ID G0RAY5_HYPJQ Unreviewed; 739 AA.
AC G0RAY5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 24-JAN-2024, entry version 61.
DE SubName: Full=DNA mismatch repair protein {ECO:0000313|EMBL:EGR51936.1};
GN ORFNames=TRIREDRAFT_21460 {ECO:0000313|EMBL:EGR51936.1};
OS Hypocrea jecorina (strain QM6a) (Trichoderma reesei).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=431241 {ECO:0000313|Proteomes:UP000008984};
RN [1] {ECO:0000313|EMBL:EGR51936.1, ECO:0000313|Proteomes:UP000008984}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=QM6a {ECO:0000313|EMBL:EGR51936.1,
RC ECO:0000313|Proteomes:UP000008984};
RX PubMed=18454138; DOI=10.1038/nbt1403;
RA Martinez D., Berka R.M., Henrissat B., Saloheimo M., Arvas M., Baker S.E.,
RA Chapman J., Chertkov O., Coutinho P.M., Cullen D., Danchin E.G.,
RA Grigoriev I.V., Harris P., Jackson M., Kubicek C.P., Han C.S., Ho I.,
RA Larrondo L.F., de Leon A.L., Magnuson J.K., Merino S., Misra M., Nelson B.,
RA Putnam N., Robbertse B., Salamov A.A., Schmoll M., Terry A., Thayer N.,
RA Westerholm-Parvinen A., Schoch C.L., Yao J., Barabote R., Nelson M.A.,
RA Detter C., Bruce D., Kuske C.R., Xie G., Richardson P., Rokhsar D.S.,
RA Lucas S.M., Rubin E.M., Dunn-Coleman N., Ward M., Brettin T.S.;
RT "Genome sequencing and analysis of the biomass-degrading fungus Trichoderma
RT reesei (syn. Hypocrea jecorina).";
RL Nat. Biotechnol. 26:553-560(2008).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082}.
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DR EMBL; GL985057; EGR51936.1; -; Genomic_DNA.
DR RefSeq; XP_006961980.1; XM_006961918.1.
DR AlphaFoldDB; G0RAY5; -.
DR STRING; 431241.G0RAY5; -.
DR EnsemblFungi; EGR51936; EGR51936; TRIREDRAFT_21460.
DR GeneID; 18483992; -.
DR KEGG; tre:TRIREDRAFT_21460; -.
DR VEuPathDB; FungiDB:TRIREDRAFT_21460; -.
DR eggNOG; KOG1979; Eukaryota.
DR HOGENOM; CLU_004131_2_0_1; -.
DR OrthoDB; 5475669at2759; -.
DR Proteomes; UP000008984; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0061982; P:meiosis I cell cycle process; IEA:UniProt.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd03483; MutL_Trans_MLH1; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR032189; Mlh1_C.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF16413; Mlh1_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000008984}.
FT DOMAIN 245..364
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 661..685
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 739 AA; 82248 MW; E873F2D3B9F1994E CRC64;
MDGMDIDSAP SGTKRKAVDE IESPKPARRI RALDPDVVNK IAAGEIIVAP VHALKELIEN
AVDAGSTSLE ILVKDGGLKL LQITDNGGGI EKDDLEILCV RHTTSKISTF EDLSSIATYG
FRGEALASIS HIAHLTVTTK TKESSVAWRA HYLDGKLAPA KPGQSAEPKA VAGRQGTQIT
VEDLFFNVPT RRRAFRSYAD EFNKIIDMAG RYAIHCRGVG FTCKKAGEAT NTLSIQAQAT
VIDRIRQIHG SNVANELIEI SASDDRWGFS AHGYVTNANY HIKKTTLLLF INHRCVESTS
MKKALEQTYS SFLPKGGHPF IYLSLEIDPA RVDVNVHPTK REVHFLNEEE ILQVICQSIE
TELAKVDASR TFMTQTLLPG AKPVEPLDED DSDAAYKFTT PALRKVRRNS NDLVRTDTSQ
GKITAMFAPA GPSKPAGSPA KGTIEDEAWA VPEPVEYTTI DRDQVQCRLG SVKQLRQEVR
DEIHHELTEI IASHTFVGIV DEERRLAAIQ GGVKLYLIDY GHACFEYFYQ LGLTDFGNFG
TINFNPPLDL RELLQLGAEG EKEAMGVSGE ELDVDVIVEK VANQLIERRE MLLEYFSLEI
TPTGELISIP LLVKGYTPSI GKLPRFLIRL GPHVDWNDEK SCFHTFLTEL ATFYVPEPLP
TSPSGKFEEE EGSLKDEQKE EEEEALEELR ARRQHVRWAV EHIFFPTFKS RLVATKKLME
GAVLEVASLK GLYRVFERC
//
