ID   G1KFC8_ANOCA            Unreviewed;       723 AA.
AC   G1KFC8;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   29-SEP-2021, sequence version 2.
DT   27-MAR-2024, entry version 72.
DE   SubName: Full=GRB10 interacting GYF protein 2 {ECO:0000313|Ensembl:ENSACAP00000006276.3};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000006276.3, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000006276.3, ECO:0000313|Proteomes:UP000001646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000006276.3,
RC   ECO:0000313|Proteomes:UP000001646};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACAP00000006276.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the GIGYF family.
CC       {ECO:0000256|ARBA:ARBA00038015}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; G1KFC8; -.
DR   Ensembl; ENSACAT00000006416.4; ENSACAP00000006276.3; ENSACAG00000006300.4.
DR   eggNOG; KOG1862; Eukaryota.
DR   GeneTree; ENSGT00940000156108; -.
DR   HOGENOM; CLU_007300_0_0_1; -.
DR   TreeFam; TF325513; -.
DR   Proteomes; UP000001646; Chromosome 3.
DR   Bgee; ENSACAG00000006300; Expressed in hemipenis and 13 other cell types or tissues.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0043204; C:perikaryon; IBA:GO_Central.
DR   GO; GO:1990635; C:proximal dendrite; IBA:GO_Central.
DR   GO; GO:0031982; C:vesicle; IBA:GO_Central.
DR   GO; GO:0048009; P:insulin-like growth factor receptor signaling pathway; IBA:GO_Central.
DR   InterPro; IPR003169; GYF.
DR   InterPro; IPR035445; GYF-like_dom_sf.
DR   PANTHER; PTHR14445; GRB10 INTERACTING GYF PROTEIN; 1.
DR   PANTHER; PTHR14445:SF38; GRB10-INTERACTING GYF PROTEIN 2; 1.
DR   Pfam; PF02213; GYF; 1.
DR   SMART; SM00444; GYF; 1.
DR   SUPFAM; SSF55277; GYF domain; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT   DOMAIN          1..36
FT                   /note="GYF"
FT                   /evidence="ECO:0000259|SMART:SM00444"
FT   REGION          265..386
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          415..441
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          455..492
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          534..557
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          672..694
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        265..345
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        346..386
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        415..435
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        462..492
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        535..554
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   723 AA;  85210 MW;  722C60470B2C1528 CRC64;
     MTEWFQAGYF TMSLLVKRAC DENFQPLGDI MKMWGRVPFT PGPAPPLHLG ELDQERLTRQ
     QEYTAMYQMQ HLQYQQFLLQ QQYAQVMAQQ QKAALSSQQQ QQLALLLQQF QALKMRKAEQ
     NMVPPVTRSV TDNGSIWELQ SPAPQATVWE GSSVWDLPID AAAQGPALEQ LQQLEKAKAA
     KLEQERREAE LRAKREEEER KRQEELRRQQ EEIIRRQEEE RKRREEEELA RRKQEEALRR
     QREQEIALRR QREEEERQQQ EEALRRLEER RREEEERRQR EELLRKQEEE AAKWAREEEE
     AKRQLEENRL RMEEEAARQR HEEEERKRKE LELQRQKEIM RQRQQQQEAL RRLQQQQQQQ
     QLAQMKLPSS STWGQQSNSR GCQSQAALSL AEIQKLEEER ERQLQEEQRR QQRELMKALQ
     QQQQQQQQQQ KLSGWGNVAK PAGTTKSLLE IQQEEARHMQ KQQQQQHQQQ NRSRSTTQHS
     NLHTSIGNSV WGTLSTSPNS QWASDLVSSI WSNADTKNSN IGFWDDAVKE VGPRNATNKN
     KSNASISKSV GVTSRPNKKV EEEEKLLKLF QGVNKAQDGF TQWCEQMLHA LNTANNLDVP
     TFVSFLKEVE SPYEVHDYIR AYLGDTPEAK EFAKQFLERR AKQKANQQRQ QQDSVWGMNH
     SSLHSVFQTN QSNNQQSNFE AVQSGKKKKK QKMVRADPSL LGFSVNASSE RLNMGEIETL
     DDY
//