ID G0S8L5_CHATD Unreviewed; 1272 AA.
AC G0S8L5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 24-JAN-2024, entry version 61.
DE SubName: Full=Putative transporter protein {ECO:0000313|EMBL:EGS21975.1};
GN ORFNames=CTHT_0038510 {ECO:0000313|EMBL:EGS21975.1};
OS Chaetomium thermophilum (strain DSM 1495 / CBS 144.50 / IMI 039719)
OS (Thermochaetoides thermophila).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Chaetomiaceae; Thermochaetoides.
OX NCBI_TaxID=759272 {ECO:0000313|Proteomes:UP000008066};
RN [1] {ECO:0000313|EMBL:EGS21975.1, ECO:0000313|Proteomes:UP000008066}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 1495 / CBS 144.50 / IMI 039719
RC {ECO:0000313|Proteomes:UP000008066};
RX PubMed=21784248; DOI=10.1016/j.cell.2011.06.039;
RA Amlacher S., Sarges P., Flemming D., van Noort V., Kunze R., Devos D.P.,
RA Arumugam M., Bork P., Hurt E.;
RT "Insight into structure and assembly of the nuclear pore complex by
RT utilizing the genome of a eukaryotic thermophile.";
RL Cell 146:277-289(2011).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Sugar
CC transporter (TC 2.A.1.1) family. {ECO:0000256|ARBA:ARBA00010992}.
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DR EMBL; GL988041; EGS21975.1; -; Genomic_DNA.
DR RefSeq; XP_006694271.1; XM_006694208.1.
DR AlphaFoldDB; G0S8L5; -.
DR GeneID; 18257889; -.
DR KEGG; cthr:CTHT_0038510; -.
DR eggNOG; KOG0062; Eukaryota.
DR eggNOG; KOG0254; Eukaryota.
DR HOGENOM; CLU_263823_0_0_1; -.
DR OrthoDB; 47478at2759; -.
DR Proteomes; UP000008066; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR CDD; cd03221; ABCF_EF-3; 1.
DR CDD; cd17356; MFS_HXT; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR032781; ABC_tran_Xtn.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR005828; MFS_sugar_transport-like.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003663; Sugar/inositol_transpt.
DR InterPro; IPR005829; Sugar_transporter_CS.
DR NCBIfam; TIGR00879; SP; 1.
DR PANTHER; PTHR48022:SF61; HIGH AFFINITY GLUCOSE TRANSPORTER RGT2; 1.
DR PANTHER; PTHR48022; PLASTIDIC GLUCOSE TRANSPORTER 4; 1.
DR Pfam; PF00005; ABC_tran; 2.
DR Pfam; PF12848; ABC_tran_Xtn; 1.
DR Pfam; PF00083; Sugar_tr; 1.
DR PRINTS; PR00171; SUGRTRNSPORT.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
DR PROSITE; PS50850; MFS; 1.
DR PROSITE; PS00216; SUGAR_TRANSPORT_1; 2.
DR PROSITE; PS00217; SUGAR_TRANSPORT_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008066};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 24..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 89..109
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 116..134
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 140..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 175..197
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 209..228
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 307..329
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 341..364
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 371..394
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 406..430
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 442..466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 29..501
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT DOMAIN 566..903
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT DOMAIN 1004..1240
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 927..946
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1210..1232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 717..767
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 928..946
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1212..1228
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1272 AA; 139633 MW; 1024475882DB327C CRC64;
MVGAVLFPIE GTADLRRVEA PVSFGAYLLC AFAAFGGIFF GYDTGWMSGV LGMPYFITMY
TGMQYDYEAG KPIGVDPTKF GLPSSTKSLM TSILSCGTFL GSLVAGDVAD YIGRRPTIIS
GCFVFCIGCS MQIASTNQTA LFVMGRLIAG LGVGFISAVI ILYMAEVAPR KVRGALVAGY
QFCITVGILL ANCVVYSTQA RNDPGSYRIP IGVQFIWAVI LGIGLFLLPE SPRYHVMKGM
IKEAAKDLSR VRGQPVDSNY IKDELAEIVA NHEYEMQVIP QMSYIGSWLA CFQGGFRRRG
GNLRRTLIGC GSQLFQQITG INFIFYFGVT FFQQLGTISD PFFMSLVTTL VNVVSTTISF
WAVEKIGRRP LLIYGGTGMV ISQLVVAVIG VTAGRPEEHN DAAVKTMIAF ICIFIFFFAS
TWGPVGWILV GELFPLPIRS RGVGISTASN WLFNMIIALV APYMVGNDEH SADLGPKVFF
IWGACCVGST LFAYFCVPEM KGLTLEQIDQ MMEETSARES TSESVATILV SCKQTRFDIK
CPNYRELDVE GLNITVTSRP VDNGEAKGRG KAKASEGTEI LSNAKLRLKA GGRYALVGRN
GTGKSTLMRA IAEKLIPGIP EETRISILQQ TSVKDVNADD LPETSGPSDG PSVLEEVIDK
ATSKTELEKE INALSTGLNS PFPHDAVFAL RKLRLDRMKK RLFVLDKDAR LRSGTRGLQA
RKALVEYEKQ VAAAEAQLSQ PPKEISSETL QAETQEAADL LGELQAQVEP SRMAEVEGNA
KKILMGLGFK EGDMAKSAGS LSGGWRMRAA LATALLKEAD ILILDEPTNF LDLFGILWLQ
KWLQHMEDTL ATPPTLVFVS HDRDFASSVC TDLIILKDKE LTYFHGDLPS YEAAQAEKRI
YLTKMKEAQD KQRAHMQESI RQNLIQGRKN DDQNKIRQAK SRQKRLEDRM GMQVNEKGGR
FKLNRDLVGW HTSSRAEIVV PQEERGVTIV LPDPTELRFP GSLISLEKVS FRYAGEKGQK
VRPPATLIDV SLTVGMGDRI GILGLNGAGK STLIRLLVGD PAPAGAKVTG NVTTHPRLKL
AYYSQHAVEA LQRLGQSDPS LTALSLLTSE VSPDAGLDES DIRGLLSSLG LRGNLVSSVP
IRRLSGGQLV RLELARLLWR RPLCLVLDEV TTHLDYETVT GLRKALREWE GAVVLVSHDR
WFMRGVVEGE RDNEDGEEEQ DEEEEEGRKD GEGVGRRRVV YKLAGGKLSL LEGGVREFEE
GMERRVGRLI GD
//
