ID G1K3E7_XENTR Unreviewed; 502 AA.
AC G1K3E7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 02-DEC-2020, sequence version 3.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Cyclin-L2 {ECO:0000313|Ensembl:ENSXETP00000024290};
GN Name=ccnl2 {ECO:0000313|Ensembl:ENSXETP00000024290};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364 {ECO:0000313|Ensembl:ENSXETP00000024290};
RN [1] {ECO:0000313|Ensembl:ENSXETP00000024290}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Nigerian {ECO:0000313|Ensembl:ENSXETP00000024290};
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [2] {ECO:0000313|Ensembl:ENSXETP00000024290}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (AUG-2011) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus speckle {ECO:0000256|ARBA:ARBA00004324}.
CC Nucleus, nucleoplasm {ECO:0000256|ARBA:ARBA00004642}.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin L subfamily.
CC {ECO:0000256|ARBA:ARBA00010589}.
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DR AlphaFoldDB; G1K3E7; -.
DR Ensembl; ENSXETT00000024290; ENSXETP00000024290; ENSXETG00000017379.
DR AGR; Xenbase:XB-GENE-956522; -.
DR Xenbase; XB-GENE-956522; ccnl2.
DR HOGENOM; CLU_022000_6_1_1; -.
DR InParanoid; G1K3E7; -.
DR TreeFam; TF101011; -.
DR Bgee; ENSXETG00000017379; Expressed in ovary and 25 other cell types or tissues.
DR GO; GO:0016607; C:nuclear speck; IEA:UniProtKB-SubCell.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd20593; CYCLIN_CCNL2_rpt2; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR043198; Cyclin/Ssn8.
DR InterPro; IPR004367; Cyclin_C-dom.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10026; CYCLIN; 1.
DR PANTHER; PTHR10026:SF45; CYCLIN-L2; 1.
DR Pfam; PF02984; Cyclin_C; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR PIRSF; PIRSF036580; Cyclin_L; 1.
DR SMART; SM00385; CYCLIN; 2.
DR SMART; SM01332; Cyclin_C; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
PE 3: Inferred from homology;
KW Cyclin {ECO:0000256|ARBA:ARBA00023127, ECO:0000256|RuleBase:RU000383};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 66..168
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT DOMAIN 177..290
FT /note="Cyclin C-terminal"
FT /evidence="ECO:0000259|SMART:SM01332"
FT DOMAIN 181..265
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT REGION 298..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 349..363
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..404
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 418..433
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..493
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 502 AA; 57494 MW; 6A75187EAAEEBD1E CRC64;
MEEKKMAANS SAVSSDGILI GDKLYSGVMI SLENCLMAEE RCALTPSVVD GIDVNTEIDL
RCVGCELVQA AGILLRLPQV AMATGQVLFQ RFFYTKSFVK HSMEHVAMAC VHLASKIEEA
PRRIRDVINV FHRLRQLREK QKSTPLILDQ EYVNLKNQII KAERRVLKEL GFCVHVKHPH
KIIVMYLQVL ECERNKHLVQ TSWNYMNDSL RTDVFVRFNP ETIACACIFL AARTLEIPLP
NRPHWFYLFG ASEEDIKEIC LQILRLYTRK KADVALLENK VEKRKLFIEE AKAKAKGLLP
DGTPRLENAP EFSPSLKNDS PKELKANKPS PLAVHALKNC KRKVDGTKRP TSSSPVNGRV
SKGRDSRSGS RSRDQSYSRS QSRSQSPKRR KSQSYSPSSD SKSRSPSRSR SDSPPHKPNH
GSYKSTKGHV YGNNSDYKYQ GHKRRSRSRS SSPSHSRSRE SSDSGKYKKK DHYYRRERSR
SYDRVSHRGY DREYHGHSHH RR
//
