ID G1KCJ9_ANOCA Unreviewed; 478 AA.
AC G1KCJ9;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Suppressor of fused homolog {ECO:0000256|PIRNR:PIRNR011844};
GN Name=SUFU {ECO:0000313|Ensembl:ENSACAP00000004038.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000004038.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000004038.3, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000004038.3,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000004038.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR011844}.
CC Nucleus {ECO:0000256|PIRNR:PIRNR011844}.
CC -!- SIMILARITY: Belongs to the SUFU family.
CC {ECO:0000256|PIRNR:PIRNR011844}.
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DR RefSeq; XP_003218526.1; XM_003218478.3.
DR AlphaFoldDB; G1KCJ9; -.
DR STRING; 28377.ENSACAP00000004038; -.
DR Ensembl; ENSACAT00000004131.4; ENSACAP00000004038.3; ENSACAG00000004102.4.
DR GeneID; 100552650; -.
DR KEGG; acs:100552650; -.
DR CTD; 51684; -.
DR eggNOG; ENOG502QT57; Eukaryota.
DR GeneTree; ENSGT00390000009747; -.
DR HOGENOM; CLU_033906_0_0_1; -.
DR InParanoid; G1KCJ9; -.
DR OrthoDB; 5385318at2759; -.
DR TreeFam; TF324548; -.
DR Proteomes; UP000001646; Chromosome 3.
DR Bgee; ENSACAG00000004102; Expressed in embryonic post-anal tail and 13 other cell types or tissues.
DR GO; GO:0005929; C:cilium; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:1990788; C:GLI-SUFU complex; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0008013; F:beta-catenin binding; IEA:Ensembl.
DR GO; GO:0019901; F:protein kinase binding; IEA:Ensembl.
DR GO; GO:0035904; P:aorta development; IEA:Ensembl.
DR GO; GO:0060976; P:coronary vasculature development; IEA:Ensembl.
DR GO; GO:0001947; P:heart looping; IEA:Ensembl.
DR GO; GO:0045879; P:negative regulation of smoothened signaling pathway; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:2000059; P:negative regulation of ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR GO; GO:0001843; P:neural tube closure; IEA:Ensembl.
DR GO; GO:0043588; P:skin development; IEA:Ensembl.
DR GO; GO:0021776; P:smoothened signaling pathway involved in spinal cord motor neuron cell fate specification; IEA:Ensembl.
DR GO; GO:0021775; P:smoothened signaling pathway involved in ventral spinal cord interneuron specification; IEA:Ensembl.
DR GO; GO:0003281; P:ventricular septum development; IEA:Ensembl.
DR Gene3D; 3.30.1360.230; Sufu, C-terminal domain; 1.
DR InterPro; IPR020941; SUFU-like_domain.
DR InterPro; IPR024314; SUFU_C.
DR InterPro; IPR038489; SUFU_C_sf.
DR InterPro; IPR037181; SUFU_N.
DR InterPro; IPR007768; Suppressor_of_fused.
DR InterPro; IPR016591; Suppressor_of_fused_euk.
DR PANTHER; PTHR10928; SUPPRESSOR OF FUSED; 1.
DR PANTHER; PTHR10928:SF2; SUPPRESSOR OF FUSED HOMOLOG; 1.
DR Pfam; PF05076; SUFU; 1.
DR Pfam; PF12470; SUFU_C; 1.
DR PIRSF; PIRSF011844; Suppressor_of_fused_protein; 1.
DR SUPFAM; SSF103359; Suppressor of Fused, N-terminal domain; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR011844};
KW Nucleus {ECO:0000256|PIRNR:PIRNR011844};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT DOMAIN 57..233
FT /note="Suppressor of fused-like"
FT /evidence="ECO:0000259|Pfam:PF05076"
FT DOMAIN 248..467
FT /note="Suppressor of fused C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12470"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 313..344
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 317..334
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 478 AA; 53432 MW; E51A4CBD64489481 CRC64;
METSSSAASA ASGPTPGPFP PLFPPGLHGI YGECRRLYPE QPNPLQVTAI LKYWLGGPDP
LDYVSMYRSL GSPTENVPEH WHYVSFGLSD LYGDNRVHEF TGPDGPSGFG FELTFRLKRE
TGESAPPTWP AELMQGLARY VFQSENTFCS GDHVSWHSPL DNSESRIQHM LLTEDPQMQP
VQTPFGVVTF LQIVGVCTEE LHAAQQWNGQ GILELLRTVP VAGGPWLITD MRRGETIFEI
DPHLQQDRVD KGIETDGSNL SGVSAKCAWD DLSRPPEDDE DSRSICIGSH PRRLSGKDTE
QIRETLRRGL EINSKPILPP INTQRQNGLN NDRAPSRKDS LESESSAAII PHELIRTRQL
ESVHLKFNQE SGALIPLCLR GRLLHGRHFT YKSITGDTAI TFVSTGVEGA FATEEHPYAA
HGPWLQILLT EEFVERMLED LEDLNSPEEF KLPKEYSWPE KKLKVSILPD AVFDNPLH
//