ID G1KDQ0_ANOCA Unreviewed; 265 AA.
AC G1KDQ0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Homeobox domain-containing protein {ECO:0000259|PROSITE:PS50071};
GN Name=LOC100567438 {ECO:0000313|Ensembl:ENSACAP00000005059.2};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000005059.2, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000005059.2, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000005059.2,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000005059.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
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DR RefSeq; XP_003214980.1; XM_003214932.2.
DR AlphaFoldDB; G1KDQ0; -.
DR STRING; 28377.ENSACAP00000005059; -.
DR Ensembl; ENSACAT00000005172.4; ENSACAP00000005059.2; ENSACAG00000005185.4.
DR GeneID; 100567438; -.
DR KEGG; acs:100567438; -.
DR eggNOG; KOG0489; Eukaryota.
DR GeneTree; ENSGT00940000160059; -.
DR HOGENOM; CLU_049543_4_1_1; -.
DR InParanoid; G1KDQ0; -.
DR OMA; SQNFRIE; -.
DR OrthoDB; 728401at2759; -.
DR TreeFam; TF351530; -.
DR Proteomes; UP000001646; Chromosome 1.
DR Bgee; ENSACAG00000005185; Expressed in ovary and 1 other cell type or tissue.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0021520; P:spinal cord motor neuron cell fate specification; IEA:InterPro.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR042768; MNX1/Ceh-12.
DR PANTHER; PTHR24335; MOTOR NEURON AND PANCREAS HOMEOBOX PROTEIN; 1.
DR PANTHER; PTHR24335:SF3; MOTOR NEURON AND PANCREAS HOMEOBOX PROTEIN 1; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT DOMAIN 116..176
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 118..177
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 177..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 178..196
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..265
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 265 AA; 29875 MW; F884F54BBAE958FC CRC64;
MPKAMEKSQN FRIDALLAEE PRASSQSPPA AFVPKPGLLS LSPPGLYAPA LFPLPALTGQ
AHPALAFAAF PHLPPPPVAE PFKLGASFPL EQWVRAGILA PRFPDFHAGP QSGLMGKCRR
PRTAFTSQQL LELENQFKIN KYLSRPKRFE VATSLMLTET QVKIWFQNRR MKWKRSRKAK
EQVMGAEAEK QRGVSKGSEK LLPGEVQGQE NEEEDIDEEC RRQRASTRFL HHNTETFSYS
PDPSGSEEEE EEMQSSTHRE RSQLL
//
