ID G0UMS8_TRYCI Unreviewed; 719 AA.
AC G0UMS8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Putative cell division control protein {ECO:0000313|EMBL:CCC90486.1};
GN ORFNames=TCIL3000_5_1920 {ECO:0000313|EMBL:CCC90486.1};
OS Trypanosoma congolense (strain IL3000).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Nannomonas.
OX NCBI_TaxID=1068625 {ECO:0000313|EMBL:CCC90486.1};
RN [1] {ECO:0000313|EMBL:CCC90486.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=IL3000 {ECO:0000313|EMBL:CCC90486.1};
RX PubMed=22331916; DOI=10.1073/pnas.1117313109;
RA Jackson A.P., Berry A., Aslett M., Allison H.C., Burton P.,
RA Vavrova-Anderson J., Brown R., Browne H., Corton N., Hauser H., Gamble J.,
RA Gilderthorp R., Marcello L., McQuillan J., Otto T.D., Quail M.A.,
RA Sanders M.J., van Tonder A., Ginger M.L., Field M.C., Barry J.D.,
RA Hertz-Fowler C., Berriman M.;
RT "Antigenic diversity is generated by distinct evolutionary mechanisms in
RT African trypanosome species.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:3416-3421(2012).
CC -!- SIMILARITY: Belongs to the CEF1 family.
CC {ECO:0000256|ARBA:ARBA00010506}.
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DR EMBL; HE575318; CCC90486.1; -; Genomic_DNA.
DR AlphaFoldDB; G0UMS8; -.
DR VEuPathDB; TriTrypDB:TcIL3000_5_1920; -.
DR OrthoDB; 131128at2759; -.
DR GO; GO:0000974; C:Prp19 complex; IEA:InterPro.
DR GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0000398; P:mRNA splicing, via spliceosome; IEA:InterPro.
DR CDD; cd00167; SANT; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 2.
DR InterPro; IPR047242; CDC5L/Cef1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR PANTHER; PTHR45885; CELL DIVISION CYCLE 5-LIKE PROTEIN; 1.
DR PANTHER; PTHR45885:SF1; CELL DIVISION CYCLE 5-LIKE PROTEIN; 1.
DR Pfam; PF13921; Myb_DNA-bind_6; 1.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR SMART; SM00717; SANT; 2.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS51294; HTH_MYB; 2.
DR PROSITE; PS50090; MYB_LIKE; 2.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000313|EMBL:CCC90486.1};
KW Cell division {ECO:0000313|EMBL:CCC90486.1};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Spliceosome {ECO:0000256|ARBA:ARBA00022728}.
FT DOMAIN 3..58
FT /note="HTH myb-type"
FT /evidence="ECO:0000259|PROSITE:PS51294"
FT DOMAIN 3..54
FT /note="Myb-like"
FT /evidence="ECO:0000259|PROSITE:PS50090"
FT DOMAIN 63..115
FT /note="HTH myb-type"
FT /evidence="ECO:0000259|PROSITE:PS51294"
FT DOMAIN 64..111
FT /note="Myb-like"
FT /evidence="ECO:0000259|PROSITE:PS50090"
FT REGION 290..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 660..715
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 719 AA; 79671 MW; 9C7FA189F28C70C5 CRC64;
MTRLRFKGGA WTNTEDEVLR ASLTVYGLQN WERVASTLGR KTAAQCRERW ENFLDPRLNI
QEAWTPEEEE QLVQLQSLFP NQWNLIAREI MHRCNMNRPA WLCEEYYHSL LDALEYKRSR
EAGDAKSSSK LTLEEFLEER KRQRGVHRGI ETRDARPDAV DMETSDKEMV EFTVSRLANQ
DGKKGLRKER KKQLEHTSFL AKLQSNREAI ESGTLSARAK KRMERAMLED RSGSSNTNLL
DTIVEDHQDD SEGVEGRTDK QRAKFQPIDL DTDKRAAGIQ AKQRVLVKEF SATAEPDEGR
PSSKGSAPNG VNLEMLRIGN AAAKTSKPLL ESKKGVALLK DIVDASGDVS AKRCPVEPPR
DVAGDVVDLD SLFASLPGVV GAPRRPAAEE EAFDVDGPFT GLPGPISVDR KAERVSAAIF
VPRNEELEES ALSHSVEPVL DVQLPLDFSS SLGQALLAKS KRLVTDMSRQ MLTGCMGLHR
DPSAHSGNDC GERVIAEEGV GSYGQNVDFL PDSDEINLVR ILVANQMDTT PERLLGFGSV
QEKIPVKVNK QLAFTNEGHG SVGDLWRDVS AAEAMRQVGD QLQQRRDRVT SLLEGRSNSS
EERNARRCPE HIIRVCFSPS HGPADASSMS ACSESGAGRG SVDDASQRLA AACAYWSGEL
QEAQRKLAFY TAVSEAERRE ISQRLNSVGS KLEAAEQEER NLQEAYRTAQ IAVERANTG
//
