ID G1KAR5_ANOCA Unreviewed; 358 AA.
AC G1KAR5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=Zinc transporter ZIP13 {ECO:0000256|ARBA:ARBA00040592};
DE AltName: Full=Solute carrier family 39 member 13 {ECO:0000256|ARBA:ARBA00042542};
DE AltName: Full=Zrt- and Irt-like protein 13 {ECO:0000256|ARBA:ARBA00042972};
GN Name=SLC39A13 {ECO:0000313|Ensembl:ENSACAP00000002368.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000002368.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000002368.3, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000002368.3,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000002368.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351,
CC ChEBI:CHEBI:29105; Evidence={ECO:0000256|ARBA:ARBA00034634};
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004156}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC {ECO:0000256|ARBA:ARBA00006939}.
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DR RefSeq; XP_003214669.1; XM_003214621.3.
DR AlphaFoldDB; G1KAR5; -.
DR STRING; 28377.ENSACAP00000002368; -.
DR Ensembl; ENSACAT00000002429.4; ENSACAP00000002368.3; ENSACAG00000002440.4.
DR GeneID; 100554988; -.
DR KEGG; acs:100554988; -.
DR CTD; 91252; -.
DR eggNOG; KOG2694; Eukaryota.
DR GeneTree; ENSGT00940000157349; -.
DR HOGENOM; CLU_015114_0_2_1; -.
DR InParanoid; G1KAR5; -.
DR OrthoDB; 5488029at2759; -.
DR TreeFam; TF318470; -.
DR Proteomes; UP000001646; Chromosome 1.
DR Bgee; ENSACAG00000002440; Expressed in heart and 12 other cell types or tissues.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0000139; C:Golgi membrane; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0005385; F:zinc ion transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0050873; P:brown fat cell differentiation; IEA:Ensembl.
DR GO; GO:0061448; P:connective tissue development; IEA:Ensembl.
DR GO; GO:0006882; P:intracellular zinc ion homeostasis; IBA:GO_Central.
DR GO; GO:0071577; P:zinc ion transmembrane transport; IBA:GO_Central.
DR InterPro; IPR003689; ZIP.
DR PANTHER; PTHR16950; ZINC TRANSPORTER SLC39A7 HISTIDINE-RICH MEMBRANE PROTEIN KE4; 1.
DR PANTHER; PTHR16950:SF16; ZINC TRANSPORTER ZIP13; 1.
DR Pfam; PF02535; Zip; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..358
FT /note="Zinc transporter ZIP13"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003412688"
FT TRANSMEM 46..68
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 88..105
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 125..143
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 304..324
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 336..355
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 358 AA; 38383 MW; 68132E64B5C25775 CRC64;
MGEGFFIHGV LSILLLTVSC VAHELPLCEK EAESWGAIFS EDRLDAWIYS LIGSVMVGLS
GVFPLLIIPL ETGAALKSEE GSRRLKQLLS FAIGGLLGNV FLHLLPEAWA YTCSATAGEG
QSFQQQKLLG LWVIVGLLTF LSLQKMFPDS EKQGESSLVN DPQVSAKKIP NGSSFSVQEA
ANPIQRKKPG RAQCNGSSRV SLSSTPKIKI SGYLNLLANT IDNFTHGLAV AASFLVSRKV
GLLTTMAILL HEIPHEVGDF AILLRAGFDR WSAAKLQLST ALGGVLGACF AICAQSPKGT
GETIAWILPF TSGGFLYIAL VNVVPDLLEE KNPWNSVQQV LLLCTGILVM VLLSLTTE
//
