ID G0V9M5_NAUCC Unreviewed; 1602 AA.
AC G0V9M5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE RecName: Full=VPS10 domain-containing protein {ECO:0000259|SMART:SM00602};
GN Name=NCAS0B05570 {ECO:0000313|EMBL:CCC68641.1};
GN OrderedLocusNames=NCAS_0B05570 {ECO:0000313|EMBL:CCC68641.1};
OS Naumovozyma castellii (strain ATCC 76901 / BCRC 22586 / CBS 4309 / NBRC
OS 1992 / NRRL Y-12630) (Yeast) (Saccharomyces castellii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Naumovozyma.
OX NCBI_TaxID=1064592 {ECO:0000313|EMBL:CCC68641.1, ECO:0000313|Proteomes:UP000001640};
RN [1] {ECO:0000313|EMBL:CCC68641.1, ECO:0000313|Proteomes:UP000001640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 76901 / BCRC 22586 / CBS 4309 / NBRC 1992 / NRRL Y-12630
RC {ECO:0000313|Proteomes:UP000001640};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Type strain:CBS 4309;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Genome sequence of Naumovozyma castellii.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; HE576753; CCC68641.1; -; Genomic_DNA.
DR RefSeq; XP_003675013.1; XM_003674965.1.
DR STRING; 1064592.G0V9M5; -.
DR GeneID; 11525050; -.
DR KEGG; ncs:NCAS_0B05570; -.
DR eggNOG; KOG3511; Eukaryota.
DR HOGENOM; CLU_000700_0_1_1; -.
DR InParanoid; G0V9M5; -.
DR OMA; KANDGTC; -.
DR OrthoDB; 5840at2759; -.
DR Proteomes; UP000001640; Chromosome 2.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR CDD; cd15482; Sialidase_non-viral; 1.
DR Gene3D; 2.10.70.80; -; 1.
DR Gene3D; 2.120.10.10; -; 1.
DR Gene3D; 3.30.60.270; -; 2.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF27; VPS10 HOMOLOG 1-RELATED; 1.
DR Pfam; PF15902; Sortilin-Vps10; 2.
DR Pfam; PF15901; Sortilin_C; 2.
DR SMART; SM00602; VPS10; 2.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 3.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001640};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1602
FT /note="VPS10 domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003410681"
FT TRANSMEM 1423..1442
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 47..740
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
FT DOMAIN 778..1410
FT /note="VPS10"
FT /evidence="ECO:0000259|SMART:SM00602"
FT REGION 152..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 411..433
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1538..1602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 161..176
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1602 AA; 178635 MW; 2876B44DC6C438B6 CRC64;
MKLFSWLPIC GIVISLLNLT LAADEFVPKV TRTISKLSFN VAAFDDSTIL LKLEDNVLYR
TTNNGETWNP VKGIDGDVIW VDIDEFNSHD RAFVTSRKLG EFYVTDDQGD SWRKISIDVP
DNGDPSPCGL FTHPTNKDFL NVRCNVCEKR AQNQPREADK NPKPSVPPPP PPGKEIGNLY
NPNRPRCQLL TFVSKNNGKS FTQIKAPSFD ASKKDHLETT QCSFIRSTKG SQLGDSESNL
LCLYKVVEEN SEKSTLERTI TDLFVTSDWG KTVKSLDTFK DLAISSFNVL DSSILIQTNE
DAYNSNSAKK LWVSRDGVTF KEAYLPTELR YSISGKITED SVGRIILPIN AKKTEDEKDT
SVLAEILISD SSGLKFEPFE WSKADIRGYS QLSQPKHLKG TMLGSFFPRN RRARKGSKKQ
QEKSSSKGIT KISVDNGQSW SNLRIVDSKN KDLFPCDIDD VEKCSLHIPM MLFGSDDYVS
AGIMMAVGFA GDGSNSDWEN EQTFLSRDGG LTWQLAFEFP TVFAMGDSGN VIVAVPFNPE
EDDDPEAEFY YSLDQGKSWT EYQLQKPIIP VTLTSTTPDG SGLNFVLSGM DFSQPKASSD
SNFIYAIDFS ELFNGKICKT DDFETWSLAE GKCVAGVKYS YSRRKQDAKC ISKKLFEDLQ
LKEEICDQCT KDDYECSFEF SKDQNGGCVP DYKLLSLSGA CSKAKNDAIQ LKPMQLISGT
KCKKELQVDT VNVPCKGVPD SNKHKDKGKN RGEPIVVTEN SFDGKMMFYQ YFDSIDHESV
ILGDTDGKYY ISHDGGQTMQ PFDSDGESIV EVVFNPYFNT SAYLFGKDGT LFVTNDGGYT
FTTTELPDTI QLGFPLDFHA KDEKTFIYYG GKNCDSILSA DCHPVAYITK DGGQTFKELL
DSTIHCEFCG SQYKHPYDQN MIICQVKETG STKRTLVSST DYFKNDKKVI FDNILGYMSD
GEFSIVAVIH DEKELRTYVS ADGDEFAEAK LPQDLENIKQ KAFTVIPAHS PSVFLHYTTN
SGRGVSFGRL LKSNSNGTSF VTLEPGVNRN DAGLVDFEKI QGLEGIMVIN VVDNLEQVRS
KNEAKKLKTK VTFNDGADWD FLKPPTKDSN GKKYSCSSKN LNKCSLNLHG YTERSDFRDT
YSSGSALGYM VGIGNVGEYL QSYDEASTFL TTDGGLTWSE IKKGAYQYEY GDHGGIIVLV
ADKTATDTLS YSLDAGKTWT DYKFADEKII VDDLITVPKD SAMRFLLIGQ SSSIRGANTK
TFTIDFSGSF KRQCILDVDN EDSDDFDYFS LNPSKSECLF GHQKQYLHKI HDDCFVGNVP
LTDFTRITKN CSCTRNDFEC DYNFYKANDG TCKLVEGLTP IPASDICKKN PDLIEFSEPT
GYRMIPLSTC QGGLKLHVAA DTYPCPGKEQ EFNTLHGIAG RSFILIFLIP FIIFVLVAWF
VYVRGIRRNG GFARFGEIRL GEDDLIENNG TDKAVNYIVK TGLYLFSGIY AGYQLAKRST
NGLLSKWQNR SNRRGPSYSS LLDDQFLDDA DDLLTGHDED ANDLSSFADQ DSNFDIDEDS
IPPEIVPQPY SDEHPADTPA VETDDVPAAE QETEASTNTD TT
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