ID G0U3Z4_TRYVY Unreviewed; 735 AA.
AC G0U3Z4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Probable helicase A859L {ECO:0000256|ARBA:ARBA00019253};
DE Flags: Fragment;
GN ORFNames=TVY486_1011990 {ECO:0000313|EMBL:CCC52156.1};
OS Trypanosoma vivax (strain Y486).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Duttonella.
OX NCBI_TaxID=1055687 {ECO:0000313|EMBL:CCC52156.1};
RN [1] {ECO:0000313|EMBL:CCC52156.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Y486 {ECO:0000313|EMBL:CCC52156.1};
RX PubMed=22331916; DOI=10.1073/pnas.1117313109;
RA Jackson A.P., Berry A., Aslett M., Allison H.C., Burton P.,
RA Vavrova-Anderson J., Brown R., Browne H., Corton N., Hauser H., Gamble J.,
RA Gilderthorp R., Marcello L., McQuillan J., Otto T.D., Quail M.A.,
RA Sanders M.J., van Tonder A., Ginger M.L., Field M.C., Barry J.D.,
RA Hertz-Fowler C., Berriman M.;
RT "Antigenic diversity is generated by distinct evolutionary mechanisms in
RT African trypanosome species.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:3416-3421(2012).
CC -!- FUNCTION: DNA helicase which seems to act as a postreplicative
CC transcription termination factor. Involved in ATP-dependent release of
CC nascent RNA. Forms a stable complex with single-stranded DNA, and to a
CC lesser extent RNA. {ECO:0000256|ARBA:ARBA00037581}.
CC -!- SIMILARITY: Belongs to the asfivirus helicase A859L family.
CC {ECO:0000256|ARBA:ARBA00007303}.
CC -!- SIMILARITY: Belongs to the helicase family. Poxviruses subfamily.
CC {ECO:0000256|ARBA:ARBA00038498}.
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DR EMBL; HE573026; CCC52156.1; -; Genomic_DNA.
DR AlphaFoldDB; G0U3Z4; -.
DR VEuPathDB; TriTrypDB:TvY486_1011990; -.
DR OrthoDB; 160114at2759; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR018306; Phage_T5_Orf172_DNA-bd.
DR PANTHER; PTHR11274:SF13; HELICASE A859L-RELATED; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF04851; ResIII; 1.
DR Pfam; PF10544; T5orf172; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00974; T5orf172; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000313|EMBL:CCC52156.1};
KW Helicase {ECO:0000313|EMBL:CCC52156.1};
KW Hydrolase {ECO:0000313|EMBL:CCC52156.1};
KW Late protein {ECO:0000256|ARBA:ARBA00022921};
KW Nucleotide-binding {ECO:0000313|EMBL:CCC52156.1}.
FT DOMAIN 248..427
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 460..609
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT NON_TER 735
FT /evidence="ECO:0000313|EMBL:CCC52156.1"
SQ SEQUENCE 735 AA; 83201 MW; 83DCADDB91F4E9B4 CRC64;
MVRFTMSVRC AHCFYVVQHP WLAAFGYVKV GYTRNPWRRL NTVSFTTCFT PEWSYFSVFE
CEGIKEAFLL EQAVLYVFED VRVSQRELIK CDPQPVVDVA RRICDKLNLN ALLKAEPEYH
LNTNGSLSPT GSQTDKSVGQ TVEELQSSTC ILRGHVEKLK ELRDSMRDDG FFSSYLGSSG
MQQEESKDNI TAEESECVFS DEEGVDALTD EEVEGELDYD FEDLAAPDEA YTITALRPYQ
AEAVDRCLAE LERSGAALCQ MACRCGKTPV AFKIIQHYIE KVSPIAVLFL VPSLGLLRQT
VKKLYGYGLR RVNFLLIGSC AETVMLDDGY ALTMTTDAET IKNTISSSTS QLVVISTYHS
SHIVCTMTGF NLAVFDECHR VCGSATPTNF NSVLLHSPCK RKLFLTATPA YNTPLRMDQV
NLFGNIAYRY YLREGIDAGY VNPFSLRIIL GEGMEDMNPY FFEAMKLVDK MIVYCGSIKH
ATELKVRLGE PPPGDVKPFV VLLAHSKMPS AVVSDVLRKF TVHKRCILLN VRLFQEGIEI
PDLNAVFFAA PRRSPRDIVQ SICRPLNKMD GKPSSYVFLP ATIDKKLPAD HPVNLEKFSE
LVPFTDALMD EDPVFFEYLI DPQKVSYDID VVGVRSLELS SGKIRKFVLP ALRRGVRYTN
QGRDRLHRAT SLPWKAAFGE LKRIVLECNR YPKNNDAWVI GERSISMMMF LKFVRKGYQQ
YLDGKTSSLQ MYQIR
//