ID G0PLB9_CAEBE Unreviewed; 811 AA.
AC G0PLB9;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
GN ORFNames=CAEBREN_00313 {ECO:0000313|EMBL:EGT34482.1};
OS Caenorhabditis brenneri (Nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=135651 {ECO:0000313|Proteomes:UP000008068};
RN [1] {ECO:0000313|Proteomes:UP000008068}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PB2801 {ECO:0000313|Proteomes:UP000008068};
RG Caenorhabditis brenneri Sequencing and Analysis Consortium;
RA Wilson R.K.;
RL Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC repulsion of neuronal growth cones in the developing nervous system
CC upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367033};
CC Single-pass type I membrane protein {ECO:0000256|RuleBase:RU367033}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the unc-5 family.
CC {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
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DR EMBL; GL381054; EGT34482.1; -; Genomic_DNA.
DR AlphaFoldDB; G0PLB9; -.
DR STRING; 135651.G0PLB9; -.
DR EnsemblMetazoa; CBN00313.1; CBN00313.1; WBGene00139038.
DR eggNOG; KOG1480; Eukaryota.
DR HOGENOM; CLU_014383_0_0_1; -.
DR InParanoid; G0PLB9; -.
DR OMA; AMNCLEL; -.
DR Proteomes; UP000008068; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IEA:UniProtKB-UniRule.
DR CDD; cd08781; Death_UNC5-like; 1.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR033772; UPA.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582:SF47; NETRIN RECEPTOR UNC-5; 1.
DR PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF13895; Ig_2; 1.
DR Pfam; PF00090; TSP_1; 2.
DR Pfam; PF17217; UPA; 1.
DR Pfam; PF00791; ZU5; 1.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 2.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 1.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 2.
DR PROSITE; PS51145; ZU5; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU367033};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW ECO:0000256|RuleBase:RU367033};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367033};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW Reference proteome {ECO:0000313|Proteomes:UP000008068};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367033};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367033}.
FT TRANSMEM 231..254
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT DOMAIN 3..90
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 394..522
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 721..802
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 346..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 811 AA; 89726 MW; E0181A267DB6F01F CRC64;
MRKHFLKSPV AQRVQEGTTL QLPCQSPESD PKAELTWYKD GVVVQPDANV IRASDGSLIM
SAARLSDSGN YTCEATNVAN SRRTDPVEVQ IYVDGGWSEW SPWIGTCHVD CPLLRQHAHR
IRDPHDVLPH QRRTRTCNNP APLNGGEYCK GEEEMTRHCK VPCKLDGGWS SWSEWSACSS
SCHRYRTRAC TVPPPMNGGQ PCFGDDLMTQ ECPAQLCTAD SSRIVISDTA VYGSVASIFI
VASFILAIIA MFCCKRNGKK TKSTKPLKMI PEKSGGIYYS EPPGVRRLLL EHQHGTLLGE
KISSCSQYFE PPPLPHSTTL RSGKSAFSGY SSTRNAGSRA ALIQECSSSS SGSGGGKRTI
LRTSSSNCSD DDNYATLYDY MEDKSVLGLD TSQNIVAAQI DGNGARLSLA KSGARLIVPE
LAVEGEKMLY LAVSDTLSDQ PHLPPIESAL SPVIVIGQCD VSSSSPDNIL RRPVVVSFRH
CASTFPRDNW QFTLYADEGN GWQKSVTIGE ENLNTNMFVQ FEQPGKKNDG FGWCHVMTYS
LARLMLAGHP RRNSLSAAKR VHLAVFGPPE MSAYRRAFEL RVYCVPETGA AMESVWKQED
GSRLLCESND FILNEKGNLC ICIEDVAPGF SCEGPEVVEI SETQHRWVAQ NGLHCSLKFR
PKDTVSPQFS TRVIVYQKSS SMEPMIMEVN NEPDLYDATS EEREKGSVCV EFRLPFDVKD
QLARLLDPPN DINSDWRTLA KKLHYDRYLQ FFASFPDCSP TSLLLDLWEA SSSGSARAVP
DLLQTLRVMG RPDAVMVLER FLSAFPQIVS P
//
