ID G0WFN4_NAUDC Unreviewed; 1056 AA.
AC G0WFN4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=DNA mismatch repair protein MSH3 {ECO:0000256|ARBA:ARBA00019000};
DE AltName: Full=DNA mismatch repair protein msh3 {ECO:0000256|ARBA:ARBA00022151};
DE AltName: Full=MutS protein homolog 3 {ECO:0000256|ARBA:ARBA00029792};
GN Name=NDAI0I00260 {ECO:0000313|EMBL:CCD26595.1};
GN OrderedLocusNames=NDAI_0I00260 {ECO:0000313|EMBL:CCD26595.1};
OS Naumovozyma dairenensis (strain ATCC 10597 / BCRC 20456 / CBS 421 / NBRC
OS 0211 / NRRL Y-12639) (Saccharomyces dairenensis).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Naumovozyma.
OX NCBI_TaxID=1071378 {ECO:0000313|EMBL:CCD26595.1, ECO:0000313|Proteomes:UP000000689};
RN [1] {ECO:0000313|EMBL:CCD26595.1, ECO:0000313|Proteomes:UP000000689}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 10597 / BCRC 20456 / CBS 421 / NBRC 0211 / NRRL Y-12639
RC {ECO:0000313|Proteomes:UP000000689};
RX PubMed=22123960; DOI=10.1073/pnas.1112808108;
RA Gordon J.L., Armisen D., Proux-Wera E., OhEigeartaigh S.S., Byrne K.P.,
RA Wolfe K.H.;
RT "Evolutionary erosion of yeast sex chromosomes by mating-type switching
RT accidents.";
RL Proc. Natl. Acad. Sci. U.S.A. 108:20024-20029(2011).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family. MSH3
CC subfamily. {ECO:0000256|ARBA:ARBA00007094}.
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DR EMBL; HE580275; CCD26595.1; -; Genomic_DNA.
DR RefSeq; XP_003671838.1; XM_003671790.1.
DR AlphaFoldDB; G0WFN4; -.
DR STRING; 1071378.G0WFN4; -.
DR GeneID; 11496153; -.
DR KEGG; ndi:NDAI_0I00260; -.
DR eggNOG; KOG0218; Eukaryota.
DR HOGENOM; CLU_002472_0_2_1; -.
DR OMA; HIAPCEL; -.
DR OrthoDB; 168255at2759; -.
DR Proteomes; UP000000689; Chromosome 9.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF122; DNA MISMATCH REPAIR PROTEIN MSH3; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000000689}.
FT DOMAIN 898..914
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 113..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 117..167
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1056 AA; 121102 MW; 866473093153B923 CRC64;
MASQPTISKF FAKASSPVKN ATAAKKGDTT KEVITHTNNN SGFSSSTADH SQEQVSIIID
SDSESDNEIN LTSVYKTTTD AIDESEVVEI EMLQHNAEKH TEEATVDNLA SEAVTDSNHE
KNPKSAKKSI GVDTKRQEKS KTIKRKNDAT SPERIPKKPK NQDKLTPLDQ QVKELKLKNK
DKILIIRVGY KYKCFAEDAV IVSNILHIKL VPGKLTIRNS NPHDDQYKQF AYCSFPDTRL
NVHLERLIFN NLKVAVVEQT ETIAIKKNDP TANKTQVFQR EIKNTFSKAT FGINDQFAKK
DKRILGDTKS IWGLDFKIDE RENSIQYYII SANLNNGEII YNTFTDELKA LENLKLRIKH
LEPIEIISPK KLPNHILSLF KPSRCLVSYT DNEHHCDNER KTTLNEIGEM LDFAKELKDL
LVHFFIYLKQ YGNEKLLLIR SNYKPFSIDK CITLSHSTIE SLDIITENNG KGSLMWLLDH
TRTSFGLQKL REWILHPSTD SLIIEERLDA IECIIGEVNT IFFESFNQIL KTTPNLLRTL
NRIAYGTTSR KEIYYFLKNM CAINELFINH SNYLDKQVYE SDGNIASKST LLTKIITDIS
EFSKQEQIPD LLAMINISAV MEKNMEKQVI GFFNLNNYDH ASEILRIQQD IESVKYKLND
ELKKIRKLLK RPYLDYKDEI NYFIEVKNTD VKNIPDSWIK MNNTLRVSRF NTPETKQLVE
KLQYHKDLLV QECEKQYTVF ICRLTNEYSI LKNVIDNIAT YDCILSLSAV SCNMGYTRPK
FTDKKRFIKA KNSRNPIIES LNINYVSNDI SMNEEDGIVH IISGPNMGGK SSYIRQVALL
VILAQIGSYV PADYMEMSIF DQVLTRIGAH DNILRGDSTF KVEMLEVLEI VKKSTDNSLL
LLDEVGRGTG TQDGKAISYS LLEYFLHDSS CPLILFTTHF PEMGDITSKF LKCYHMDYVE
ENRPGEKWPS VIFLYKLKPG FTNNSYGLNV AKLANIDTDI INAAYELSEN SKKESENSKF
LYLPTCFRRI LGNNQNSNKD KFVELLSLID EENILD
//
