ID G1KKV3_ANOCA Unreviewed; 331 AA.
AC G1KKV3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 85.
DE RecName: Full=ALX homeobox protein 1 {ECO:0000256|ARBA:ARBA00014029};
DE AltName: Full=Cartilage homeoprotein 1 {ECO:0000256|ARBA:ARBA00032590};
GN Name=ALX1 {ECO:0000313|Ensembl:ENSACAP00000010899.1};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000010899.1, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000010899.1, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000010899.1,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000010899.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00108, ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the paired homeobox family.
CC {ECO:0000256|ARBA:ARBA00005733}.
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DR RefSeq; XP_003221183.1; XM_003221135.3.
DR AlphaFoldDB; G1KKV3; -.
DR STRING; 28377.ENSACAP00000010899; -.
DR Ensembl; ENSACAT00000011126.3; ENSACAP00000010899.1; ENSACAG00000011108.3.
DR GeneID; 100562225; -.
DR KEGG; acs:100562225; -.
DR CTD; 8092; -.
DR eggNOG; KOG0490; Eukaryota.
DR GeneTree; ENSGT00940000158251; -.
DR HOGENOM; CLU_047013_0_1_1; -.
DR InParanoid; G1KKV3; -.
DR OMA; TEHNTRM; -.
DR OrthoDB; 5400675at2759; -.
DR TreeFam; TF350743; -.
DR Proteomes; UP000001646; Chromosome 5.
DR Bgee; ENSACAG00000011108; Expressed in forelimb bud and 5 other cell types or tissues.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0016604; C:nuclear body; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of DNA-templated transcription; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR GO; GO:0010718; P:positive regulation of epithelial to mesenchymal transition; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR003654; OAR_dom.
DR PANTHER; PTHR24329:SF359; ALX HOMEOBOX PROTEIN 1; 1.
DR PANTHER; PTHR24329; HOMEOBOX PROTEIN ARISTALESS; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR Pfam; PF03826; OAR; 1.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
DR PROSITE; PS50803; OAR; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Repressor {ECO:0000256|ARBA:ARBA00022491}.
FT DOMAIN 135..195
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DOMAIN 311..324
FT /note="OAR"
FT /evidence="ECO:0000259|PROSITE:PS50803"
FT DNA_BIND 137..196
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
SQ SEQUENCE 331 AA; 36521 MW; 036FC05887720B29 CRC64;
MEFLGDKFGL KGPAAGKGGD FYLSPGAPLE HVMEGLEGGG GGGTGGGGEA FYGKGGKCVG
QAPYNPHARM ERASPAREGS VTYGITKVEG QPLHTELGRP LDNCSSLRLS PVKGMQEKGD
LDELGDKCDS NVSSSKKRRH RTTFTSLQLE ELEKVFQKTH YPDVYVREQL ALRTELTEAR
VQVWFQNRRA KWRKRERYGQ IQQAKSHFAA TYDISVLPRT DNYPQIQNNL WAGNAASSSV
VTSCMLPRDT SSCMTPYSHS PRTDSGYSGF SNHQSQFSHV PLNNFFTDSL LSGTTNGHAF
ETKPEFERRS SSIAVLRMKA KEHTANISWA M
//
