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Database: UniProt
Entry: G0TK12_MYCCP
LinkDB: G0TK12_MYCCP
Original site: G0TK12_MYCCP 
ID   G0TK12_MYCCP            Unreviewed;      2126 AA.
AC   G0TK12;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   24-JAN-2024, entry version 65.
DE   SubName: Full=Putative polyketide synthase PKS7 {ECO:0000313|EMBL:CCC44002.1};
GN   Name=pks7 {ECO:0000313|EMBL:CCC44002.1};
GN   OrderedLocusNames=MCAN_16701 {ECO:0000313|EMBL:CCC44002.1};
OS   Mycobacterium canettii (strain CIPT 140010059).
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=1048245 {ECO:0000313|EMBL:CCC44002.1, ECO:0000313|Proteomes:UP000008896};
RN   [1] {ECO:0000313|EMBL:CCC44002.1, ECO:0000313|Proteomes:UP000008896}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CIPT 140010059 {ECO:0000313|EMBL:CCC44002.1,
RC   ECO:0000313|Proteomes:UP000008896};
RX   PubMed=22389744; DOI=10.1371/journal.pntd.0001552;
RA   Bentley S.D., Comas I., Bryant J.M., Walker D., Smith N.H., Harris S.R.,
RA   Thurston S., Gagneux S., Wood J., Antonio M., Quail M.A., Gehre F.,
RA   Adegbola R.A., Parkhill J., de Jong B.C.;
RT   "The Genome of Mycobacterium Africanum West African 2 Reveals a Lineage-
RT   Specific Locus and Genome Erosion Common to the M. tuberculosis Complex.";
RL   PLoS Negl. Trop. Dis. 6:e1552-e1552(2012).
RN   [2] {ECO:0000313|EMBL:CCC44002.1, ECO:0000313|Proteomes:UP000008896}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CIPT 140010059 {ECO:0000313|EMBL:CCC44002.1,
RC   ECO:0000313|Proteomes:UP000008896};
RX   PubMed=23291586; DOI=10.1038/ng.2517;
RA   Supply P., Marceau M., Mangenot S., Roche D., Rouanet C., Khanna V.,
RA   Majlessi L., Criscuolo A., Tap J., Pawlik A., Fiette L., Orgeur M.,
RA   Fabre M., Parmentier C., Frigui W., Simeone R., Boritsch E.C., Debrie A.S.,
RA   Willery E., Walker D., Quail M.A., Ma L., Bouchier C., Salvignol G.,
RA   Sayes F., Cascioferro A., Seemann T., Barbe V., Locht C., Gutierrez M.C.,
RA   Leclerc C., Bentley S.D., Stinear T.P., Brisse S., Medigue C., Parkhill J.,
RA   Cruveiller S., Brosch R.;
RT   "Genomic analysis of smooth tubercle bacilli provides insights into
RT   ancestry and pathoadaptation of Mycobacterium tuberculosis.";
RL   Nat. Genet. 45:172-179(2013).
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DR   EMBL; HE572590; CCC44002.1; -; Genomic_DNA.
DR   RefSeq; WP_014000873.1; NC_015848.1.
DR   GeneID; 45425631; -.
DR   KEGG; mce:MCAN_16701; -.
DR   HOGENOM; CLU_000022_35_2_11; -.
DR   OMA; GFACRLP; -.
DR   Proteomes; UP000008896; Chromosome.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR   GO; GO:0033068; P:macrolide biosynthetic process; IEA:UniProt.
DR   CDD; cd05195; enoyl_red; 1.
DR   CDD; cd08956; KR_3_FAS_SDR_x; 1.
DR   CDD; cd00833; PKS; 1.
DR   Gene3D; 3.30.70.3290; -; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   Gene3D; 3.40.50.11460; -; 1.
DR   Gene3D; 1.10.1200.10; ACP-like; 1.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR032821; PKS_assoc.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR042104; PKS_dehydratase_sf.
DR   InterPro; IPR020807; PKS_DH.
DR   InterPro; IPR020843; PKS_ER.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR015083; Polyketide_synth_docking.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF51; INACTIVE PHENOLPHTHIOCEROL SYNTHESIS POLYKETIDE SYNTHASE TYPE I PKS1-RELATED; 1.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF13602; ADH_zinc_N_2; 1.
DR   Pfam; PF08990; Docking; 1.
DR   Pfam; PF16197; KAsynt_C_assoc; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   Pfam; PF08659; KR; 1.
DR   Pfam; PF21089; PKS_DH_N; 1.
DR   Pfam; PF00550; PP-binding; 1.
DR   Pfam; PF14765; PS-DH; 1.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00826; PKS_DH; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SMART; SM00822; PKS_KR; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SMART; SM00823; PKS_PP; 1.
DR   SMART; SM01294; PKS_PP_betabranch; 1.
DR   SUPFAM; SSF47336; ACP-like; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 3.
DR   SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 1.
DR   PROSITE; PS50075; CARRIER; 1.
DR   PROSITE; PS00606; KS3_1; 1.
DR   PROSITE; PS52004; KS3_2; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   4: Predicted;
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          34..458
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          1976..2051
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   2126 AA;  221072 MW;  C25376F78BF76CE9 CRC64;
     MNSTPEDLVK ALRRSLKQNE RLKRENRDLL ARTTEPVAVV GMGCRYPGGV DSPETLWELV
     AHGRDAVSEF PADRGWDVAG LFDPDPDAVG KSYTRCGGFL TDVAGFDAEF FGIAPSEALA
     MDPQQRLLLE VSWEALERAG IDPITLRGSQ TGVFAGVFHG SYGGQGRVPG DLERYGLRGS
     TLSVASGRVA YVLGLQGPAV SVDTACSSSL VALHLAVQSL RLGECDLALV GGVTVMATPA
     MFIEFSRQRA LSADGRCKAY AGAADGTAFA EGAGVLVLAR LADARRLGHP VLALVRGSAV
     NQDGASNGLA TPNGPAQQRV ITAALASARL GVADVDVVEG HGTGTTLGDP IEAQAILATY
     GQRPADRPLW LGSIKSNIGH TSAAAGVAGV IKMVQAMRHG VLPKTLHVDV PTPHVDWSAG
     AVSLLTEPRP WHVPGRPRRA GVSSFGISGT NAHVILEQAP AVEPVGAAHG NDPVAVPWVL
     SARSAQALTN QARRLLAWVG ADENVRPLDV GWSLVNTRSL FDHRAVVVGA DRTQLMEGLT
     GLAAGVPGAD VVAGRAQTVG KTAFVFPGQG AQWLGMGAQL CATAPVFAEH IHRCERALRE
     HVEWSLLDVL RGAPGAPGLD RVDVVQPALW AVMVSLAELW RSVGVVPDAV IGHSQGEIAA
     AYVAGALSLR DAAAVVALRS RLLVRLGGAG GMVSLACGQP QAEKLASQWG DRLNIAAVNG
     VSSVVLAGET DAVTELMQRC EAEGIRARRI DVDYASHSAQ VDAIREELIA ALRGIEPRTS
     TVAFFSTVTG ELMDTAGVNA EYWYRSIRQP VQFERAVRNA FDGGYRVFVE SSPHPVLIAG
     IEETLVDCDR GATGEPIVIP TLGRDDGGVG RFWLSAGQAH VAGVGVDWRA AFADLGGRRV
     ELPTYGFARQ RFWLDGLGAV GGDLGGVGLV GAEHGLLAAV VQRPDSGGVV LTGRISVVAA
     PWLADHAVGP VVLFPGTGFV ELALRAGDEV GCSVLQELTL QAPLVLPAGG VRVQVVVGGV
     EQSGTRNVWV YSAAGQADSS PGWTLHAQGV LGVGSVQPAA ELSVWPPVGA RAMDVADGYQ
     VLAARGYGYG PAFRGLQALW RRGAEVFADV TLPEGVPIRG FGIHPAVLDA ALHAWGIVEG
     EQQTMLPFSW EGVCLHASGA ARVRVRLAPV GRGAVSVELA DPQGLPVLSV RQLMVRPVSA
     AALSRSTAGD RGLLEMIWTP VPLEGGDIGD DAVVWELPPH AGAQAGGDVL AAVYRGVHEV
     LEVLQSWLAS DVTGLGVVVT RGAVGPVDDD VTDLAGAAVW GLVRSAQAEH PGRVVLVDTD
     GSVAVEDAVG FGARSGEPQL VVRRGRVYAA RLAPVAAGLT LPSASAGGWR LVAGGGGTLA
     DVVVAPVAPV ELATGQVRVA VGAVGVNFRD VLVALGMYPG GGELGVDGAG VVVEVGPGVT
     GLAVGDRVMG LLGLVGSEAV VDARLVTMVP AGWSLVEAAA VPVAFLTAFY GLSVLAEVAA
     GQKVLVHAGT GGVGMAAVSL ARYWGAEVFV TASRAKWDTL RAMGFDDIHI SDSRSLEFEE
     AFLRATEGSG VDVVLNSLAG EFTDASLRLL PRGGRFIELG KTDIRDGQTV AERHRGVRYR
     AFDLVEAGPD RIAAMLSEVV GLLAAGVLAR LPVKTFDARC APAAYRFVSQ ARHIGKVVLT
     IPDGPGGQSG LAGGTVVVTG GTGMAGSAVA THLVRRHGVA NLVLVSRSGE QADRAAEVAA
     LLREGGAQVA VVSCDVADRD ALAALLAGLD PRYPLKGVFH AAGVLDDAVI TGLTPDRVDT
     VLRAKVDGAW NLHELTEDMD LSAFVVFSSM AGIVGTPAQG NYAAANAFLD GLVAYRRSRG
     LAGLSVAWGL WEQASAMTRH LGERDRARMT QAGLAPLTTE QALGFLDTAL QADRAVVVAA
     RLDRAALAGA GAALPALFSQ LAAGPTRRRI DAADTAVSMS GLVSRLHALT PERRQRELTD
     LVISNAAAVL GRSSSVDINA HKAFQDLGFD SLTAVELRNR LKTATGLTLS PTLIFDYPTP
     ATLAEHLDSR LVTASGSDQQ SLSDRVDDIT RELVVLLDQP DLSANVKAHL RTRLQTMLTS
     LTTEDDDIAA ATESQLFAIL DEELGS
//
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