ID G0PF26_CAEBE Unreviewed; 902 AA.
AC G0PF26;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 24-JAN-2024, entry version 57.
DE RecName: Full=Ubiquitin carboxyl-terminal hydrolase {ECO:0000256|RuleBase:RU366025};
DE EC=3.4.19.12 {ECO:0000256|RuleBase:RU366025};
GN ORFNames=CAEBREN_19011 {ECO:0000313|EMBL:EGT53487.1};
OS Caenorhabditis brenneri (Nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=135651 {ECO:0000313|Proteomes:UP000008068};
RN [1] {ECO:0000313|Proteomes:UP000008068}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB2801 {ECO:0000313|Proteomes:UP000008068};
RG Caenorhabditis brenneri Sequencing and Analysis Consortium;
RA Wilson R.K.;
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Thiol-dependent hydrolysis of ester, thioester, amide, peptide
CC and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-
CC residue protein attached to proteins as an intracellular targeting
CC signal).; EC=3.4.19.12; Evidence={ECO:0000256|RuleBase:RU366025};
CC -!- SIMILARITY: Belongs to the peptidase C19 family.
CC {ECO:0000256|RuleBase:RU366025}.
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DR EMBL; GL380341; EGT53487.1; -; Genomic_DNA.
DR AlphaFoldDB; G0PF26; -.
DR STRING; 135651.G0PF26; -.
DR MEROPS; C19.A33; -.
DR EnsemblMetazoa; CBN19011.1; CBN19011.1; WBGene00157736.
DR eggNOG; KOG1870; Eukaryota.
DR HOGENOM; CLU_001060_8_2_1; -.
DR InParanoid; G0PF26; -.
DR OMA; PCHAQQS; -.
DR Proteomes; UP000008068; Unassembled WGS sequence.
DR GO; GO:0004843; F:cysteine-type deubiquitinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 2.
DR Gene3D; 3.30.2230.10; DUSP-like; 1.
DR InterPro; IPR035927; DUSP-like_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR006615; Pept_C19_DUSP.
DR InterPro; IPR001394; Peptidase_C19_UCH.
DR InterPro; IPR018200; USP_CS.
DR InterPro; IPR028889; USP_dom.
DR PANTHER; PTHR21646; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR PANTHER; PTHR21646:SF24; UBIQUITIN CARBOXYL-TERMINAL HYDROLASE; 1.
DR Pfam; PF06337; DUSP; 1.
DR Pfam; PF00443; UCH; 1.
DR SMART; SM00695; DUSP; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF143791; DUSP-like; 1.
DR PROSITE; PS51283; DUSP; 1.
DR PROSITE; PS00972; USP_1; 1.
DR PROSITE; PS00973; USP_2; 1.
DR PROSITE; PS50235; USP_3; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|RuleBase:RU366025};
KW Protease {ECO:0000256|RuleBase:RU366025};
KW Reference proteome {ECO:0000313|Proteomes:UP000008068};
KW Thiol protease {ECO:0000256|RuleBase:RU366025};
KW Ubl conjugation pathway {ECO:0000256|RuleBase:RU366025}.
FT DOMAIN 23..131
FT /note="DUSP"
FT /evidence="ECO:0000259|PROSITE:PS51283"
FT DOMAIN 281..849
FT /note="USP"
FT /evidence="ECO:0000259|PROSITE:PS50235"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 239..261
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 854..902
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..30
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 872..890
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 902 AA; 102630 MW; 0D8DCB3FCC3409E4 CRC64;
MPTPDDVSME EADVKGAEGS DEESNNPTRD ELRRLLTEVE QTEMLENESW FLISQKWWNS
LLKAVRDGFV DDLPPIDNSN ISECRQGSFF LKQRLAEQVD YTPVPSKVFK RLETFYQVED
PRRDYITRQV VPKNGSLCLE VYPRIVHVAL ARNRDMKADV TLKSDDTMAS LRERVITELN
LEANQNVRFY VMSSDNPELI DTTQSIDSYF DTVQKVLVDV EENGEFFFRG KNAVQPQSKT
LYGNQASSSS SSSLGGHSVS NSYNTASPTH GVVTRTTPGA CGLSNLGNTC FMASAFQCLS
NIPPLRDYFI NEEYLQDLNE ENPLGTHGNL AVAVGDLMKG MWSGEYASIN PRKFKGIIGQ
FAPRFNGYSQ QDAHELMAYV LDGLHEDLNR IKKKPYIEDN DEDAKLPEAE YAAKSWQVYK
MRNDSIIVDT LHGQLRSTLI CPVCQKISIK FDPFGYLSLP LPPKEQIVKQ TVIVMFLNRK
WAKFSLGITD TTTVEEAESL MLEKLQLEEP HHFVFFHVPS AYHDDIAILQ PGDRVRMQGR
EVYVAQVEHD LSVKGTRIFV AYNRVKIVKP ASLPMIYSLA PGFPLTRGFL NDHVFNTTKR
LFINQKIATE LNGNDDDSMS GNSSDEREPY KLFVGDPGSQ TPLPISSTND PIPFPDEMSN
DLYRNYLQVI FQWKDIKLFN QYKGADLVER EMTVATRRRV LLEETLNWFT KKEQLGEQDS
WYCPQCKKHE RASKQLDLWK LPEILILHLK RFQYTKWSRE KLTWDVVIPV RGLDLTAKVA
NPNHEAAVYD LIAVSRHYGS LSGGHYTAIG FNDKAQKWFD FNDSSSNVSS PPNEPYESSD
PYILVYRRRK LDDKGVPIEP AAPVESNNRH KRGAAPSISS ATTSNGSSSR HHLDENMEME
ED
//