ID G0RJC0_HYPJQ Unreviewed; 620 AA.
AC G0RJC0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 24-JAN-2024, entry version 56.
DE RecName: Full=Polyadenylation factor subunit 2 {ECO:0000256|ARBA:ARBA00026154, ECO:0000256|RuleBase:RU369034};
GN ORFNames=TRIREDRAFT_22287 {ECO:0000313|EMBL:EGR48730.1};
OS Hypocrea jecorina (strain QM6a) (Trichoderma reesei).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=431241 {ECO:0000313|Proteomes:UP000008984};
RN [1] {ECO:0000313|EMBL:EGR48730.1, ECO:0000313|Proteomes:UP000008984}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=QM6a {ECO:0000313|EMBL:EGR48730.1,
RC ECO:0000313|Proteomes:UP000008984};
RX PubMed=18454138; DOI=10.1038/nbt1403;
RA Martinez D., Berka R.M., Henrissat B., Saloheimo M., Arvas M., Baker S.E.,
RA Chapman J., Chertkov O., Coutinho P.M., Cullen D., Danchin E.G.,
RA Grigoriev I.V., Harris P., Jackson M., Kubicek C.P., Han C.S., Ho I.,
RA Larrondo L.F., de Leon A.L., Magnuson J.K., Merino S., Misra M., Nelson B.,
RA Putnam N., Robbertse B., Salamov A.A., Schmoll M., Terry A., Thayer N.,
RA Westerholm-Parvinen A., Schoch C.L., Yao J., Barabote R., Nelson M.A.,
RA Detter C., Bruce D., Kuske C.R., Xie G., Richardson P., Rokhsar D.S.,
RA Lucas S.M., Rubin E.M., Dunn-Coleman N., Ward M., Brettin T.S.;
RT "Genome sequencing and analysis of the biomass-degrading fungus Trichoderma
RT reesei (syn. Hypocrea jecorina).";
RL Nat. Biotechnol. 26:553-560(2008).
CC -!- FUNCTION: Required for 3'-end cleavage and polyadenylation of pre-
CC mRNAs. Also involved in chromosome segregation where it has a role in
CC chromosome attachment to the mitotic spindle.
CC {ECO:0000256|ARBA:ARBA00025498}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU369034}.
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DR EMBL; GL985064; EGR48730.1; -; Genomic_DNA.
DR RefSeq; XP_006965228.1; XM_006965166.1.
DR AlphaFoldDB; G0RJC0; -.
DR STRING; 431241.G0RJC0; -.
DR EnsemblFungi; EGR48730; EGR48730; TRIREDRAFT_22287.
DR GeneID; 18484109; -.
DR KEGG; tre:TRIREDRAFT_22287; -.
DR VEuPathDB; FungiDB:TRIREDRAFT_22287; -.
DR eggNOG; KOG0284; Eukaryota.
DR HOGENOM; CLU_000288_77_1_1; -.
DR OrthoDB; 5487329at2759; -.
DR Proteomes; UP000008984; Unassembled WGS sequence.
DR GO; GO:0000785; C:chromatin; IEA:EnsemblFungi.
DR GO; GO:0005847; C:mRNA cleavage and polyadenylation specificity factor complex; IEA:EnsemblFungi.
DR GO; GO:0180010; P:co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway; IEA:EnsemblFungi.
DR CDD; cd00200; WD40; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR045245; Pfs2-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR22836:SF0; PRE-MRNA 3' END PROCESSING PROTEIN WDR33; 1.
DR PANTHER; PTHR22836; WD40 REPEAT PROTEIN; 1.
DR Pfam; PF00400; WD40; 6.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 4.
PE 4: Predicted;
KW mRNA processing {ECO:0000256|RuleBase:RU369034};
KW Nucleus {ECO:0000256|RuleBase:RU369034};
KW Reference proteome {ECO:0000313|Proteomes:UP000008984};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT REPEAT 91..123
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 133..165
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 174..215
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 216..257
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 258..300
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 371..402
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 424..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 498..620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 430..444
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 498..536
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 553..587
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 597..620
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 620 AA; 67812 MW; F9F1244D8C8CC0D1 CRC64;
MAYEPRGDHG DRGGGQGQDG SYMKVRGRRP VTDYSASVLH WMRDRAPNYR GGYTGERERP
SASYIVDMIP PAGRPVSPAD SIPAKHLHSS LNKIKHPINV VRWTPEGRRL LTASTSGEFT
LWNGTGFNFE TIMQAHDSAI RALEYSHSDD WLISGDHDGV IKYWQPNFNN VKSINAHTDP
IRDLAFSPND SKFVTASDDS TLKIFDFALG QEELKLEGHG WDAKSVDWHP TKGLIISGSK
DHLVKLWDPR TARALTTLHG HKSTITKVLF EKKLGRCFAT SARDQTARVF DLRMMRDIVL
LKGHEKDIST LTFHPIHPNL LSTGGMDGSL FHYMLDTPNP PAGQPLTVAP YDSLDPESTP
AQSVWPTHKV PFAHDYAIWS LDWHPLGHIL ASGSNDRITR FWARARPGET EIFQDRYHIG
EAAAEAQGTW DRRGNRRQRQ EEEQRELEDE MDALVDQDAQ KPAVPGLTGG IPGLPLGGGA
VPGLGSAIPP PPMVPGVGVG GGSAAPPPPP PPPPFGIPGF NGAPPPPLPG LDPHNPPDPA
KLLELMQQAG VPIPPPGSLP PGLIPPPGGI PPPPGNFQLP IPPPLMNPSD LEASRRRAPL
PSQEESLRQE QRHGKYTRAR
//
