ID G0YYJ5_SIV Unreviewed; 726 AA.
AC G0YYJ5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Envelope glycoprotein gp160 {ECO:0000256|ARBA:ARBA00015406};
DE AltName: Full=Env polyprotein {ECO:0000256|ARBA:ARBA00029888};
DE Flags: Fragment;
GN Name=env {ECO:0000313|EMBL:AEM17284.1};
OS Simian immunodeficiency virus (SIV).
OC Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX NCBI_TaxID=11723 {ECO:0000313|EMBL:AEM17284.1};
OH NCBI_TaxID=9527; Cercopithecidae (Old World monkeys).
OH NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN [1] {ECO:0000313|EMBL:AEM17284.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=28847_15 {ECO:0000313|EMBL:AEM17284.1};
RA Stone M., Keele B.F., Wang Y., Dutra J., Miller C.J.;
RT "Multiple SIVenv variants are transmitted after vaginal SIVmac251
RT inoculation of rhesus macaques with experimentally induced genital
RT inflammation.";
RL Submitted (JAN-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004202};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004202}. Cell
CC membrane {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004251}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004530}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004530}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004505}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004505}. Host cell membrane
CC {ECO:0000256|ARBA:ARBA00004402}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004402}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004433}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004433}. Host endosome membrane
CC {ECO:0000256|ARBA:ARBA00004578}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004578}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004650}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004650}. Virion membrane
CC {ECO:0000256|ARBA:ARBA00004563}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004563}.
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DR EMBL; HQ845669; AEM17284.1; -; Genomic_DNA.
DR GO; GO:0044175; C:host cell endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0020002; C:host cell plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR GO; GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR CDD; cd09909; HIV-1-like_HR1-HR2; 1.
DR Gene3D; 1.10.287.210; -; 1.
DR Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 2.
DR InterPro; IPR036377; Gp120_core_sf.
DR InterPro; IPR000328; GP41-like.
DR InterPro; IPR000777; HIV1_Gp120.
DR Pfam; PF00516; GP120; 1.
DR Pfam; PF00517; GP41; 1.
DR SUPFAM; SSF56502; gp120 core; 1.
DR SUPFAM; SSF58069; Virus ectodomain; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Host cell membrane {ECO:0000256|ARBA:ARBA00022511};
KW Host endosome {ECO:0000256|ARBA:ARBA00023046};
KW Host membrane {ECO:0000256|ARBA:ARBA00022870};
KW Host-virus interaction {ECO:0000256|ARBA:ARBA00022581};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Viral envelope protein {ECO:0000313|EMBL:AEM17284.1};
KW Virion {ECO:0000313|EMBL:AEM17284.1}.
FT TRANSMEM 460..481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 623..644
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..458
FT /note="Human immunodeficiency virus 1 envelope glycoprotein
FT Gp120"
FT /evidence="ECO:0000259|Pfam:PF00516"
FT DOMAIN 476..671
FT /note="Retroviral envelope protein GP41-like"
FT /evidence="ECO:0000259|Pfam:PF00517"
FT REGION 659..692
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 570..597
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 659..674
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AEM17284.1"
FT NON_TER 726
FT /evidence="ECO:0000313|EMBL:AEM17284.1"
SQ SEQUENCE 726 AA; 83623 MW; B3900EC4E58BA709 CRC64;
ESFDAWENTV TEQAIEDVWQ LFETSIKPCV KLSPLCITMR CNKSETDKWG LTKSSTTTTA
TPASTTRTTS AKIDMVNETS SCITHNNCTG LEQEQMISCK FNMTGLKRDK KKEYNETWYS
TDLVCEQGNS TDNESRCYMN HCNTSVIQES CDKHYWDTIR FRYCAPPGYA LLRCNDTNYS
GFMPKCSKVV VSSCTRMMET QTSTWFGFNG TRAENRTYIY WHGRDNRTII SLNKYYNLTM
KCRRPGNKTV LPVTIMSGLV FHSQPINDRP KQAWCWFGGN WKDAIKEVKQ TIVKHPRYTG
TNNTDKINLT APRGGDPEVT FMWTNCRGEF LYCKMNWFLN WVEDRNLTLT TQKLRERHKR
NYVPCHIRQI INTWHKVGKN VYLPPREGDL TCNSTVTSLI ANIDWTDGNQ TNITMSAEVA
ELYRLELGDY KLVEITPIGL APTDVKRYTT GGTSRNKRGV FVLGFLGFLA TAGSAMGAAS
LTLTAQSRTL LAGIVQQQQQ LLDVVKRQQE LLRLTVWGTK NLQTRVTAIE KYLKDQAQLN
AWGCAFRQVC HTTVPWPNAS LTPDWNNDTW QEWERKVDFL EENITALLEE AQIQQEKNMY
ELQKLNSWDV FGNWFDLASW IRYIQYGIYI VVGVILLRIV IYIVQMLAKL RQGYRPVFSS
PPSYSQQIHT QQDPALPTRE GKEGDGGEGG GNSSWPWQIE YIHFLIRQLI RLLTWLFSNC
RTLLSR
//
