ID G1KDH5_ANOCA Unreviewed; 1948 AA.
AC G1KDH5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Minichromosome maintenance complex component 3 associated protein {ECO:0000313|Ensembl:ENSACAP00000004933.3};
GN Name=MCM3AP {ECO:0000313|Ensembl:ENSACAP00000004933.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000004933.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000004933.3, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000004933.3,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000004933.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SAC3 family.
CC {ECO:0000256|ARBA:ARBA00038443}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_008112685.1; XM_008114478.2.
DR RefSeq; XP_008112696.1; XM_008114489.2.
DR STRING; 28377.ENSACAP00000004933; -.
DR Ensembl; ENSACAT00000005046.4; ENSACAP00000004933.3; ENSACAG00000004980.4.
DR GeneID; 100558127; -.
DR KEGG; acs:100558127; -.
DR CTD; 8888; -.
DR eggNOG; KOG1860; Eukaryota.
DR GeneTree; ENSGT00940000156322; -.
DR HOGENOM; CLU_001842_1_0_1; -.
DR InParanoid; G1KDH5; -.
DR OrthoDB; 91913at2759; -.
DR TreeFam; TF105948; -.
DR Proteomes; UP000001646; Chromosome 1.
DR Bgee; ENSACAG00000004980; Expressed in hindlimb bud and 13 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR GO; GO:0044615; C:nuclear pore nuclear basket; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0070390; C:transcription export complex 2; IBA:GO_Central.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0042393; F:histone binding; IEA:Ensembl.
DR GO; GO:0010484; F:histone H3 acetyltransferase activity; IEA:Ensembl.
DR GO; GO:0006406; P:mRNA export from nucleus; IBA:GO_Central.
DR GO; GO:0034728; P:nucleosome organization; IEA:Ensembl.
DR GO; GO:0016973; P:poly(A)+ mRNA export from nucleus; IEA:Ensembl.
DR GO; GO:0016446; P:somatic hypermutation of immunoglobulin genes; IEA:Ensembl.
DR Gene3D; 1.25.40.990; -; 1.
DR Gene3D; 6.10.250.1340; -; 1.
DR InterPro; IPR031910; GANP_CID_dom.
DR InterPro; IPR031907; MCM3AP_GANP.
DR InterPro; IPR031908; NupH_GANP.
DR InterPro; IPR000717; PCI_dom.
DR InterPro; IPR045107; SAC3/GANP/THP3.
DR InterPro; IPR005062; SAC3/GANP/THP3_conserved.
DR PANTHER; PTHR12436; 80 KDA MCM3-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR12436:SF3; GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN; 1.
DR Pfam; PF16766; CID_GANP; 1.
DR Pfam; PF16769; MCM3AP_GANP; 1.
DR Pfam; PF16768; NupH_GANP; 1.
DR Pfam; PF03399; SAC3_GANP; 1.
DR PROSITE; PS50250; PCI; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT DOMAIN 762..945
FT /note="PCI"
FT /evidence="ECO:0000259|PROSITE:PS50250"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 161..187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 207..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 275..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 344..417
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 494..526
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1894..1913
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1109..1175
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1..17
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..224
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..322
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 401..417
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..526
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1948 AA; 217419 MW; E046EA10BB0FB7C9 CRC64;
MNPNTPFSGQ QPGGFQVPSG PATGIFPAQP SFQFGQPPIF GQNTGSGALL KNPGFTHLTD
FTVTAGARSS LSLGQTPGFA QSYTAAPTTS FVTSAPTYSS VPSKQAFSFK PPTALGPSHC
PPNFGATSTD TSGSGFVGPD FSFKTPENAV FKPIFGTGSG QEKLANTGNQ PSFTFSSPGT
SGSGRLAPFA MSQASSSTAS TSFSFSKPLS SNTSASSFSV ALPSKTTEDD KKRPTVFFAS
PSSSFTSFSN SSTGSLLDPF QMNKTAKLQH EEIVAPVEPH SLFGKGTKRK EEQEPFPRRH
EYDGVDEPEL LSKSDHSPNK RPVRLNRPIR GLFDRTLLDV LKSNKKESKM ENASAESGEM
EQAGAAAESQ TGVAIARPIV ATPRKEDSKA KFKEGAASPN PLRRNRNSGS TESLGGLPPN
ELITFQCKNI PDFLNDRTFL EKHFKKFNIK VQRVRTNRKK KLAIVYCLDH TSAVLARKKA
KDLHEEIVTF WHKKKPSPNK KDYPSTEETA GESSGRQSSD QMSHQLSIRG KALLRSAGSG
NLSTKSSPVK KSVLKKALQF DSIPEGHSFE NVEVSPASFS SLIGMVAETS EDKYRLLDQR
DKIMRQARVK QIDLGKAKTF VGTCPDMCPE KERYMRETRN QLSFFEVIPG TDKVDHAAAV
KEYSRSSADQ EEPLPHELRP SEVLSMTMDY LVTQIMDKGE GNFREWYDFV WNRTRGIRKD
ITQQHLCCPL TVSLIEKCTR FHIHCSHHLC EEPMSSFDAK INNENMTKCL QSLKEMYQDL
ANKGIYCKSE AEFRGYNVLL NLNKGDILRE VQQFRPEVRN SAEVRFAVQA FAALNSNNFV
RFFKLVQKAS YLNACLLHCY FSQIRRDALK SLNVAYTVST QRATIFPLDN VVRMLLFRHL
EDAIDFISYY GLSVSDGFVE LNRSAFLEPE SLPKPKKSLF VGQKLTVSIG EIVSGGPLQP
IIRHVPVCSF NTQNRYTGEN AGVDPTTSNQ KVNVDVTEPR VEVNTMDSEV VCALPSSLLP
PAPLPSTVGS PFQPLTQPLP PPPKPQPVYS DMDISEVVED LVHEVLEMEC REISNAGAAY
VKSAIGVSNV AADELMSEVV LGMSRQIAST VLNAERERFE EEKRRAEEER KRQEKERLIK
TLSESMSANL TDEIINEMIQ EISTMELRCA REKDQKARIA RCSKEVCAEI MGTFLEDEIF
QSAKETLQEL QCFCKYLQRW RDAVVARKKL KRQMRAFPAA PCYMDPKDKL KALSPSAESP
IAREHLAKRI VNLGHAGNLG TSCLRLGWLR SNTIHQMKVQ HFYQQLLRDA VWTPLDLPSL
VAENIPVQQE KVFWKALLVL PSYEEYPAKD PSRILADWLK AKFGIDKNLE EATSVENDGI
KTLALHTSLR TQRDRDIYVS ACIKTTHGTL STSEVEDPGI QKKLLGTSGL ILLLSPRVRS
EDVAEEDIYW LSALLQLKRL LQAKPYQPIV PLVVLVPSRG DEAAEKEVEE GLMLPDLISA
NLISGYKVVE IPDSVSDLQG TRKLSEAVQW LVTQYPSSIN LCCQTLRQYV EDGLDLLFSQ
QFYLDRKERY TAGLCAQDPS AVIELYNNAV QFLAEVVSSE DLYDLSWPVI EFAEPGGSKL
LPHLQWNMPK HLSWLRKAVL SFQIPHMDLP PSGAPWHLVC AMIFQYVSQT ASSPQSQEIL
QSQIENLLSR TYLKWKDKKS MQSSKDGPSV EEIPWDSMLA LCINHKLRDW KPPCLPVAPE
AVNEDGQIHV YFFKEHLGRF GCPFSWEEAR LKTQKMSQQS QGRSKIKTTS FARLYSPSLS
PAEFWASEGK ARNTELTVPS GADLTVTVSE IDALPECLSV KLQQEKAESR RFDERLQQLL
VQDSEIFQDS PSLPLYLPET LVCVPQIIQP LAKPSMAKSP EAGKKELPDP DTSLSHRLQY
LKQQIRANKE EEIACETHLS TLLDVMNM
//
