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Database: UniProt
Entry: G1K8C2_ANOCA
LinkDB: G1K8C2_ANOCA
Original site: G1K8C2_ANOCA 
ID   G1K8C2_ANOCA            Unreviewed;      2415 AA.
AC   G1K8C2;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 2.
DT   25-OCT-2017, entry version 48.
DE   RecName: Full=Voltage-dependent R-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1E {ECO:0000313|Ensembl:ENSACAP00000000147};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000000147, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000000147, ECO:0000313|Proteomes:UP000001646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000000147};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACAP00000000147}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1E
CC       gives rise to R-type calcium currents. R-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA).
CC       They are however insensitive to dihydropyridines (DHP), omega-
CC       conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega-
CC       Aga-IVA). Calcium channels containing alpha-1E subunit could be
CC       involved in the modulation of firing patterns of neurons which is
CC       important for information processing.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSACAP00000000147}.
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DR   STRING; 28377.ENSACAP00000000147; -.
DR   Ensembl; ENSACAT00000000150; ENSACAP00000000147; ENSACAG00000000106.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   InParanoid; G1K8C2; -.
DR   OrthoDB; EOG091G0TKO; -.
DR   TreeFam; TF312805; -.
DR   Proteomes; UP000001646; Chromosome 4.
DR   Bgee; ENSACAG00000000106; -.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0008331; F:high voltage-gated calcium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005449; VDCC_R_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF57; PTHR10037:SF57; 1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01633; RVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001646};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    280    301       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    313    333       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    372    391       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    446    467       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    479    501       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    627    647       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    653    671       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    753    775       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    831    853       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1259   1278       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1331   1348       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1392   1414       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1504   1529       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1585   1603       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1615   1638       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1644   1662       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1709   1727       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1802   1826       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1842   1877       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      849    876       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2415 AA;  273676 MW;  BE62DA97623C2D88 CRC64;
     MMLSLSTCSI STHMLSEVGF PVDGAPELEN DPQRCVLALP EEEAWRKHRL GPMQSTQSCN
     LLDPETLSDA LVSRTASFDA LYELRSQDME SSLGLDGSST FDVGQSQLLP VSPEVIKRRR
     GGLIEQRDIV KAHEAHKIQS TPQARRKEWE MARFGEAMAG RVGSGDGATE QNRNRQGAPA
     PPGGTPVQAY KQTKAQRART MALYNPIPVR QNCFTVNRSL FIFGEDNIVR KYAKKLIDWP
     PFEYMILATI IANCIVLALE QHLPEDDKTP MSRRLEKTEP YFIGIFCFEA GIKIVALGFV
     FHKGSYLRNG WNVMDFIVVL SGILATAGTH FNTHVDLRTL RAVRVLRPLK LVSGIPSLQI
     VLKSIMKAMV PLLQIGLLLF FAILMFAIIG LEFYSGKLHR ACYVNNSGEL QELDPPHPCG
     VQGCPAGYEC RDWIGPNDGI TQFDNILFAV LTVFQCITME GWTTVLYNTN DALGATWNWL
     YFIPLIIIGS FFVLNLVLGV LSGEFAKERE RVENRRAFMK LRRQQQIERE LNGYRAWIDK
     AEEVMLAEEN KNSGTSALEV LRRATIKRNR TEVMNRDSSD ERVDISSVGT PLARASIKSA
     KLDGANYFRH KERLLRISVR HMVKSQVFYW LVLSIVALNT ACVAIVHHNQ PPWLTHLLYY
     AEFIFLGLFL LEMSLKMYGM GPRLYFHSSF NCFDCGVTVG SIFEVVWAIF RPGTSFGISV
     MRALRLLRIF KVTKYWASLR NLVVSLMSSM KSIISLLFLL FLFIVVFALL GMQLFGGRFN
     FMDGTPSANF DTFPAAIMTV FQILTGEDWN EVMYNGIRSQ GGVSSGMWSS IYFIVLTLFG
     NYTLLNVFLA IAVDNLANAQ ELTKDEQEEE EAFNQKHALQ KAKEVSPMSA PNMPAIERER
     RRRHHMSVWE QRTSQLRRHM QMSSQEGINN EDPPLLNPHA SIFRRRKLLE NSGPEKNEEG
     QGDRSERANG EGQDQQIPGS NPCPSIQENQ KSPSSRPKKE WEEWHHKSFH GNCDLIEPEG
     GGSGGFEERA RLRQSQRRSR HRRVRTEAKE HRAASQEMAP EEAVPAEGEQ NVEQKKNEEE
     KEALIEKDQG TGEEQKITNE VSVNDAAFHV ATHETSPSEG HLDLNQSKDV SPVEQDGNSP
     DTSEQALLGD LPMESGRTIS RSEPDLSSIT TNVEKATESA TIMIDVQDSA VVQISNKTDG
     EASPLKEPET KEEEEVEVEK KKPKKKKSAT GKPMVPHSSM FIFSTTNPIR RACHYIVNLR
     YFEMCILLVI AASSIALAAE DPVLTNSERN KVLRYFDYVF TGVFTFEMVI KMIDQGLILQ
     DGSYFRDLWN ILDFIVVVGA LMAFALATNK GRDIKTIKSL RVLRVLRPLK TIKRLPKLKA
     VFDCVVTSLK NVFNILIVYK LFMFIFAVIA VQLFKGKFFY CTDSSKDTQK DCIGNYVDHE
     KNLMEVKCRQ WKRHEFHYDN IIWALLTLFT VSTGEGWPQV LQHSVDVTEE DRGPSRSNRM
     EMSIFYVVYF VVFPFFFVNI FVALIIITFQ EQGDKMMEEC SLEKNERACI DFAISAKPLT
     RYMPQNRHTF QYRVWHFVVS PSFEYTIMAM IALNTIVLMM KYYSAPYTYE LALKYLNIAF
     TMVFSLECVL KIIAFGFLNY FRDTWNIFDF ITVIGSITEI ILTDSKLVNT SSFNMSFLKL
     FRAARLIKLL RQGYTIRILL WTFVQSFKAL PYVCLLIAML FFIYAIIGMQ VFGNIKLDEE
     SHINRHNNFR SFLGSLMLLF RSATGEAWQE IMLSCLGGKG CESDTTATSG QNGSEQCGTD
     LAYVYFVSFI FFCSFLMLNL FVAVIMDNFE YLTRDSSILG PHHLDEFVRI WAEYDRAACG
     RIHYTEMYEM LTLMSPPLGL GKRCPSKVAY KRLVLMNMPV AEDNTVHFTS TLMALIRTAL
     DIKIAKGGAE WQQLDSELQK EILTIWPHLS QKQLDVLVPM PKTTDLTVGK IYAAMMIMDY
     YKQSKAKKQR QQLEEQKNAP MFQRMEPSSL PQEIISNAKA LPYLQQETFS GLSSRSGFPS
     LSPLSPQEIF QLACMDPTHG EYQEQQSLEP EVREFKRVQP SNCGSYLPVD TQERAVSGRA
     SSMPRLTVDP QVVTDPGSMR RSFSTIRDKR TNTSWLDEFS MEKSSENTYK SRRRSYHSAL
     YLSSRRLNTD SGHRSDTHRS GGRERGRSKE RKHLLSPDIS RCNSEERSPQ ADGDSPERRQ
     SRSPSEGRSQ TPNRQGTGSL SESSIPSISD TSTPRRSRRQ LPPVPPKPRP LISYAAMMQH
     CGDTSPNPDD SEGGSPLLSG TLETNNPCLT ESSSSPTGKQ SLLSTPQHYI SEPYLMLQDD
     SHASDCGEEE TLTFEAAVAT SLGRSNTIAS GPRSRHSWQM PNGHYRRRRR GASSQGVMFG
     AGIDVLSDTE EDDKC
//
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