ID G1KJE0_ANOCA Unreviewed; 857 AA.
AC G1KJE0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=LDL receptor related protein 12 {ECO:0000313|Ensembl:ENSACAP00000009648.3};
GN Name=LRP12 {ECO:0000313|Ensembl:ENSACAP00000009648.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000009648.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000009648.3, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000009648.3,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000009648.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR RefSeq; XP_003219476.1; XM_003219428.3.
DR AlphaFoldDB; G1KJE0; -.
DR STRING; 28377.ENSACAP00000009648; -.
DR Ensembl; ENSACAT00000009845.3; ENSACAP00000009648.3; ENSACAG00000009840.3.
DR GeneID; 100564251; -.
DR KEGG; acs:100564251; -.
DR CTD; 29967; -.
DR eggNOG; KOG1215; Eukaryota.
DR GeneTree; ENSGT00940000158307; -.
DR HOGENOM; CLU_013747_0_0_1; -.
DR InParanoid; G1KJE0; -.
DR TreeFam; TF332149; -.
DR Proteomes; UP000001646; Chromosome 4.
DR Bgee; ENSACAG00000009840; Expressed in testis and 13 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0001764; P:neuron migration; IEA:Ensembl.
DR GO; GO:0031175; P:neuron projection development; IEA:Ensembl.
DR CDD; cd00041; CUB; 2.
DR CDD; cd00112; LDLa; 4.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 5.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 2.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR24252; ACROSIN-RELATED; 1.
DR PANTHER; PTHR24252:SF7; HYALIN; 1.
DR Pfam; PF00431; CUB; 2.
DR Pfam; PF00057; Ldl_recept_a; 4.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00042; CUB; 2.
DR SMART; SM00192; LDLa; 5.
DR SUPFAM; SSF57424; LDL receptor-like module; 5.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 2.
DR PROSITE; PS01180; CUB; 2.
DR PROSITE; PS01209; LDLRA_1; 2.
DR PROSITE; PS50068; LDLRA_2; 5.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..34
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 35..857
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5032981212"
FT DOMAIN 49..161
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 259..372
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT REGION 622..674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 688..723
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 743..769
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 631..662
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 691..705
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 743..757
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 168..180
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 175..193
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 187..202
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 239..254
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 395..410
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 433..448
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 451..463
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 458..476
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 470..485
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 857 AA; 93990 MW; F4C672F1365DA5D6 CRC64;
MASCWSAKGS LAWRSAQLLL LVAAASCRGN SALAEHSENV HISGVSTACG DIPEQIKGPS
GIITSPGWPL EYPVRLNCSW YIRANPGEII TISFQDFDVQ GSRRCSLDAL TIGAYKNMEN
YRVCGSSIPS PYISSQDHVW IRFHSDDSIS RKGFRLAYFA GKSSETSCDC NQFHCSNGKC
IPESWKCNDM DECGDNSDEE ICVKAGPPTA AAFQPCGYNQ FQCLSRFNVY TCIPESSKCD
GNLDCLDLGD EIDCGVPTCG QLLKYFYGTF NSPNYPDFYP PGSNCTWLID TGDHRKVILR
FTDFKLDGTG YGDYVKIYDG LEENPRKLLR VLTAFDSHAP LTVVSSSGQI RVHFCADKVN
AARGFNATYQ VDGFCLPWEI PCGGNWGCYT EQQRCDGYWH CPNGRDETNC TMCQKDEFPC
SRNGACYPRS DRCNYQNHCP NGSDEKNCFF CQPGNFHCKN NRCVFESWVC DSQDDCGDGS
DEENCPVIVP TRVITAAVIG SLICGLLLVI ALGCTCKLYS LRMFERRSFE TQLSRVEAEL
LRREAPPSYG QLIAQGLIPP VEDFPVCSPN QASVLENLRL AVRSQLGFTS IRLPIAGRSS
NIWNRIFNFA RSRHSGSLAL VSSDGDDIAS QNTNRESERN GSHRSLFSVE SDDTDTETER
RDAAGAVGGV AATLPQKVPP TTAVEAPVVC GTPSVQNTSS NADHGREAAS IEPPNSSPGR
HQFSNALSRM TQGLRWVRFT LGRSSPANQN QSPLRQLDNG VGGGRDEDDD VEMLIPVSDV
ASDLDVNDCS RPLLDLTSDQ GQGLRQPYSS SHNGVRSCNR DGPCERCGIV HTAQIPDTCL
EATLKNETSD DEALLLC
//
