ID G0RXC7_HYPJQ Unreviewed; 438 AA.
AC G0RXC7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 24-JAN-2024, entry version 45.
DE RecName: Full=cellulase {ECO:0000256|ARBA:ARBA00012601};
DE EC=3.2.1.4 {ECO:0000256|ARBA:ARBA00012601};
GN Name=cel5b {ECO:0000313|EMBL:EGR44174.1};
GN ORFNames=TRIREDRAFT_82616 {ECO:0000313|EMBL:EGR44174.1};
OS Hypocrea jecorina (strain QM6a) (Trichoderma reesei).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX NCBI_TaxID=431241 {ECO:0000313|Proteomes:UP000008984};
RN [1] {ECO:0000313|EMBL:EGR44174.1, ECO:0000313|Proteomes:UP000008984}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=QM6a {ECO:0000313|EMBL:EGR44174.1,
RC ECO:0000313|Proteomes:UP000008984};
RX PubMed=18454138; DOI=10.1038/nbt1403;
RA Martinez D., Berka R.M., Henrissat B., Saloheimo M., Arvas M., Baker S.E.,
RA Chapman J., Chertkov O., Coutinho P.M., Cullen D., Danchin E.G.,
RA Grigoriev I.V., Harris P., Jackson M., Kubicek C.P., Han C.S., Ho I.,
RA Larrondo L.F., de Leon A.L., Magnuson J.K., Merino S., Misra M., Nelson B.,
RA Putnam N., Robbertse B., Salamov A.A., Schmoll M., Terry A., Thayer N.,
RA Westerholm-Parvinen A., Schoch C.L., Yao J., Barabote R., Nelson M.A.,
RA Detter C., Bruce D., Kuske C.R., Xie G., Richardson P., Rokhsar D.S.,
RA Lucas S.M., Rubin E.M., Dunn-Coleman N., Ward M., Brettin T.S.;
RT "Genome sequencing and analysis of the biomass-degrading fungus Trichoderma
RT reesei (syn. Hypocrea jecorina).";
RL Nat. Biotechnol. 26:553-560(2008).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Endohydrolysis of (1->4)-beta-D-glucosidic linkages in
CC cellulose, lichenin and cereal beta-D-glucans.; EC=3.2.1.4;
CC Evidence={ECO:0000256|ARBA:ARBA00000966};
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 5 (cellulase A) family.
CC {ECO:0000256|ARBA:ARBA00005641, ECO:0000256|RuleBase:RU361153}.
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DR EMBL; GL985099; EGR44174.1; -; Genomic_DNA.
DR RefSeq; XP_006969897.1; XM_006969835.1.
DR AlphaFoldDB; G0RXC7; -.
DR SMR; G0RXC7; -.
DR STRING; 431241.G0RXC7; -.
DR EnsemblFungi; EGR44174; EGR44174; TRIREDRAFT_82616.
DR GeneID; 18489491; -.
DR KEGG; tre:TRIREDRAFT_82616; -.
DR VEuPathDB; FungiDB:TRIREDRAFT_82616; -.
DR eggNOG; ENOG502QTP4; Eukaryota.
DR HOGENOM; CLU_029718_1_1_1; -.
DR OrthoDB; 1638835at2759; -.
DR Proteomes; UP000008984; Unassembled WGS sequence.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0000272; P:polysaccharide catabolic process; IEA:UniProt.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR001547; Glyco_hydro_5.
DR InterPro; IPR018087; Glyco_hydro_5_CS.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR34142:SF5; CBM1 DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR34142; ENDO-BETA-1,4-GLUCANASE A; 1.
DR Pfam; PF00150; Cellulase; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR PROSITE; PS00659; GLYCOSYL_HYDROL_F5; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361153};
KW Hydrolase {ECO:0000256|RuleBase:RU361153, ECO:0000313|EMBL:EGR44174.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000008984};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..438
FT /note="cellulase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003409107"
FT DOMAIN 59..308
FT /note="Glycoside hydrolase family 5"
FT /evidence="ECO:0000259|Pfam:PF00150"
FT REGION 354..416
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..400
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 438 AA; 46855 MW; 4CB5DF426A29D710 CRC64;
MRATSLLAAA LAVAGDALAG KIKYLGVAIP GIDFGCDIDG SCPTDTSSVP LLSYKGGDGA
GQMKHFAEDD GLNVFRISAT WQFVLNNTVD GKLDELNWGS YNKVVNACLE TGAYCMIDMH
NFARYNGGII GQGGVSDDIF VDLWVQIAKY YEDNDKIIFG LMNEPHDLDI EIWAQTCQKV
VTAIRKAGAT SQMILLPGTN FASVETYVST GSAEALGKIT NPDGSTDLLY FDVHKYLDIN
NSGSHAECTT DNVDAFNDFA DWLRQNKRQA IISETGASME PSCMTAFCAQ NKAISENSDV
YIGFVGWGAG SFDTSYILTL TPLGKPGNYT DNKLMNECIL DQFTLDEKYR PTPTSISTAA
EETATATATS DGDAPSTTKP IFREETASPT PNAVTKPSPD TSDSSDDDKD SAASMSAQGL
TGTVLFTVAA LGYMLVAF
//
