ID G1KFA4_ANOCA Unreviewed; 650 AA.
AC G1KFA4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=Calcium-binding and coiled-coil domain-containing protein 2 {ECO:0000256|ARBA:ARBA00040931};
DE AltName: Full=Nuclear domain 10 protein NDP52 {ECO:0000256|ARBA:ARBA00041519};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000006207.4, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000006207.4, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000006207.4,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000006207.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Cytoplasm, perinuclear region
CC {ECO:0000256|ARBA:ARBA00004556}. Cytoplasmic vesicle, autophagosome
CC membrane {ECO:0000256|ARBA:ARBA00037854}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00037854}. Membrane
CC {ECO:0000256|ARBA:ARBA00004170}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004170}.
CC -!- SIMILARITY: Belongs to the CALCOCO family.
CC {ECO:0000256|ARBA:ARBA00037963}.
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DR AlphaFoldDB; G1KFA4; -.
DR STRING; 28377.ENSACAP00000006207; -.
DR Ensembl; ENSACAT00000006345.4; ENSACAP00000006207.4; ENSACAG00000006352.4.
DR eggNOG; ENOG502QT1M; Eukaryota.
DR GeneTree; ENSGT00950000183025; -.
DR InParanoid; G1KFA4; -.
DR TreeFam; TF329501; -.
DR Proteomes; UP000001646; Chromosome 6.
DR Bgee; ENSACAG00000006352; Expressed in skeletal muscle tissue and 13 other cell types or tissues.
DR GO; GO:0005776; C:autophagosome; IBA:GO_Central.
DR GO; GO:0000421; C:autophagosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016605; C:PML body; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:1901098; P:positive regulation of autophagosome maturation; IBA:GO_Central.
DR GO; GO:0098792; P:xenophagy; IBA:GO_Central.
DR Gene3D; 2.60.40.2840; -; 1.
DR Gene3D; 6.20.250.40; -; 1.
DR InterPro; IPR041641; CALCOCO1/2_Zn_UBZ1.
DR InterPro; IPR041611; SKICH.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR31915:SF4; CALCIUM-BINDING AND COILED-COIL DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR31915; SKICH DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF17751; SKICH; 1.
DR Pfam; PF18112; Zn-C2H2_12; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 621..641
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS00028"
FT REGION 100..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 253..542
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 650 AA; 74283 MW; 6A2A6EDB89214958 CRC64;
MLQCRCSQGS LKAVDQNDGG WTTTVTGKEA WHASRCGTTL PGSLGKAAPP ASPGLDFGEA
KERERIGFLF RPSRRRLLPV TGKQRLGLSD RQVYGEVFSV PGQGEGEKEG RNSSMEAVPC
NNSDEPPTSA VLLDTCHFSQ VIFTDVEKFY VPGGDITCHY NLSQQIIPRS KDWVGIFRVG
WKTTREYYTF MWAPLPSNAN SSDAELQQVL FKAYYLPKDD EYYQFCYVDQ DGQVRGASVP
FQFRAEAEDD MLVVTTQGEV EEIEQQNTTL LQENQKLKEK QESLREQNED LQKRISVAEG
EVEETMQQNT ALLQENQKLK EKQVSLQKQN EDLQKKLKVA EEEKKEFEEK VCLLQTGTME
LQRAQDRQAL EITSAQTELA AVMENNIKLQ KEKEVLEKSL DNLRLHNEKV NGEVSCLKKQ
ITLLETQSSS TEKELCRVKE ERENILIEQE QLEKKLKITL SHMDQLQSKV QSQQKELGDL
QRVGQDKSRH LEQLKEESRK LNAALLRQQN LEEELKEKTL LFQTLQNEID IKEKENQCLR
RENEGLMVHL PELIDHPPAG LLTQSAEHSG LLFGNPYSAA PEIPETDLVS VKKCPLCNNV
FPDDVEEQEY VDHVQSHLLE CSTCHESFDN KQVYDDHVYC HTLDSHLLKH
//
