ID G0VAY4_NAUCC Unreviewed; 309 AA.
AC G0VAY4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 24-JAN-2024, entry version 51.
DE RecName: Full=GTP-binding protein {ECO:0000256|RuleBase:RU367014};
GN Name=NCAS0B00230 {ECO:0000313|EMBL:CCC68107.1};
GN OrderedLocusNames=NCAS_0B00230 {ECO:0000313|EMBL:CCC68107.1};
OS Naumovozyma castellii (strain ATCC 76901 / BCRC 22586 / CBS 4309 / NBRC
OS 1992 / NRRL Y-12630) (Yeast) (Saccharomyces castellii).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Naumovozyma.
OX NCBI_TaxID=1064592 {ECO:0000313|EMBL:CCC68107.1, ECO:0000313|Proteomes:UP000001640};
RN [1] {ECO:0000313|EMBL:CCC68107.1, ECO:0000313|Proteomes:UP000001640}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 76901 / BCRC 22586 / CBS 4309 / NBRC 1992 / NRRL Y-12630
RC {ECO:0000313|Proteomes:UP000001640};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
RN [2]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Type strain:CBS 4309;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Genome sequence of Naumovozyma castellii.";
RL Submitted (AUG-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: GTPase involved in activation of the TORC1 signaling pathway,
CC which promotes growth and represses autophagy in nutrient-rich
CC conditions. {ECO:0000256|RuleBase:RU367014}.
CC -!- SUBUNIT: Component of the GSE complex. {ECO:0000256|RuleBase:RU367014}.
CC -!- SIMILARITY: Belongs to the GTR/RAG GTP-binding protein family.
CC {ECO:0000256|ARBA:ARBA00007756, ECO:0000256|RuleBase:RU367014}.
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DR EMBL; HE576753; CCC68107.1; -; Genomic_DNA.
DR RefSeq; XP_003674484.1; XM_003674436.1.
DR AlphaFoldDB; G0VAY4; -.
DR STRING; 1064592.G0VAY4; -.
DR GeneID; 11525005; -.
DR KEGG; ncs:NCAS_0B00230; -.
DR eggNOG; KOG3886; Eukaryota.
DR HOGENOM; CLU_044099_0_0_1; -.
DR InParanoid; G0VAY4; -.
DR OMA; QQKDHIF; -.
DR OrthoDB; 33171at2759; -.
DR Proteomes; UP000001640; Chromosome 2.
DR GO; GO:1990131; C:Gtr1-Gtr2 GTPase complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR CDD; cd11384; RagA_like; 1.
DR Gene3D; 3.30.450.190; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR006762; Gtr1_RagA.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039397; RagA/B.
DR PANTHER; PTHR11259; RAS-RELATED GTP BINDING RAG/GTR YEAST; 1.
DR PANTHER; PTHR11259:SF1; RAS-RELATED GTP-BINDING PROTEIN; 1.
DR Pfam; PF04670; Gtr1_RagA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU367014};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU367014};
KW Reference proteome {ECO:0000313|Proteomes:UP000001640}.
SQ SEQUENCE 309 AA; 35640 MW; 2733BC86642B71AD CRC64;
MSTPMNATSN NRKKLLLMGR SGSGKSSMRS IIFSNYSAFD TRRLGATIDV EHSHLRFLGN
MTLNLWDCGG QDVFMENYFT KQKDHIFQMV QVLIHVFDVE STDVIKDIEI FTRALKQLKK
YSPEAKIFVL LHKMDLVQLD KRNDLFEIMM GKLQETSSEF GFPNLVGFPT SIWDESLYKA
WSQIVCSLIP NMTIHQSNLK SLKSILNAYE IILFERTTFL VICSSNMNMQ NGGVEVLDPK
IFEKISNIMK NFKQNCTKLK SEFRTLILND SIYVCELSSN MVCFIVLNDP NDSREMVLEN
IRKAKELFQ
//
