ID G1KHR0_ANOCA Unreviewed; 1280 AA.
AC G1KHR0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Adhesion G protein-coupled receptor G6 {ECO:0000313|Ensembl:ENSACAP00000008228.4};
GN Name=ADGRG6 {ECO:0000313|Ensembl:ENSACAP00000008228.4};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000008228.4, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000008228.4, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000008228.4,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000008228.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR RefSeq; XP_016853867.1; XM_016998378.1.
DR AlphaFoldDB; G1KHR0; -.
DR STRING; 28377.ENSACAP00000008228; -.
DR Ensembl; ENSACAT00000008405.4; ENSACAP00000008228.4; ENSACAG00000008206.4.
DR GeneID; 100561093; -.
DR CTD; 57211; -.
DR eggNOG; KOG3714; Eukaryota.
DR eggNOG; KOG4193; Eukaryota.
DR GeneTree; ENSGT00940000155621; -.
DR HOGENOM; CLU_002753_3_3_1; -.
DR InParanoid; G1KHR0; -.
DR TreeFam; TF321769; -.
DR Proteomes; UP000001646; Chromosome 1.
DR Bgee; ENSACAG00000008206; Expressed in heart and 12 other cell types or tissues.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0043236; F:laminin binding; IBA:GO_Central.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0019933; P:cAMP-mediated signaling; IEA:Ensembl.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0060347; P:heart trabecula formation; IBA:GO_Central.
DR GO; GO:0022011; P:myelination in peripheral nervous system; IBA:GO_Central.
DR CDD; cd00041; CUB; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR001759; Pentraxin-related.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF290; ADHESION G-PROTEIN COUPLED RECEPTOR G6; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF01825; GPS; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51828; PTX_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00059};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..35
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 36..1280
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5032699877"
FT TRANSMEM 890..913
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 925..946
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 952..974
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 994..1015
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1050..1078
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1099..1119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1125..1147
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..149
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 888..1148
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT DISULFID 94..111
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
SQ SEQUENCE 1280 AA; 143083 MW; 4144436774E95EB4 CRC64;
MMSYENQMWW CYQWKWKLHL LFLFVLYLMC VQCSALRCSD CRMVLSNPTG IFTSPCFPND
YPNSQACKWT IRAPSGFIIQ ITFVDFEIEE APNCIYDFLR LHTGEKEVTL CGITARGLSF
NSSGNEMIVS FTSDFSIQKR GFNASYTRVA VALRNQKVII PQFWTDTVSL ANSIQVPELN
QFTLCFEATE NNGSSHNWKA FSYCDSSATE FFSFGKTKGG HFIFISDTEC MLNDALDTNP
DGDFFTETFE QLCIVWDSYS GTIGVNVKHT YKTVFCSDSY GKVIPANGKL VLGSDRKDIN
PLNGDIYNFR LWNFTMNSQV LSNLSCDVKG SIIDWETDFW SIPTSALKAE NNLSCGSYLI
PLPTVEPTSC ANLGGVCQAS VNSTTTSPTV TTNMPDTNRT DKQTDATVNS IITSPIVTTN
TPDTNRTDKQ TNGGLFYRIA FTVYSDKDIS ESNVQSAVAN WLNHTFQDWN YTVYVVNISI
QPSAMKDRAR EKRNVDHQSF DVRALLVYNA TNNISLEEQT IERKLESNNV SIGNGWRVKK
VDVHPVEKCE NEENPPNYIW ADTRPTVTES ILCHGSSTQI ASRVCLLNLD NFTSYWGPPD
LRNCTENAAD IANQLLNLTG EGQQLTSDKV NDVIQKLKKI VNDEEINESL GSTVVTIFSN
ILTSSDSVLA ASSSEAIKTI DALALKIQFT GPSMSISAKN LALGVSLLNS TSFTGSSFSV
GTQNNASDFQ IDFDKNQENS LASVALPESL LKNLSQEDIE IVSRAQFTFF NKSGLFQDAG
SNTSLISYVV ACSIGNITIR DLQDSVRITI KHTVKNDKSQ KTSNPTCAFW DMDKNKGLGG
WNKTGCVLQA ASSDDETVCL CSHLTHFGVL MDLPGTAPQI DPENTKALTF ITYIGCGISA
IFSAATLLTY IAFEKLRRDY PSKILMNLST ALLCLNLAFL LDGWIASFDI EGLCIAIAAL
LHYFLLATFT WMGLEAVHMY IALVKVFNTY IRRYILKFCI IGWGLPAVVI IIVLASTNAN
ASRIYNKDLY GKNTKGQGGD EFCWIQDNTV FYLTCVGYFG IMFLMNIAMF VVVMMQICGR
NGKRSNRTMR EEILRNLRSV ISLTFLLGMT WGFAFFAWGP LYLPFMYLFC IFNSLQGLFI
FVFHCAMKEN VQKQWRRHLC CGRFKLADNS DWSKTATNII KKSSDNLGKS LSSSSIGSNS
TYLTSKSKST CNTFLKRNSH SDNVFLDKAS PKYIQVDTEQ SSIIPVHQVI DKVKGYYNTH
SDNFYRNIIM SDSLSHSTKF
//
