ID G0VA22_NAUCC Unreviewed; 806 AA.
AC G0VA22;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 13-SEP-2023, entry version 55.
DE RecName: Full=XPG N-terminal domain-containing protein {ECO:0008006|Google:ProtNLM};
GN Name=NCAS0B06680 {ECO:0000313|EMBL:CCC68752.1};
GN OrderedLocusNames=NCAS_0B06680 {ECO:0000313|EMBL:CCC68752.1};
OS Naumovozyma castellii (strain ATCC 76901 / BCRC 22586 / CBS 4309 / NBRC
OS 1992 / NRRL Y-12630) (Yeast) (Saccharomyces castellii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Naumovozyma.
OX NCBI_TaxID=1064592 {ECO:0000313|EMBL:CCC68752.1, ECO:0000313|Proteomes:UP000001640};
RN [1] {ECO:0000313|EMBL:CCC68752.1, ECO:0000313|Proteomes:UP000001640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 76901 / BCRC 22586 / CBS 4309 / NBRC 1992 / NRRL Y-12630
RC {ECO:0000313|Proteomes:UP000001640};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Type strain:CBS 4309;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Genome sequence of Naumovozyma castellii.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the XPG/RAD2 endonuclease family.
CC {ECO:0000256|ARBA:ARBA00024023}.
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DR EMBL; HE576753; CCC68752.1; -; Genomic_DNA.
DR RefSeq; XP_003675123.1; XM_003675075.1.
DR AlphaFoldDB; G0VA22; -.
DR STRING; 1064592.G0VA22; -.
DR GeneID; 11524812; -.
DR KEGG; ncs:NCAS_0B06680; -.
DR eggNOG; ENOG502QVHA; Eukaryota.
DR HOGENOM; CLU_378548_0_0_1; -.
DR InParanoid; G0VA22; -.
DR OMA; FYQTKVI; -.
DR OrthoDB; 6876at2759; -.
DR Proteomes; UP000001640; Chromosome 2.
DR GO; GO:0004518; F:nuclease activity; IEA:InterPro.
DR GO; GO:0006974; P:DNA damage response; IEA:UniProt.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR CDD; cd09902; H3TH_MKT1; 1.
DR CDD; cd09858; PIN_MKT1; 1.
DR Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR InterPro; IPR022039; MKT1_C.
DR InterPro; IPR037314; MKT1_H3TH.
DR InterPro; IPR022040; MKT1_N.
DR InterPro; IPR029060; PIN-like_dom_sf.
DR InterPro; IPR006086; XPG-I_dom.
DR InterPro; IPR006084; XPG/Rad2.
DR InterPro; IPR006085; XPG_DNA_repair_N.
DR PANTHER; PTHR11081; FLAP ENDONUCLEASE FAMILY MEMBER; 1.
DR PANTHER; PTHR11081:SF32; POST-TRANSCRIPTIONAL REGULATOR MKT1; 1.
DR Pfam; PF12246; MKT1_C; 1.
DR Pfam; PF12247; MKT1_N; 1.
DR Pfam; PF00752; XPG_N; 1.
DR SMART; SM00484; XPGI; 1.
DR SMART; SM00485; XPGN; 1.
DR SUPFAM; SSF88723; PIN domain-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001640};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845}.
FT DOMAIN 1..103
FT /note="XPG N-terminal"
FT /evidence="ECO:0000259|SMART:SM00485"
FT DOMAIN 183..252
FT /note="XPG-I"
FT /evidence="ECO:0000259|SMART:SM00484"
FT REGION 340..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 343..358
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 359..378
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 806 AA; 92100 MW; 14D7487372CA740A CRC64;
MPIKSLESYL FERGLVGSYP IESLKNATLG IDVNHYVSRL LTSKKEQFLD AIGGFPLSLK
MYLESDLKIF KEYKITPVFV FNGSLVFNQL ESSGYFTASA AEASSSSNLD ISIPSGSPGT
QTIKTNRELL LAQRHKGWTQ WSNLMTTSSK TYIDQPIQPQ EPFRYSTSIE YTRYQSNLIN
YFIDHDITYQ VAPYSSWLQL AYLLEESYID AIYGPTDCLM LKNIDKFILG MEFPNKDFRF
IEKSRVLKEF RCSQDEFVDI AMAVGNDLQP TTLPPLQIYP GSKVFDFALE MVLNTGTNFY
AYQLSNPVKE ESAKYVLKYE KGISSLRYMP VLKDSGKVEV YMPNRPSKDK KDIKSKSPDT
TSSSESVSDS TSSDPQIPND VHDFIAQQLP SEYYFYRSLG LVSGRLFDAI TTGVYPEEPP
LDGGSSDSYR ELIKLSVDTF KNKEINLLTQ PINRYYQMKP IKQVKWFSPG SSTQLTNRVS
PSIFEKTNRL VVKTDDVNKV FSIGEFINTL NESTDLSKSF VSEKVIFPNS VPKADKLFAS
FDLLSTSFLR MLYQLEFFDF DSSKNLLKPT KWGTILLKLN ELEISANYFE SILIFLMFVK
MNVLSLSEEL KPVVRFALSD STLRSYPQES QYVLLITRIL TLFQVDQKPT NYHGPIDKRT
LVFREHLDFI KKNMNELYEA TIVSSLTANE FDRLSLDNNE WQKNIVRNAP FKSSSPNTLM
AMMWEFFLQK YLHNGNVKTD AMAMVATEFG TYKSIPNLEE QFEISHEFLV QVSKVMQELT
SVGLLKKGDQ NSFEQAVKFS EDAISG
//
