ID G0UJ96_TRYCI Unreviewed; 2912 AA.
AC G0UJ96;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
DE Flags: Fragment;
GN ORFNames=TCIL3000_2_140 {ECO:0000313|EMBL:CCC89447.1};
OS Trypanosoma congolense (strain IL3000).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Nannomonas.
OX NCBI_TaxID=1068625 {ECO:0000313|EMBL:CCC89447.1};
RN [1] {ECO:0000313|EMBL:CCC89447.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=IL3000 {ECO:0000313|EMBL:CCC89447.1};
RX PubMed=22331916; DOI=10.1073/pnas.1117313109;
RA Jackson A.P., Berry A., Aslett M., Allison H.C., Burton P.,
RA Vavrova-Anderson J., Brown R., Browne H., Corton N., Hauser H., Gamble J.,
RA Gilderthorp R., Marcello L., McQuillan J., Otto T.D., Quail M.A.,
RA Sanders M.J., van Tonder A., Ginger M.L., Field M.C., Barry J.D.,
RA Hertz-Fowler C., Berriman M.;
RT "Antigenic diversity is generated by distinct evolutionary mechanisms in
RT African trypanosome species.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:3416-3421(2012).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; HE575315; CCC89447.1; -; Genomic_DNA.
DR VEuPathDB; TriTrypDB:TcIL3000_2_140; -.
DR OrthoDB; 8448at2759; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05171; PIKKc_ATM; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR038980; ATM_plant.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR044107; PIKKc_ATM.
DR PANTHER; PTHR37079; SERINE/THREONINE-PROTEIN KINASE ATM; 1.
DR PANTHER; PTHR37079:SF4; SERINE_THREONINE-PROTEIN KINASE ATM; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 2546..2864
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2880..2912
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 1016..1047
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1274..1305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2112..2134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1310..1341
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2217..2264
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1030..1044
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1274..1300
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:CCC89447.1"
SQ SEQUENCE 2912 AA; 324779 MW; E86B6D9DDE4FAAF4 CRC64;
LLHFVLRLYR LGIWHLPDKR SKCPYNHTKG SVVGKGDEKD AEELRDRSGE LQEGVEKDEH
LGDLYVLLSF PPQELFDQPT RVLDRLPTDS GKMYYAIMWI CRYLTTRFLR DSLIHNRAVL
RALLVLLHDV GGVFLSQSMA LWEPRQTILT FVGAVCRRTL NNGIKQLASW RPADISSMNT
AAAVHATMRL CCRLLGTITA LVRRTRVVSA SQDPLVNPEE ITSSVVNILV ENELITPGRT
TGDSSTCNEG GFQAVLKPRP FVPFVLASVD SLTYLLQVMR GVCGDARARS ALHALLETLF
KCYSHALYET VFVTFSYYAF KAKENKALTN SGAEARAVDF GEHQGRIGKE ARESHAIDAD
NLANSSKDWL HEEGRLLEFF VDRVSDNARG DFPPLTPQRQ CAIISAIYAL LFLCEGRTAE
KLSRYIFSFF SPGTAYIVRQ HTALKVRLLF SRFSGRVGSV MRELLASARE GMVSASCMSC
LTSLRAVGEA ARAVPSMEAR IVCTLLECWA TLGFVHKNLL LECLELIGDY AHSHGEGGGF
IWEPHTTTFT SKEDGPELLV SEGRGMSAQQ LCHYHREKLL FDWLWRLGHP LDALPVECFG
YSCVQQLWKS LMPLLIPLAM LCSTRHSTNV NEAYVNVEND VVANVFLQPN NLLWRLAACH
HHHEQKQGCL DDSAKADEEG GIDSVNDEQQ QQQKLVRTPE LLVSCITAHF ADVVARLLLY
ASLSKRGDTA KWITKFNGEP SNQCQTATLE QRGGSFSEEE EEHIKLEDAG YAGHVALEWL
RCTLSDRYVA LVRRNADAIL CRFVELVSAL SPYVGLEQLR AAVTLLCEAM GETHSTNIGL
GPLGMQDAGN QLLPHGPLFH GRVVDSFFAS DGGDHAYVLL QRVYVCITHN ANRGTRRVLL
ARIFRDIVKE WWSADLLRRV PHISHTVLRM CGNVLMSCLD LRHLVCDVLK HTWSVISTSP
VTNSSVGYYG VSAADKAFIS TIMLALVDES GVVSSTWETM KRLDRSLTQG RIEGSAESIH
NSQGAEEEVK SGSRQGEEEQ RIPEVSRGPT IGVKEAASCI KHMLTKLENV IFVSGAPASA
FYDEVASAVD HHRSAFVVLI RLYRLAKHQS TVNLLSAPPD SNSDGILNAA YHTYKMCCQS
VHHLLSIVCA DSSGHSPQSS IASATTYMAA AATGLQTTTR DAQLSAFRLL RALCWCFIES
GCESYVGSLF SPTADIHGLL QEYSLDQVLH RVYRQQLEQL YRLSFDADAC NAHIASTTLR
GWLCAGIKDT AEEGSFRDDP DSNVNMEERG VEEDKSVPKP RRPLGGSGTL IQQTLKLVEE
EEKLQQQNRE VREENQLYSS TCSFVRFADL VVFSRRLTNI PLHINAVRVD PVAERVTSLR
SSVVWDALRV HDDEPRFLRL FLVALIRQYK LQERLDTIAT VLNCVLLRTQ VKPKGEDGDS
NLSWFVEGFL PTTLLHVMLL KETQTQREER MYWSKCLEQY LFKHARRYPH TARLFLRAIN
VCRSAVMSSV RSRGVRVDVL DGGGRRNRSP SVGLDSYTSV AGITFPPFAR SEYGDPPDVS
DMKDSYWLSD IDPLALAAAA AACHEPHLAV LFAELSGESL LGCQRGIPSV VGEASATFVS
GTGAGAQSQK QSSVLFPSVN VEECHRSAVA TRPRHLRSDA AQHELARRLF DFRSAVHAIL
VDVKEALRLQ EDSYEEAPAG VYSGSGGFAV TSADVAITST GAKLTVPFQS SEQMEEHTTP
WEEAFLLRHP MRRIEQEKSR GNWKVVLSLL DSLVTHNGKH VDNRGSSRNG ISEARIVIEK
ANALMHLGDP GTALHILASA LERKLHTSLF EVSDDSRDVI YQPLQGRAEE EELKEGDCMQ
LRGALAGVMW RSGKWDLSCL HDSSYQQQRK LHNLLPPNIV TLDEGIYHAL KCMRHGEQHD
AQRWCAQAQQ HLLRQLDASN WRSIMLKAEA LQQIEDCSKT AMGAWLSEPP RWVNDSFPHV
RVPYDELQLL DSVQQRLCVA CKQPKWWLDH LGMCSERALR SNKPLLVQQW VSLYEELSGI
ISEDTVGAES GSDTRPGGVK KAMPALQELT SPYGLPATVF ISLVQARVEF ACGYPHRAIA
ILQNIEADYN LSTESPSAPG DRHQPPSPSF ALGGHSLPLP RNAPLMPPVV QQLVAWAMEA
RLVPLSQLVR DPFFHRSSVE DQSGCCSLQL ARLCHVLTRD IAERLRGHNY RVPQEDLESL
QQARAALQQR QEQIAASAVS REEKNLLRRR ISGLIAEREN DEREFVEELE AYALYRRSAL
NSYSRFMQMS GRDGNDNDIL AVFGFVSLWL HQDEQYVRRD TSPATGNIIT KAIQNTPLHK
FLPLYSQLVA QLGTSLDDKN LEDLVIRIAA VQPLRAVWPL LALANGHVFG PTAGGGRKGT
SSTGAVHVVD EKKVAMARRI LDSLKGPYAV TSTNNKNLGS LGSIKEEQSD KEALAFENGK
KLIKDAEKLS AAYIQLAFHH AEGSENRCIS IPKDFLLIKD ELSNLSIPPP TLSTTGCNYL
HLSSSPSASL AHQQLHIAHM SRVVRYERAF STPGGINLPK LIRCLLSDGR TVQQLLKSQD
DLRQDSMIQQ VFTLSNALFE KHPLTRQLRI YTYNVIPLAP TVGLIEWVDG TISLDRYLNS
SDGKCRSGAH ERYFPNETTS QRCRIMLSNA PKSQKHATLL SLYEGFSPAL HYFFLEHFFT
PQEWLQRREA YTRSVAASSM LGYVVGLGDR HANNLLLHVG RAELVHIDLG FAFDQGKLLP
IPELVPFRLT RNIVDGFGVQ GTEGPFRYHC EGALHLLRGQ KELLTIILAA CAHDPLTRWA
VKIDPTQKQK SSGNGLQNFM NCDSMRQQGV DVSRKRPTFT DAERVLTRVA EKIQGYESGE
LLSVRTHVQK LLQTAQNAEL LAQMYHGWSP WL
//
