN-2024, entry version 55.
DE   RecName: Full=Inositol 1,4,5-trisphosphate receptor {ECO:0000256|RuleBase:RU368044};
GN   ORFNames=CAEBREN_30230 {ECO:0000313|EMBL:EGT46599.1};
OS   Caenorhabditis brenneri (Nematode worm).
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=135651 {ECO:0000313|Proteomes:UP000008068};
RN   [1] {ECO:0000313|Proteomes:UP000008068}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PB2801 {ECO:0000313|Proteomes:UP000008068};
RG   Caenorhabditis brenneri Sequencing and Analysis Consortium;
RA   Wilson R.K.;
RL   Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Receptor for inositol 1,4,5-trisphosphate, a second messenger
CC       that mediates the release of intracellular calcium.
CC       {ECO:0000256|RuleBase:RU368044}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC       {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU368044}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC       ECO:0000256|RuleBase:RU368044}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- DOMAIN: The receptor contains a calcium channel in its C-terminal
CC       extremity. Its large N-terminal cytoplasmic region has the ligand-
CC       binding site in the N-terminus and modulatory sites in the middle
CC       portion immediately upstream of the channel region.
CC       {ECO:0000256|RuleBase:RU368044}.
CC   -!- SIMILARITY: Belongs to the InsP3 receptor family.
CC       {ECO:0000256|ARBA:ARBA00009453, ECO:0000256|RuleBase:RU368044}.
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DR   EMBL; GL380104; EGT46599.1; -; Genomic_DNA.
DR   STRING; 135651.G0P6X0; -.
DR   EnsemblMetazoa; CBN30230.1; CBN30230.1; WBGene00192195.
DR   eggNOG; KOG3533; Eukaryota.
DR   HOGENOM; CLU_000206_1_0_1; -.
DR   InParanoid; G0P6X0; -.
DR   Proteomes; UP000008068; Unassembled WGS sequence.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 2.80.10.50; -; 2.
DR   Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_IP3_receptor.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715:SF99; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; 1.
DR   PANTHER; PTHR13715; RYANODINE RECEPTOR AND IP3 RECEPTOR; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 3.
DR   SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 2.
DR   SUPFAM; SSF82109; MIR domain; 2.
DR   PROSITE; PS50919; MIR; 2.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU368044};
KW   Calcium channel {ECO:0000256|RuleBase:RU368044};
KW   Calcium transport {ECO:0000256|RuleBase:RU368044};
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW   ECO:0000256|RuleBase:RU368044};
KW   Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU368044};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU368044};
KW   Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW   ECO:0000256|RuleBase:RU368044};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU368044};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU368044};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008068};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU368044};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU368044};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU368044}.
FT   TRANSMEM        2424..2442
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU368044"
FT   TRANSMEM        2454..2470
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU368044"
FT   TRANSMEM        2482..2505
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU368044"
FT   TRANSMEM        2540..2568
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU368044"
FT   TRANSMEM        2589..2611
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU368044"
FT   TRANSMEM        2707..2729
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU368044"
FT   DOMAIN          146..200
FT                   /note="MIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50919"
FT   DOMAIN          273..333
FT                   /note="MIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50919"
FT   REGION          982..1009
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2627..2659
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        982..1003
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2865 AA;  327697 MW;  C43E17B2870FAB68 CRC64;
     MDYDYRRRVL ERNIGMALPS RKLTIASSID HGNNGNLHIG DIISLYTESS TNQEQRGFLS
     TLGLVDDRCI VELKDGRPES PPKKFRDCLF KVCPVNRYAA QKHLWTEQKR FQTGDSMFDD
     DLMNKLRVAA DKEREENEAE FQKTLGNVIQ YGSMIQLLHV KSNKYITVQK NSPAKRERNA
     MKVYLDRAGN EGSWFIIEPA YKHYAIGDNV SAGNKISLIP NSVSTTQTGH VKSQLHLSGF
     NLLDHQTAAE VNCLNEPTEW QVFMFLLFDE NQQNSVKSGD VVRLFHADQQ TFLTLDTIPK
     TNPAKDVVFL RMTNRPSAAD ATSSRALWEV QVVQTNAYRG GTAKWNKTYR FKHLASDMYL
     TVEASQVQVK PAVNGRPPLL SALSQKSRPM LERTNNPMAS MYSDGPNGVL NDSPDGPNVY
     FLSPTKSDFP ESNENLLFQL DPSTFMKSNK DVPRRSYVRL LHQSTDTWVH ATNATEKQNL
     HFSNKNEKGW VKVICETNRV DKETFALLPV NPDEVRDLDF ANDACKALRN FINLIKIGSV
     ISKEALNSTT QLLIDCILFV TNSSDHLADP LKITDFSPSR DRQKLLREQE VLHQVFLLLK
     APFQPRQGTT ELGALLSSPA ELSDSRNEIF KTMFQLCYCL LKYSQVSYRK NQEFLAEKFG
     EIQEQIGFDL MAEDTMTAVL HNNPKLLEKY KKEVHPKQEL IYRFLDYLAD LCVCRGEANK
     KIQELICTSV LSSTHRDIFM DTKIIDGEVE IGWAPNFRKL VDIAEGAKSN HDDVEHLDYY
     RHQLDLLSQM CQEQQYLAID PPPERGLMNI SQQLPAELVL QCMSDTRLPY DLRGSFTRLM
     LHLHVVRGSP MSAIRHARLW WSIPENVNVA TYESVSVEAY SDGSRMRIGA SIAHKVLATV
     ETYLMALRNQ STDERHSVNS SKLTYEIVNL AKALAQFNFY SFNELLQLTQ NLLAIINEGP
     TTEQVPSHRA MVNAIRNMSK SMMRGGSNKE NSKDIPKTSS MSTEDAGRSK EGRALIVKTK
     LIVAEILQFV MDVRRDYRIT MALSWFKNVF PCDEDGSLMH SASINERMAS ELYDAIYHSS
     GHELHLDGRD GQLLLAILLQ MTMSDYPPLT SIALKVLFRH FTQYQELLED LKQVQLLVSN
     DDVENYRQID RDLFILKNLT EKSELWVHGD RNHSVETKEV DDKEKTTEHD LQMHDLNSPR
     AFGSRDSMDA VIAVINEHYS NFKNESLQLL NRLLINDDRN DAAVALQELS DKAPLIAYPL
     IRQMLVRLTR MCYRDGKPDT MNQQLLKNMR VYEVVLEFIS VPHDKKHDHE MMKLITLSHE
     FLRSFCKANK ENQSRLYKFI SYEKDAKEGM LRVETVEEVG TLVAIFRNNR ELASNVPEEL
     IAHIVGLIEH NSRNPIFLEL LQALVCVYDK EIESGQEKVA NEICAASDEV RQLYVDNASF
     EELEALMKQE KESKGRETES RKPLKYHIEL VRLLAMCTRG KNGNTELKCA SQIPMDHIVR
     VVTSKHCLVE VKTVYLQLLL HCYIDTDAEM KDAYKTEYVD NILNNLLDDI RSLRVEKLTD
     AETVTLEHYI CHTVTEVLIK FFEAPYSALQ QAKVDVHHHK KTFSEVLLEL TSLERGKLKS
     TRSSRNWYRV AECIKRLTKW AEEHSITLPA TLAGPQMSGQ ASVRQKWQNA ATSAKLIGLN
     KRLNRQNTLN PGHRLYGTSN SMTEHTSANV VTCYHMMIGE FKFYLHPLHA AEGSVLVEVL
     HTPELLFPEG SLLRDQCARG GVVAKLIQHC KTLMQNKQDN LCARVLQTLC KMCDCTKQQL
     TQQGRRIYIS SFEKGQQLRH LLLQRYFGQH NHHHPPLDRQ QSKIGEVIEA VKEKKEETWS
     QERDLYAIQC KLNDAGASDL VIDIIIMEPS REIFLKAIHL ARALLHEGND KVSRTGRRYV
     IQFIILFQVQ HSFYMRMKQK DIHEPFFKVI LTRIQTAQNR LKSDMMSCSD SKPKASSTVL
     TPLIDAGDSG FNGTLFEVPQ QVRHPSISEM SQLSNDLTHS IPDLTPYQDE DKSTDALPPE
     VALVEPILRV LQLLCENHNS LLQNFLRKQS DRTNHNLVSE TLSFLDTVCG STKGSLGVFG
     EIGEHNFSLI TQTLATLTEF CQGPCHENQN TMAMQENGLN IIISLVLNEI KPLADDHMEL
     ALEIKSQASK LLLAIMESRH DGENANRVLR NMANMSGGPK QLVHAIKQAY EMTNSNHHML
     KSVSRDLFRR AEDDSKTKSG PQITVNTVTL PEINVDASGI VSIHTEKNIS SSLDDKFHED
     DSPSVDPREV GHNIYILAHQ LAIHDGELEI WLDGSDEKKD DLTREALNYY KERTAQIESN
     LQIVRRDRTL ERVVFPINDI CSFLTKETKD YVYNNTERDN QGSKVTEFFD QWESMYHEMI
     WQRKLQDRKW LSWCAFRLPL WTRLSFHFAF IVNAIVACYY PFPESNAPIS FGNLYNWIAV
     ITSFLLAHYL RHDKSYLPKT FLLILASLCF LLVSSIGVNL TLHFFGILQL VNKVVHVLAF
     VSNKGLEDRP LSEILACRNL LYLLVYLAVC IAGLLVHPMI YCALLFDIIA TEETLQNVIA
     SVTRNYQSIV WTGLLALILL YIFSILGFLF FRQDFYLEVD PVESDSPASI SSGMPSDTCP
     SEGCPGLKPT AKNDDDDDKK VKSCETLWMC ILQTMYLGLR NGGGIGDVLR NPAPWEDTFK
     WRVAYDMTFF VVLIVIVLNL IFGVIIDTFG DLRAEKNEKE QILKNNCFIC GLDRSRFDNR
     SVTFETHRET EHNIWHYLFY IVMLQIKDET EFTGPESYVA QCVKDRNLDW FPRMQALSLQ
     DSELDSDQSE MKQMKDLVLQ ILAMQREGQS QMDEVRAFME QFQSR
//
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