ID G0P6X0_CAEBE Unreviewed; 2865 AA.
AC G0P6X0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 24-JAN-2024, entry version 55.
DE RecName: Full=Inositol 1,4,5-trisphosphate receptor {ECO:0000256|RuleBase:RU368044};
GN ORFNames=CAEBREN_30230 {ECO:0000313|EMBL:EGT46599.1};
OS Caenorhabditis brenneri (Nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=135651 {ECO:0000313|Proteomes:UP000008068};
RN [1] {ECO:0000313|Proteomes:UP000008068}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB2801 {ECO:0000313|Proteomes:UP000008068};
RG Caenorhabditis brenneri Sequencing and Analysis Consortium;
RA Wilson R.K.;
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for inositol 1,4,5-trisphosphate, a second messenger
CC that mediates the release of intracellular calcium.
CC {ECO:0000256|RuleBase:RU368044}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU368044}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC ECO:0000256|RuleBase:RU368044}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- DOMAIN: The receptor contains a calcium channel in its C-terminal
CC extremity. Its large N-terminal cytoplasmic region has the ligand-
CC binding site in the N-terminus and modulatory sites in the middle
CC portion immediately upstream of the channel region.
CC {ECO:0000256|RuleBase:RU368044}.
CC -!- SIMILARITY: Belongs to the InsP3 receptor family.
CC {ECO:0000256|ARBA:ARBA00009453, ECO:0000256|RuleBase:RU368044}.
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DR EMBL; GL380104; EGT46599.1; -; Genomic_DNA.
DR STRING; 135651.G0P6X0; -.
DR EnsemblMetazoa; CBN30230.1; CBN30230.1; WBGene00192195.
DR eggNOG; KOG3533; Eukaryota.
DR HOGENOM; CLU_000206_1_0_1; -.
DR InParanoid; G0P6X0; -.
DR Proteomes; UP000008068; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR000493; InsP3_rcpt.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR PANTHER; PTHR13715:SF99; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; 1.
DR PANTHER; PTHR13715; RYANODINE RECEPTOR AND IP3 RECEPTOR; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR PRINTS; PR00779; INSP3RECEPTR.
DR SMART; SM00472; MIR; 3.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 2.
DR SUPFAM; SSF82109; MIR domain; 2.
DR PROSITE; PS50919; MIR; 2.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|RuleBase:RU368044};
KW Calcium channel {ECO:0000256|RuleBase:RU368044};
KW Calcium transport {ECO:0000256|RuleBase:RU368044};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|RuleBase:RU368044};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU368044};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU368044};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU368044};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU368044};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU368044};
KW Reference proteome {ECO:0000313|Proteomes:UP000008068};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU368044};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU368044};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU368044}.
FT TRANSMEM 2424..2442
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2454..2470
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2482..2505
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2540..2568
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2589..2611
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2707..2729
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT DOMAIN 146..200
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 273..333
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT REGION 982..1009
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2627..2659
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 982..1003
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2865 AA; 327697 MW; C43E17B2870FAB68 CRC64;
MDYDYRRRVL ERNIGMALPS RKLTIASSID HGNNGNLHIG DIISLYTESS TNQEQRGFLS
TLGLVDDRCI VELKDGRPES PPKKFRDCLF KVCPVNRYAA QKHLWTEQKR FQTGDSMFDD
DLMNKLRVAA DKEREENEAE FQKTLGNVIQ YGSMIQLLHV KSNKYITVQK NSPAKRERNA
MKVYLDRAGN EGSWFIIEPA YKHYAIGDNV SAGNKISLIP NSVSTTQTGH VKSQLHLSGF
NLLDHQTAAE VNCLNEPTEW QVFMFLLFDE NQQNSVKSGD VVRLFHADQQ TFLTLDTIPK
TNPAKDVVFL RMTNRPSAAD ATSSRALWEV QVVQTNAYRG GTAKWNKTYR FKHLASDMYL
TVEASQVQVK PAVNGRPPLL SALSQKSRPM LERTNNPMAS MYSDGPNGVL NDSPDGPNVY
FLSPTKSDFP ESNENLLFQL DPSTFMKSNK DVPRRSYVRL LHQSTDTWVH ATNATEKQNL
HFSNKNEKGW VKVICETNRV DKETFALLPV NPDEVRDLDF ANDACKALRN FINLIKIGSV
ISKEALNSTT QLLIDCILFV TNSSDHLADP LKITDFSPSR DRQKLLREQE VLHQVFLLLK
APFQPRQGTT ELGALLSSPA ELSDSRNEIF KTMFQLCYCL LKYSQVSYRK NQEFLAEKFG
EIQEQIGFDL MAEDTMTAVL HNNPKLLEKY KKEVHPKQEL IYRFLDYLAD LCVCRGEANK
KIQELICTSV LSSTHRDIFM DTKIIDGEVE IGWAPNFRKL VDIAEGAKSN HDDVEHLDYY
RHQLDLLSQM CQEQQYLAID PPPERGLMNI SQQLPAELVL QCMSDTRLPY DLRGSFTRLM
LHLHVVRGSP MSAIRHARLW WSIPENVNVA TYESVSVEAY SDGSRMRIGA SIAHKVLATV
ETYLMALRNQ STDERHSVNS SKLTYEIVNL AKALAQFNFY SFNELLQLTQ NLLAIINEGP
TTEQVPSHRA MVNAIRNMSK SMMRGGSNKE NSKDIPKTSS MSTEDAGRSK EGRALIVKTK
LIVAEILQFV MDVRRDYRIT MALSWFKNVF PCDEDGSLMH SASINERMAS ELYDAIYHSS
GHELHLDGRD GQLLLAILLQ MTMSDYPPLT SIALKVLFRH FTQYQELLED LKQVQLLVSN
DDVENYRQID RDLFILKNLT EKSELWVHGD RNHSVETKEV DDKEKTTEHD LQMHDLNSPR
AFGSRDSMDA VIAVINEHYS NFKNESLQLL NRLLINDDRN DAAVALQELS DKAPLIAYPL
IRQMLVRLTR MCYRDGKPDT MNQQLLKNMR VYEVVLEFIS VPHDKKHDHE MMKLITLSHE
FLRSFCKANK ENQSRLYKFI SYEKDAKEGM LRVETVEEVG TLVAIFRNNR ELASNVPEEL
IAHIVGLIEH NSRNPIFLEL LQALVCVYDK EIESGQEKVA NEICAASDEV RQLYVDNASF
EELEALMKQE KESKGRETES RKPLKYHIEL VRLLAMCTRG KNGNTELKCA SQIPMDHIVR
VVTSKHCLVE VKTVYLQLLL HCYIDTDAEM KDAYKTEYVD NILNNLLDDI RSLRVEKLTD
AETVTLEHYI CHTVTEVLIK FFEAPYSALQ QAKVDVHHHK KTFSEVLLEL TSLERGKLKS
TRSSRNWYRV AECIKRLTKW AEEHSITLPA TLAGPQMSGQ ASVRQKWQNA ATSAKLIGLN
KRLNRQNTLN PGHRLYGTSN SMTEHTSANV VTCYHMMIGE FKFYLHPLHA AEGSVLVEVL
HTPELLFPEG SLLRDQCARG GVVAKLIQHC KTLMQNKQDN LCARVLQTLC KMCDCTKQQL
TQQGRRIYIS SFEKGQQLRH LLLQRYFGQH NHHHPPLDRQ QSKIGEVIEA VKEKKEETWS
QERDLYAIQC KLNDAGASDL VIDIIIMEPS REIFLKAIHL ARALLHEGND KVSRTGRRYV
IQFIILFQVQ HSFYMRMKQK DIHEPFFKVI LTRIQTAQNR LKSDMMSCSD SKPKASSTVL
TPLIDAGDSG FNGTLFEVPQ QVRHPSISEM SQLSNDLTHS IPDLTPYQDE DKSTDALPPE
VALVEPILRV LQLLCENHNS LLQNFLRKQS DRTNHNLVSE TLSFLDTVCG STKGSLGVFG
EIGEHNFSLI TQTLATLTEF CQGPCHENQN TMAMQENGLN IIISLVLNEI KPLADDHMEL
ALEIKSQASK LLLAIMESRH DGENANRVLR NMANMSGGPK QLVHAIKQAY EMTNSNHHML
KSVSRDLFRR AEDDSKTKSG PQITVNTVTL PEINVDASGI VSIHTEKNIS SSLDDKFHED
DSPSVDPREV GHNIYILAHQ LAIHDGELEI WLDGSDEKKD DLTREALNYY KERTAQIESN
LQIVRRDRTL ERVVFPINDI CSFLTKETKD YVYNNTERDN QGSKVTEFFD QWESMYHEMI
WQRKLQDRKW LSWCAFRLPL WTRLSFHFAF IVNAIVACYY PFPESNAPIS FGNLYNWIAV
ITSFLLAHYL RHDKSYLPKT FLLILASLCF LLVSSIGVNL TLHFFGILQL VNKVVHVLAF
VSNKGLEDRP LSEILACRNL LYLLVYLAVC IAGLLVHPMI YCALLFDIIA TEETLQNVIA
SVTRNYQSIV WTGLLALILL YIFSILGFLF FRQDFYLEVD PVESDSPASI SSGMPSDTCP
SEGCPGLKPT AKNDDDDDKK VKSCETLWMC ILQTMYLGLR NGGGIGDVLR NPAPWEDTFK
WRVAYDMTFF VVLIVIVLNL IFGVIIDTFG DLRAEKNEKE QILKNNCFIC GLDRSRFDNR
SVTFETHRET EHNIWHYLFY IVMLQIKDET EFTGPESYVA QCVKDRNLDW FPRMQALSLQ
DSELDSDQSE MKQMKDLVLQ ILAMQREGQS QMDEVRAFME QFQSR
//