ID G0UW10_TRYCI Unreviewed; 347 AA.
AC G0UW10;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=3-dehydrosphinganine reductase {ECO:0000256|ARBA:ARBA00026112};
DE EC=1.1.1.102 {ECO:0000256|ARBA:ARBA00026112};
GN ORFNames=TCIL3000_10_3370 {ECO:0000313|EMBL:CCC93576.1};
OS Trypanosoma congolense (strain IL3000).
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Nannomonas.
OX NCBI_TaxID=1068625 {ECO:0000313|EMBL:CCC93576.1};
RN [1] {ECO:0000313|EMBL:CCC93576.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=IL3000 {ECO:0000313|EMBL:CCC93576.1};
RX PubMed=22331916; DOI=10.1073/pnas.1117313109;
RA Jackson A.P., Berry A., Aslett M., Allison H.C., Burton P.,
RA Vavrova-Anderson J., Brown R., Browne H., Corton N., Hauser H., Gamble J.,
RA Gilderthorp R., Marcello L., McQuillan J., Otto T.D., Quail M.A.,
RA Sanders M.J., van Tonder A., Ginger M.L., Field M.C., Barry J.D.,
RA Hertz-Fowler C., Berriman M.;
RT "Antigenic diversity is generated by distinct evolutionary mechanisms in
RT African trypanosome species.";
RL Proc. Natl. Acad. Sci. U.S.A. 109:3416-3421(2012).
CC -!- PATHWAY: Lipid metabolism; sphingolipid metabolism.
CC {ECO:0000256|ARBA:ARBA00004760}.
CC -!- PATHWAY: Sphingolipid metabolism. {ECO:0000256|ARBA:ARBA00004991}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|RuleBase:RU000363}.
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DR EMBL; HE575323; CCC93576.1; -; Genomic_DNA.
DR AlphaFoldDB; G0UW10; -.
DR VEuPathDB; TriTrypDB:TcIL3000_10_3370; -.
DR OrthoDB; 7812at2759; -.
DR GO; GO:0047560; F:3-dehydrosphinganine reductase activity; IEA:InterPro.
DR GO; GO:0006666; P:3-keto-sphinganine metabolic process; IEA:InterPro.
DR GO; GO:0030148; P:sphingolipid biosynthetic process; IEA:InterPro.
DR CDD; cd08939; KDSR-like_SDR_c; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR045022; KDSR-like.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR43550; 3-KETODIHYDROSPHINGOSINE REDUCTASE; 1.
DR PANTHER; PTHR43550:SF3; 3-KETODIHYDROSPHINGOSINE REDUCTASE; 1.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SMART; SM00822; PKS_KR; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Sphingolipid metabolism {ECO:0000256|ARBA:ARBA00022919}.
SQ SEQUENCE 347 AA; 37974 MW; 0C063CC80D2E47FF CRC64;
MIICTVCAAL FGVIVVAVWW SVHRVPLFPI NGCCALVTGG SLGIGLETAR ELVRRGARLV
IIAARNEETL KTAVEELRTE VVGRDTKVEY VVMDVADETS VSRALEEVMR TLQTTGKAAL
DLVVCNAGFS VPSRFVDITP AEGRRMMDVN FFGCVNVVRA VLPSMLQQRG GRFVFVSSLA
ARCPLAGYSI YAASKAAIRA FAHSLDMENS YKGVRCQVIS PPDVYTPGLE QENLRKSPEC
SALSSFGGDA PVTAADMGRR VTNSIVNYRF DESIGFDKQL LCWAVAGTEP ATGVLELFMQ
FLFSGWLRLF LAVLSKLHYN IVLRVRVDEE KKKKPEPVGT GQLKKNL
//
