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Database: UniProt
Entry: G1KDG6_ANOCA
LinkDB: G1KDG6_ANOCA
Original site: G1KDG6_ANOCA 
ID   G1KDG6_ANOCA            Unreviewed;      2312 AA.
AC   G1KDG6;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   25-OCT-2017, entry version 47.
DE   RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1G {ECO:0000313|Ensembl:ENSACAP00000004908};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000004908, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000004908, ECO:0000313|Proteomes:UP000001646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000004908};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACAP00000004908}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. This channel gives
CC       rise to T-type calcium currents. T-type calcium channels belong to
CC       the "low-voltage activated (LVA)" group and are strongly blocked
CC       by nickel and mibefradil. A particularity of this type of channels
CC       is an opening at quite negative potentials, and a voltage-
CC       dependent inactivation. T-type channels serve pacemaking functions
CC       in both central neurons and cardiac nodal cells and support
CC       calcium signaling in secretory cells and vascular smooth muscle.
CC       They may also be involved in the modulation of firing patterns of
CC       neurons which is important for information processing as well as
CC       in cell growth processes. {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSACAP00000004908}.
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DR   STRING; 28377.ENSACAP00000004908; -.
DR   Ensembl; ENSACAT00000005020; ENSACAP00000004908; ENSACAG00000004254.
DR   eggNOG; KOG2302; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; G1KDG6; -.
DR   OMA; FWRLICD; -.
DR   OrthoDB; EOG091G02L1; -.
DR   TreeFam; TF313555; -.
DR   Proteomes; UP000001646; Chromosome 2.
DR   Bgee; ENSACAG00000004254; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:Ensembl.
DR   GO; GO:0008332; F:low voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0097110; F:scaffold protein binding; IEA:Ensembl.
DR   GO; GO:0086056; F:voltage-gated calcium channel activity involved in AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0086059; F:voltage-gated calcium channel activity involved SA node cell action potential; IEA:Ensembl.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0070509; P:calcium ion import; IEA:Ensembl.
DR   GO; GO:0086002; P:cardiac muscle cell action potential involved in contraction; IEA:Ensembl.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:Ensembl.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   GO; GO:0045956; P:positive regulation of calcium ion-dependent exocytosis; IBA:GO_Central.
DR   GO; GO:0060371; P:regulation of atrial cardiac muscle cell membrane depolarization; IEA:Ensembl.
DR   GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
DR   GO; GO:0010045; P:response to nickel cation; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005445; VDCC_T_a1.
DR   InterPro; IPR030154; VDCC_T_a1G.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF137; PTHR10037:SF137; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01629; TVDCCALPHA1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001646};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   SIGNAL        1     18       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        19   2312       Voltage-dependent T-type calcium channel
FT                                subunit alpha. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5003412974.
FT   TRANSMEM     42     62       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    133    156       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    258    279       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    285    310       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    687    708       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    720    738       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    780    799       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    856    879       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1197   1215       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1235   1256       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1332   1354       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1433   1457       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1530   1549       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1561   1582       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1631   1652       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1664   1684       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1748   1769       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        1    321       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      656    887       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1195   1467       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1531   1780       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED     1463   1493       {ECO:0000256|SAM:Coils}.
FT   COILED     1770   1793       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2312 AA;  260972 MW;  A21C2C7E88A2E924 CRC64;
     WFERVSMLVI LLNCVTLGMF HPCEDMGCDS PRCKILQSFD DFIFAFFAVE MIVKMIALGI
     FGKKCYLGDT WNRLDFFIVL AGMLEYSLDL QNVSFSAVRT VRVLRPLRAI NRVPSMRILV
     TLLLDTLPML GNVLLLCFFV FFIFGIVGVQ LWAGLLRNRC FLPENFSFPY MLDLEPYYQT
     ENEDESPFIC SQPRENGMRY CRSIPIRREE GLECTLDYYS YNDTTNTSCV NWNQYYTNCS
     AGEHNPFKGA INFDNIGYAW IAIFQVITLE GWVDIMYFVM DAHSFYNFIY FILLIIVGSF
     FMINLCLVVI ATQFSETKQR ESQLMKEQRI RHHSNASTLA SFSEPGSCYD ELLKYLVYIL
     RKASKQVVEM YRTTGVKMGL LSSPAIRSSA ERQPCKHRPQ KRPSVHHLIH HHHHHHHHYH
     LGNGSLQAPR ASPEISDVDT SSLHNGANRL MIPLTANPHA ASSNAESVHS IYHADCHFEP
     IHCRSSLSQP GLSLPGPELL PRTVVGSKVY PTVHPSTSQE LLKGLGESTL NPGMSTLMSL
     NIPPGPYSSM QKLLETQSTG PYQSSCKISS QCGKSDNICS PESCPYCMKT LANKPEQTDN
     ETGDSDSDGV YEFTQDAHYS DQRDPQRWKT QGKNTLKLLA FWKVVCETFR KIVDSKYFGR
     GIMIAILINT LSMGIEYHEQ PEELTNALEI SNIVFTSLFA LEMLLKLLVY GPFGYIKNPY
     NIFDGIIVVI SLSVWEIVGQ QGGGLSVLRT FRLMRVLKLV RFMPALQRQL VVLMKTMDNV
     ATFCMLLMLF IFIFSILGMH LFGCKFASER DGDTLPDRKN FDSLLWAIVT VFQILTQEDW
     NKVLYNGMAS TSSWAALYFI ALMTFGNYVL FNLLVAILVE GFRQSYEEIT KREAASRQLS
     CIQLPVDSSV GDATKSDSDG ELFPHALEED YRLKKNFSNP ALMALCDHPE LKKNLTPPLI
     IHTAATPMPM PRSAIYGEAA QGYDSRRASS ISMDPNIYDL KSPVSARSSP HSPWSAGSSW
     NSRRSSWNSI GRAPSLKRRN QSGERKSLLS GDGKQSSEEG ESSDEEQSSR TGSINGSIPH
     RMESLETKGS FDFQDTLQVP SLYRTSSIHS SRSSASERQD CNGKTTSRVL IQQLHLEDHL
     PECDDDEGNL SKKDRMKAWI RARLPSWCKE RDSWSVYIFA PQSKFRMICN KIITHKMFDH
     VVLVIIFLNC ITIAMERPKI EPHSAERIFL TLSNYIFTAI FLAEMTIKVV ALGLCFCEKA
     YLRSSWNVLD GVLVLISVVD ILVSMVSDSG TKILGMLRVL RLLRTLRPLR VISRAQGLKL
     VVETLMSSLK PIGNIVVICC AFFIIFGILG VQLFKGKFFV CQGENIRNIT NKSDCADASY
     KWVRHKYNFD NLGQALMSLF VLASKDGWVD IMYDGLDAVG VDQQPIMNYN PWMLLYFISF
     LLIVAFFVLN MFVGVVVENF HKCRQHQEEE EAKRREEKRL KRLEKKRRNL MLDDVIMENS
     ASAVPEAQCK PYYSDYSRFR LLIHQMCTTH YLDLFITGVI GLNVITMAME HYQQPKVLDE
     ALKICNYIFT IIFVLESVFK LIAFGFRRFF QDRWNQLDLA IVLLSIMGIT LEEIEVNASL
     PINPTIIRIM RVLRIARVLK LLKMAVGMRA LLDTVMQALP QVGNLGLLFM LLFFIFAALG
     VELFGDLECD DTHPCEGLGR HATFRNFGMA FLTLFRVSTG DNWNGIMKDT LRDCDEESTC
     YNTVISPIYF VSFVLTAQFV LVNVVIAVLM KHLEESNKEA KEEAELELEL EMEMKTISPG
     QHPLADPFMW PGSNGGERPE SPGGYANPMQ IKMDSQLSLV HPMERHLFDT ISLLIQESLE
     GELKLMDNLS GSVCHHYALP TTDNYNTEKQ IPLAEMEALS LTSDILSENS WSLALTDDSF
     PDDNNTFLLN APESNFEIHQ KTDLLPPSPD KDLLSVRKTS VGRTHSLPND SYMFQAPDTS
     PHNDSSGEKN SSHQKSQSGS TTSVQSQPAN IDALLQIPRD LFQPLKPQYN PDWESKPRVP
     PPVHSPSAER LLRRQMAIRN DSSDTHSSES RENIHAEVSE LSDPNARDSP SWGRSSVRTQ
     QHSCNQYNIS KHVPDLCACT DSLQELSADP LDQEVSEINS SFTSGTCSAM SASSVVQPET
     PKDLKKCYSV DTQGLLKKPS SWLDDQRRHS IEICSMENSP QHHSTSSSSG FISQVLSEME
     GLQGTRPKKK LSPPCISIDP PDEQGLLLRG SRTTSPSSAD VCLRRRAPSW DSKDSMDAGD
     SALPESVSVT PTPKKDLLTL PSFSFDQKDV DP
//
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