ID G0UJQ0_TRYCI Unreviewed; 281 AA.
AC G0UJQ0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Vacuolar iron transporter 1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=TCIL3000_3_170 {ECO:0000313|EMBL:CCC89604.1};
OS Trypanosoma congolense (strain IL3000).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Nannomonas.
OX NCBI_TaxID=1068625 {ECO:0000313|EMBL:CCC89604.1};
RN [1] {ECO:0000313|EMBL:CCC89604.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=IL3000 {ECO:0000313|EMBL:CCC89604.1};
RX PubMed=22331916; DOI=10.1073/pnas.1117313109;
RA Jackson A.P., Berry A., Aslett M., Allison H.C., Burton P.,
RA Vavrova-Anderson J., Brown R., Browne H., Corton N., Hauser H., Gamble J.,
RA Gilderthorp R., Marcello L., McQuillan J., Otto T.D., Quail M.A.,
RA Sanders M.J., van Tonder A., Ginger M.L., Field M.C., Barry J.D.,
RA Hertz-Fowler C., Berriman M.;
RT "Antigenic diversity is generated by distinct evolutionary mechanisms in
RT African trypanosome species.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:3416-3421(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the CCC1 family.
CC {ECO:0000256|ARBA:ARBA00007049}.
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DR EMBL; HE575316; CCC89604.1; -; Genomic_DNA.
DR AlphaFoldDB; G0UJQ0; -.
DR VEuPathDB; TriTrypDB:TcIL3000_3_170; -.
DR OrthoDB; 5485588at2759; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005384; F:manganese ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0030026; P:intracellular manganese ion homeostasis; IEA:InterPro.
DR CDD; cd02434; Nodulin-21_like_3; 1.
DR InterPro; IPR008217; Ccc1_fam.
DR PANTHER; PTHR31851; FE(2+)/MN(2+) TRANSPORTER PCL1; 1.
DR PANTHER; PTHR31851:SF4; VACUOLAR IRON TRANSPORTER 1; 1.
DR Pfam; PF01988; VIT1; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 190..208
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 220..241
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 253..275
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 281 AA; 30627 MW; 7E8CAE8F08790903 CRC64;
MSETSKIDVR GVKCYKSVSN ARKAYESDDI EMSRREHQKP LYNEGHSPAA SDYVKSVVFG
GLDGIITSFT VVSAAVGSSS GAASVLIFGF SNVLADGFSM GFGEYIAGEA ERDNALSERR
REEWEVENAF DMEVDEMVQI YEMKGLSHED ATTIVKIISK DPKLFVDFMM TEELGIIINM
DDKHGPKKQG LVMFLSFIIF GTVPLLAYVP GKGKGIDGVF LLSCFFATCA LLGLGMLKGY
LSGVSMVRSS MLMVLNGVIS GTFSFTVGAC LERLLRSKVS E
//
