ID G0XS48_PRODI Unreviewed; 473 AA.
AC G0XS48;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=squalene monooxygenase {ECO:0000256|ARBA:ARBA00012312};
DE EC=1.14.14.17 {ECO:0000256|ARBA:ARBA00012312};
GN Name=terF {ECO:0000313|EMBL:AEH57216.1};
OS Prochloron didemni P2-Fiji.
OC Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales; Prochloraceae;
OC Prochloron.
OX NCBI_TaxID=910454 {ECO:0000313|EMBL:AEH57216.1};
RN [1] {ECO:0000313|EMBL:AEH57216.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=21445351; DOI=10.1371/journal.pone.0017897;
RA Donia M.S., Fricke W.F., Ravel J., Schmidt E.W.;
RT "Variation in tropical reef symbiont metagenomes defined by secondary
RT metabolism.";
RL PLoS ONE 6:E17897-E17897(2011).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SIMILARITY: Belongs to the squalene monooxygenase family.
CC {ECO:0000256|ARBA:ARBA00008802}.
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DR EMBL; HQ407368; AEH57216.1; -; Genomic_DNA.
DR AlphaFoldDB; G0XS48; -.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0004506; F:squalene monooxygenase activity; IEA:UniProtKB-EC.
DR GO; GO:0016126; P:sterol biosynthetic process; IEA:InterPro.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR006076; FAD-dep_OxRdtase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR013698; Squalene_epoxidase.
DR InterPro; IPR040125; Squalene_monox.
DR PANTHER; PTHR10835; SQUALENE MONOOXYGENASE; 1.
DR PANTHER; PTHR10835:SF0; SQUALENE MONOOXYGENASE; 1.
DR Pfam; PF01266; DAO; 1.
DR Pfam; PF08491; SE; 1.
DR PRINTS; PR00420; RNGMNOXGNASE.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 22..67
FT /note="FAD dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF01266"
FT DOMAIN 168..420
FT /note="Squalene epoxidase"
FT /evidence="ECO:0000259|Pfam:PF08491"
SQ SEQUENCE 473 AA; 53094 MW; DA692E7D7816ED3E CRC64;
MGDSQSLIVV IDLMMNSTYH TDIAIVGAGP MGCATALTFA KKGENVVVLE ANPNNSKKLG
GEWIHPLGVQ ILEQLGFDSI RSVASKYSNG KGFVIFPDDG TTPIKLFYPQ NQSGLSCEHR
LLVKILRERA LSHPNVMFIP FARVIEINKQ CLTINMYNDR NIKVSAKRII GADGRASMVR
KALNNSKIYC NQSGTSKKVI SYMAGICISD VELPFEGFGH LILGGPGPIT IYRIGSNQVR
ILLDVPVHKF KELKEKTTYL RYAYSPFIPK VLLSSFEKSL STQTVVWSAN QTSSGSIYGN
DNLTLVGDAA GFHHPLTATG MTLGFKDVEC LGRSENFKTF KRERITNTIV PGLLASLLYG
VFAQKDKGAL SIRQSIYKMW RNNPTDCHQT MLLLSGSQTR IIPFARSFLR VIWIAIIQTL
NFTFAKGDWI YLLETFGSLI VWVRLFFKLC FSRITFHKVE SFYLYWKFLK HHQ
//
