ID G0U8S8_TRYVY Unreviewed; 536 AA.
AC G0U8S8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Putative RNA-binding protein {ECO:0000313|EMBL:CCC54009.1};
GN ORFNames=TVY486_1114930 {ECO:0000313|EMBL:CCC54009.1};
OS Trypanosoma vivax (strain Y486).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Duttonella.
OX NCBI_TaxID=1055687 {ECO:0000313|EMBL:CCC54009.1};
RN [1] {ECO:0000313|EMBL:CCC54009.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Y486 {ECO:0000313|EMBL:CCC54009.1};
RX PubMed=22331916; DOI=10.1073/pnas.1117313109;
RA Jackson A.P., Berry A., Aslett M., Allison H.C., Burton P.,
RA Vavrova-Anderson J., Brown R., Browne H., Corton N., Hauser H., Gamble J.,
RA Gilderthorp R., Marcello L., McQuillan J., Otto T.D., Quail M.A.,
RA Sanders M.J., van Tonder A., Ginger M.L., Field M.C., Barry J.D.,
RA Hertz-Fowler C., Berriman M.;
RT "Antigenic diversity is generated by distinct evolutionary mechanisms in
RT African trypanosome species.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:3416-3421(2012).
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DR EMBL; HE573027; CCC54009.1; -; Genomic_DNA.
DR AlphaFoldDB; G0U8S8; -.
DR VEuPathDB; TriTrypDB:TvY486_1114930; -.
DR OrthoDB; 129723at2759; -.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd00590; RRM_SF; 1.
DR Gene3D; 3.30.70.330; -; 4.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR021790; PTBP1-like_RRM2.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR15592; MATRIN 3/NUCLEAR PROTEIN 220-RELATED; 1.
DR PANTHER; PTHR15592:SF18; SMOOTH, ISOFORM T; 1.
DR Pfam; PF00076; RRM_1; 1.
DR Pfam; PF13893; RRM_5; 1.
DR Pfam; PF11835; RRM_8; 1.
DR SMART; SM00360; RRM; 4.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR PROSITE; PS50102; RRM; 1.
PE 4: Predicted;
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 403..475
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 192..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 481..536
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 192..216
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..530
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 536 AA; 57713 MW; 0BD1D1826455F05F CRC64;
MQTFILRNIP AHCMEDDLRR ALLIYGTVLS AVVVPHLRQA TVTMRSPHEA QAVLQQGCIN
LFGQSVTVEP APYSPGTPQV GGGAAMMMPS HVGAARVNVV VEKCTYPVTK EVLTQVFSMV
APPINVVCSH SGPTTTGWVD FSDLATAQRA VMQLNKNSIY PDCCFMTLTV GQSVGTHHTM
GGYTTQALPY HRGAPHHHHQ SHHQSHGQHH PNGHHPHHVP LPPMHPLPGG NVGCGPMGLR
GGRGRGRIGP IGRGVHSFGP GLPGAHPPYA AAACNGPPPE AVVIVSGVPD TVALHDLWVL
LEVYGNVNSL KRQFSSKTNV IAHFQNVHDA RLAVQHLQGC PFHGSSLSLK HFAGYIERGG
KTEWNTGPAT DPSTHAVLFS SGYHHRTKPT AAFNPMGRVR PSKNLFISNL TTAITDDEIK
EIFTNAGFEL EAFYRKNSNV VIVSLSDVEN AVHALIAIHS QQIKERFLRV TFSHFPAAPR
YGAEEGSEPA AAPESELPVA AQEANGEAEK VAEDPVEEPT AETVEHLENE GLCEES
//
