ID G0Z0S0_HHV1 Unreviewed; 376 AA.
AC G0Z0S0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Thymidine kinase {ECO:0000313|EMBL:AEL30068.1};
GN Name=UL23 {ECO:0000313|EMBL:AEL30068.1};
OS Human herpesvirus 1 (HHV-1) (Human herpes simplex virus 1).
OC Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes;
OC Herpesvirales; Orthoherpesviridae; Alphaherpesvirinae; Simplexvirus;
OC Simplexvirus humanalpha1.
OX NCBI_TaxID=10298 {ECO:0000313|EMBL:AEL30068.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:AEL30068.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=TG2 {ECO:0000313|EMBL:AEL30068.1};
RX PubMed=22457282; DOI=10.1093/infdis/jis237;
RA van Velzen M., van Loenen F.B., Meesters R.J., de Graaf M., Remeijer L.,
RA Luider T.M., Osterhaus A.D., Verjans G.M.;
RT "Latent acyclovir-resistant herpes simplex virus type 1 in trigeminal
RT ganglia of immunocompetent individuals.";
RL J. Infect. Dis. 205:1539-1543(2012).
RN [2] {ECO:0000313|EMBL:QCY51819.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=S4.48 {ECO:0000313|EMBL:QCY51819.1}, and S4.51
RC {ECO:0000313|EMBL:QCY51821.1};
RX PubMed=31152759; DOI=.1016/j.antiviral.2019.05.012;
RA Labrunie T., Ducastelle S., Domenech C., Ader F., Morfin F., Frobert E.;
RT "UL23, UL30, and UL5 characterization of HSV1 clinical strains isolated
RT from hematology department patients.";
RL Antiviral Res. 168:114-120(2019).
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DR EMBL; HQ685975; AEL30068.1; -; Genomic_DNA.
DR EMBL; MK896162; QCY51819.1; -; Genomic_DNA.
DR EMBL; MK896164; QCY51821.1; -; Genomic_DNA.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004797; F:thymidine kinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0071897; P:DNA biosynthetic process; IEA:UniProtKB-UniRule.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0006230; P:TMP biosynthetic process; IEA:UniProtKB-UniRule.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_04029; HSV_KITH; 1.
DR InterPro; IPR001889; Herpes_TK.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00693; Herpes_TK; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AEL30068.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:AEL30068.1}.
FT REGION 1..39
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 260..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 376 AA; 40925 MW; 86A170332F9ABC5C CRC64;
MASYPCHQHA SAFDQAARSR GHSNRRTALR PRRQQEATEV RLEQKMPTLL RVYIDGPHGM
GKTTTTQLLV ALGSRDDIVY VPEPMTYWQV LGASETIANI YTTQHRLDQG EISAGDAVVV
MTSAQITMGM PYAVTDAVLA PHIGGEAGSS HAPPPALTLI FDRHPIAALL CYPAARYLMG
SMTPQAVLAF VALIPPTLPG TNIVLGALPE DRHIDRLAKR QRPGERLDLA MLAAIRRVYG
LLANTVRYLQ GGGSWREDWG QLSGTAVPPQ GAEPQSNAGP RPHIGDTLFT LFRAPELLAP
NGDLYNVFAW ALDVLAKRLR PMHVFILDYD QSPAGCRDAL LQLTSGMVQT HVTTPGSIPT
ICDLARTFAR EMGEAN
//
