GenomeNet

Database: UniProt
Entry: G0U3Z4_TRYVY
LinkDB: G0U3Z4_TRYVY
Original site: G0U3Z4_TRYVY 
ID   G0U3Z4_TRYVY            Unreviewed;       735 AA.
AC   G0U3Z4;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=Probable helicase A859L {ECO:0000256|ARBA:ARBA00019253};
DE   Flags: Fragment;
GN   ORFNames=TVY486_1011990 {ECO:0000313|EMBL:CCC52156.1};
OS   Trypanosoma vivax (strain Y486).
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Duttonella.
OX   NCBI_TaxID=1055687 {ECO:0000313|EMBL:CCC52156.1};
RN   [1] {ECO:0000313|EMBL:CCC52156.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Y486 {ECO:0000313|EMBL:CCC52156.1};
RX   PubMed=22331916; DOI=10.1073/pnas.1117313109;
RA   Jackson A.P., Berry A., Aslett M., Allison H.C., Burton P.,
RA   Vavrova-Anderson J., Brown R., Browne H., Corton N., Hauser H., Gamble J.,
RA   Gilderthorp R., Marcello L., McQuillan J., Otto T.D., Quail M.A.,
RA   Sanders M.J., van Tonder A., Ginger M.L., Field M.C., Barry J.D.,
RA   Hertz-Fowler C., Berriman M.;
RT   "Antigenic diversity is generated by distinct evolutionary mechanisms in
RT   African trypanosome species.";
RL   Proc. Natl. Acad. Sci. U.S.A. 109:3416-3421(2012).
CC   -!- FUNCTION: DNA helicase which seems to act as a postreplicative
CC       transcription termination factor. Involved in ATP-dependent release of
CC       nascent RNA. Forms a stable complex with single-stranded DNA, and to a
CC       lesser extent RNA. {ECO:0000256|ARBA:ARBA00037581}.
CC   -!- SIMILARITY: Belongs to the asfivirus helicase A859L family.
CC       {ECO:0000256|ARBA:ARBA00007303}.
CC   -!- SIMILARITY: Belongs to the helicase family. Poxviruses subfamily.
CC       {ECO:0000256|ARBA:ARBA00038498}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; HE573026; CCC52156.1; -; Genomic_DNA.
DR   AlphaFoldDB; G0U3Z4; -.
DR   VEuPathDB; TriTrypDB:TvY486_1011990; -.
DR   OrthoDB; 160114at2759; -.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR006935; Helicase/UvrB_N.
DR   InterPro; IPR014001; Helicase_ATP-bd.
DR   InterPro; IPR001650; Helicase_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR018306; Phage_T5_Orf172_DNA-bd.
DR   PANTHER; PTHR11274:SF13; HELICASE A859L-RELATED; 1.
DR   PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR   Pfam; PF00271; Helicase_C; 1.
DR   Pfam; PF04851; ResIII; 1.
DR   Pfam; PF10544; T5orf172; 1.
DR   SMART; SM00487; DEXDc; 1.
DR   SMART; SM00974; T5orf172; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR   PROSITE; PS51194; HELICASE_CTER; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000313|EMBL:CCC52156.1};
KW   Helicase {ECO:0000313|EMBL:CCC52156.1};
KW   Hydrolase {ECO:0000313|EMBL:CCC52156.1};
KW   Late protein {ECO:0000256|ARBA:ARBA00022921};
KW   Nucleotide-binding {ECO:0000313|EMBL:CCC52156.1}.
FT   DOMAIN          248..427
FT                   /note="Helicase ATP-binding"
FT                   /evidence="ECO:0000259|PROSITE:PS51192"
FT   DOMAIN          460..609
FT                   /note="Helicase C-terminal"
FT                   /evidence="ECO:0000259|PROSITE:PS51194"
FT   NON_TER         735
FT                   /evidence="ECO:0000313|EMBL:CCC52156.1"
SQ   SEQUENCE   735 AA;  83201 MW;  83DCADDB91F4E9B4 CRC64;
     MVRFTMSVRC AHCFYVVQHP WLAAFGYVKV GYTRNPWRRL NTVSFTTCFT PEWSYFSVFE
     CEGIKEAFLL EQAVLYVFED VRVSQRELIK CDPQPVVDVA RRICDKLNLN ALLKAEPEYH
     LNTNGSLSPT GSQTDKSVGQ TVEELQSSTC ILRGHVEKLK ELRDSMRDDG FFSSYLGSSG
     MQQEESKDNI TAEESECVFS DEEGVDALTD EEVEGELDYD FEDLAAPDEA YTITALRPYQ
     AEAVDRCLAE LERSGAALCQ MACRCGKTPV AFKIIQHYIE KVSPIAVLFL VPSLGLLRQT
     VKKLYGYGLR RVNFLLIGSC AETVMLDDGY ALTMTTDAET IKNTISSSTS QLVVISTYHS
     SHIVCTMTGF NLAVFDECHR VCGSATPTNF NSVLLHSPCK RKLFLTATPA YNTPLRMDQV
     NLFGNIAYRY YLREGIDAGY VNPFSLRIIL GEGMEDMNPY FFEAMKLVDK MIVYCGSIKH
     ATELKVRLGE PPPGDVKPFV VLLAHSKMPS AVVSDVLRKF TVHKRCILLN VRLFQEGIEI
     PDLNAVFFAA PRRSPRDIVQ SICRPLNKMD GKPSSYVFLP ATIDKKLPAD HPVNLEKFSE
     LVPFTDALMD EDPVFFEYLI DPQKVSYDID VVGVRSLELS SGKIRKFVLP ALRRGVRYTN
     QGRDRLHRAT SLPWKAAFGE LKRIVLECNR YPKNNDAWVI GERSISMMMF LKFVRKGYQQ
     YLDGKTSSLQ MYQIR
//
DBGET integrated database retrieval system