ID   G0S1E6_CHATD            Unreviewed;       613 AA.
AC   G0S1E6;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   24-JAN-2024, entry version 39.
DE   RecName: Full=methylcrotonoyl-CoA carboxylase {ECO:0000256|ARBA:ARBA00026116};
DE            EC=6.4.1.4 {ECO:0000256|ARBA:ARBA00026116};
DE   AltName: Full=3-methylcrotonyl-CoA carboxylase 2 {ECO:0000256|ARBA:ARBA00031404};
DE   AltName: Full=3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta {ECO:0000256|ARBA:ARBA00031237};
GN   ORFNames=CTHT_0013320 {ECO:0000313|EMBL:EGS22856.1};
OS   Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)
OS   (Thermochaetoides thermophila).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Chaetomiaceae; Thermochaetoides.
OX   NCBI_TaxID=759272 {ECO:0000313|Proteomes:UP000008066};
RN   [1] {ECO:0000313|EMBL:EGS22856.1, ECO:0000313|Proteomes:UP000008066}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 1495 / CBS 144.50 / IMI 039719
RC   {ECO:0000313|Proteomes:UP000008066};
RX   PubMed=21784248; DOI=10.1016/j.cell.2011.06.039;
RA   Amlacher S., Sarges P., Flemming D., van Noort V., Kunze R., Devos D.P.,
RA   Arumugam M., Bork P., Hurt E.;
RT   "Insight into structure and assembly of the nuclear pore complex by
RT   utilizing the genome of a eukaryotic thermophile.";
RL   Cell 146:277-289(2011).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=3-methyl-(2E)-butenoyl-CoA + ATP + hydrogencarbonate = 3-
CC         methyl-(2E)-glutaconyl-CoA + ADP + H(+) + phosphate;
CC         Xref=Rhea:RHEA:13589, ChEBI:CHEBI:15378, ChEBI:CHEBI:17544,
CC         ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:57344,
CC         ChEBI:CHEBI:57346, ChEBI:CHEBI:456216; EC=6.4.1.4;
CC         Evidence={ECO:0000256|ARBA:ARBA00029358};
CC   -!- PATHWAY: Amino-acid degradation; L-leucine degradation; (S)-3-hydroxy-
CC       3-methylglutaryl-CoA from 3-isovaleryl-CoA: step 2/3.
CC       {ECO:0000256|ARBA:ARBA00025711}.
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DR   EMBL; GL988039; EGS22856.1; -; Genomic_DNA.
DR   RefSeq; XP_006691848.1; XM_006691785.1.
DR   AlphaFoldDB; G0S1E6; -.
DR   STRING; 759272.G0S1E6; -.
DR   GeneID; 18255370; -.
DR   KEGG; cthr:CTHT_0013320; -.
DR   eggNOG; KOG0540; Eukaryota.
DR   HOGENOM; CLU_018822_0_1_1; -.
DR   OMA; AYLPIMS; -.
DR   OrthoDB; 5474505at2759; -.
DR   UniPathway; UPA00363; UER00861.
DR   Proteomes; UP000008066; Unassembled WGS sequence.
DR   GO; GO:0016874; F:ligase activity; IEA:InterPro.
DR   GO; GO:0006552; P:leucine catabolic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR034733; AcCoA_carboxyl_beta.
DR   InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR   InterPro; IPR011763; COA_CT_C.
DR   InterPro; IPR011762; COA_CT_N.
DR   InterPro; IPR045190; MCCB/AccD1-like.
DR   PANTHER; PTHR22855; ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED; 1.
DR   PANTHER; PTHR22855:SF13; METHYLCROTONOYL-COA CARBOXYLASE BETA CHAIN, MITOCHONDRIAL; 1.
DR   Pfam; PF01039; Carboxyl_trans; 1.
DR   SUPFAM; SSF52096; ClpP/crotonase; 2.
DR   PROSITE; PS50989; COA_CT_CTER; 1.
DR   PROSITE; PS50980; COA_CT_NTER; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000008066}.
FT   DOMAIN          108..365
FT                   /note="CoA carboxyltransferase N-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50980"
FT   DOMAIN          366..597
FT                   /note="CoA carboxyltransferase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS50989"
FT   REGION          15..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        20..38
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   613 AA;  66139 MW;  B529B3913E63946D CRC64;
     MSLSTQSREM LRLSRALGRQ TARPRSSPTS SASLIAPRTR TYHNLPQHAS LNHTKHQVSN
     KNGILGLAPT TKRTVATYTA PHHADAISII KSNLDTSSPE YKENERLMAE TMARLDELTR
     KIQQGGPPKA REKHLARKKM LPRDRITALI DPGTTFLELS PLAGHELYPE AEVPAGGIIT
     GVGVVEGVTC MIVANDSTVK GGTYYPITVK KHLRAQAIAQ ENKLPCIYLV DSGGANLPHQ
     ADVFPDREHF GRIFYNQARM SSQGIPQISV VMGPCTAGGA YVPAMSDESI IVQDQGHIFL
     AGPPLVKAAT GEVVSHEELG GGRMHSSVSG VTDYLAVDDA HAITLARRCV RNLNYPSTSS
     TIPSQTFDEP LYSPAELNGL APVNLRIPLP IHEVIARIVD GSRFAEFKRD YGTTLVTGFA
     HIYGHRVGIL ANNGILFSSS ALKGAHFIEL CAQRGIPLVF LQNISGFMVG RDAEREGIAK
     NGAKLVTAVA CADVPKFTVV VGGSYGAGNY GMCGRAYSPR FLWMWPNARI AVMGSEQLAS
     VMETVGSGKG ENGGLRERIE KESEAVYSSA RLWDDGVIPP AHTRRYLGLA LNAAMGGRNA
     VEPGQTKFGV FRM
//