ID G0TJB4_MYCCP Unreviewed; 367 AA.
AC G0TJB4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 24-JAN-2024, entry version 61.
DE SubName: Full=Putative alcohol dehydrogenase adh {ECO:0000313|EMBL:CCC43885.1};
GN Name=adh {ECO:0000313|EMBL:CCC43885.1};
GN OrderedLocusNames=MCAN_15531 {ECO:0000313|EMBL:CCC43885.1};
OS Mycobacterium canettii (strain CIPT 140010059).
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=1048245 {ECO:0000313|EMBL:CCC43885.1, ECO:0000313|Proteomes:UP000008896};
RN [1] {ECO:0000313|EMBL:CCC43885.1, ECO:0000313|Proteomes:UP000008896}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CIPT 140010059 {ECO:0000313|EMBL:CCC43885.1,
RC ECO:0000313|Proteomes:UP000008896};
RX PubMed=22389744; DOI=10.1371/journal.pntd.0001552;
RA Bentley S.D., Comas I., Bryant J.M., Walker D., Smith N.H., Harris S.R.,
RA Thurston S., Gagneux S., Wood J., Antonio M., Quail M.A., Gehre F.,
RA Adegbola R.A., Parkhill J., de Jong B.C.;
RT "The Genome of Mycobacterium Africanum West African 2 Reveals a Lineage-
RT Specific Locus and Genome Erosion Common to the M. tuberculosis Complex.";
RL PLoS Negl. Trop. Dis. 6:e1552-e1552(2012).
RN [2] {ECO:0000313|EMBL:CCC43885.1, ECO:0000313|Proteomes:UP000008896}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CIPT 140010059 {ECO:0000313|EMBL:CCC43885.1,
RC ECO:0000313|Proteomes:UP000008896};
RX PubMed=23291586; DOI=10.1038/ng.2517;
RA Supply P., Marceau M., Mangenot S., Roche D., Rouanet C., Khanna V.,
RA Majlessi L., Criscuolo A., Tap J., Pawlik A., Fiette L., Orgeur M.,
RA Fabre M., Parmentier C., Frigui W., Simeone R., Boritsch E.C., Debrie A.S.,
RA Willery E., Walker D., Quail M.A., Ma L., Bouchier C., Salvignol G.,
RA Sayes F., Cascioferro A., Seemann T., Barbe V., Locht C., Gutierrez M.C.,
RA Leclerc C., Bentley S.D., Stinear T.P., Brisse S., Medigue C., Parkhill J.,
RA Cruveiller S., Brosch R.;
RT "Genomic analysis of smooth tubercle bacilli provides insights into
RT ancestry and pathoadaptation of Mycobacterium tuberculosis.";
RL Nat. Genet. 45:172-179(2013).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|RuleBase:RU361277}.
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DR EMBL; HE572590; CCC43885.1; -; Genomic_DNA.
DR RefSeq; WP_003407690.1; NC_015848.1.
DR AlphaFoldDB; G0TJB4; -.
DR SMR; G0TJB4; -.
DR GeneID; 45425513; -.
DR KEGG; mce:MCAN_15531; -.
DR HOGENOM; CLU_026673_11_0_11; -.
DR OMA; GEYRRCE; -.
DR Proteomes; UP000008896; Chromosome.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd05188; MDR; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43401; L-THREONINE 3-DEHYDROGENASE; 1.
DR PANTHER; PTHR43401:SF2; L-THREONINE 3-DEHYDROGENASE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 31..148
FT /note="Alcohol dehydrogenase-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF08240"
FT DOMAIN 193..325
FT /note="Alcohol dehydrogenase-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00107"
SQ SEQUENCE 367 AA; 37997 MW; CE6FC6E7C33EFA2B CRC64;
MSDGAVVRAL VLEAPRRLVV RQYRLPRIGD DDALVRVEAC GLCGTDHEQY TGELAGGFAF
VPGHETVGTI AAIGPRAEQR WGVSAGDRVA VEVFQSCRQC ANCRGGEYRR CVRHGLADMY
GFIPVDREPG LWGGYAEYQY LAPDSMVLRV AGDLSPEVAT LFNPLGAGIR WGVTIPETKP
GDVVAVLGPG IRGLCAAAAA KGAGAGFVMV TGLGPRDADR LALAAQFGAD LAVDVAIDDP
VAALTEQTGG LADVVVDVTA KAPAAFAQAI ALARPAGTVV VAGTRGVGSG APGFSPDVVV
FKELRVLGAL GVDATAYRAA LDLLVSGRYP FASLPRRCVR LEGAEDLLAT MAGERDGVPP
IHGVLTP
//