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Database: UniProt
Entry: G1C8B8_HBV
LinkDB: G1C8B8_HBV
Original site: G1C8B8_HBV 
ID   G1C8B8_HBV              Unreviewed;        90 AA.
AC   G1C8B8;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   22-FEB-2023, entry version 40.
DE   RecName: Full=External core antigen {ECO:0000256|RuleBase:RU361253};
GN   Name=C {ECO:0000256|RuleBase:RU361253};
OS   Hepatitis B virus (HBV).
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Blubervirales; Hepadnaviridae; Orthohepadnavirus.
OX   NCBI_TaxID=10407 {ECO:0000313|EMBL:AEK93556.1, ECO:0000313|Proteomes:UP000114185};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9598; Pan troglodytes (Chimpanzee).
RN   [1] {ECO:0000313|EMBL:AEK93556.1, ECO:0000313|Proteomes:UP000114185}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TK57 {ECO:0000313|EMBL:AEK93556.1};
RX   PubMed=21678435; DOI=10.1002/jmv.22118;
RA   Cox L.E., Arslan O., Allain J.P.;
RT   "Characterization of hepatitis B virus in Turkish blood donors, and the
RT   prevalence of the SP1 splice variant.";
RL   J. Med. Virol. 83:1321-1325(2011).
CC   -!- FUNCTION: May regulate immune response to the intracellular capsid in
CC       acting as a T-cell tolerogen, by having an immunoregulatory effect
CC       which prevents destruction of infected cells by cytotoxic T-cells.
CC       {ECO:0000256|RuleBase:RU361253}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU361253}.
CC   -!- PTM: Cleaved by host furin. {ECO:0000256|RuleBase:RU361253}.
CC   -!- PTM: Phosphorylated. {ECO:0000256|RuleBase:RU361253}.
CC   -!- SIMILARITY: Belongs to the orthohepadnavirus precore antigen family.
CC       {ECO:0000256|RuleBase:RU361253}.
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DR   EMBL; JF754589; AEK93556.1; -; Genomic_DNA.
DR   Proteomes; UP000114185; Genome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR   GO; GO:0019049; P:mitigation of host antiviral defense response; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.4090.10; Viral capsid, core domain supefamily, Hepatitis B virus; 1.
DR   InterPro; IPR013195; Hepatitis_B_virus_capsid_N.
DR   InterPro; IPR002006; Hepatitis_core.
DR   InterPro; IPR036459; Viral_capsid_core_dom_sf_HBV.
DR   Pfam; PF08290; Hep_core_N; 1.
DR   Pfam; PF00906; Hepatitis_core; 1.
DR   SUPFAM; SSF47852; Hepatitis B viral capsid (hbcag); 1.
PE   3: Inferred from homology;
KW   Host-virus interaction {ECO:0000256|RuleBase:RU361253};
KW   Viral immunoevasion {ECO:0000256|RuleBase:RU361253}.
FT   DOMAIN          1..27
FT                   /note="Hepatitis B virus capsid N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08290"
SQ   SEQUENCE   90 AA;  9952 MW;  CA43BF4BC816958F CRC64;
     MQLFHLCLII FCSCPTVQAS KLCLGWLWGM DIDPYKEFGA TVELLSFLPS DFFPSVRDLL
     DTASAHLTIL HSGKQFFAGG TNDSSHLGGW
//
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