ID G1KL59_ANOCA Unreviewed; 3691 AA.
AC G1KL59;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Ankyrin 2 {ECO:0000313|Ensembl:ENSACAP00000011203.3};
GN Name=ANK2 {ECO:0000313|Ensembl:ENSACAP00000011203.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000011203.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000011203.3, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000011203.3,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000011203.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR STRING; 28377.ENSACAP00000011203; -.
DR Ensembl; ENSACAT00000011439.3; ENSACAP00000011203.3; ENSACAG00000010704.3.
DR eggNOG; KOG4177; Eukaryota.
DR GeneTree; ENSGT00940000155279; -.
DR HOGENOM; CLU_000134_29_2_1; -.
DR TreeFam; TF351263; -.
DR Proteomes; UP000001646; Chromosome 5.
DR Bgee; ENSACAG00000010704; Expressed in testis and 10 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051179; P:localization; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08804; Death_ank2; 1.
DR Gene3D; 2.60.220.30; -; 3.
DR Gene3D; 2.60.40.2660; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 3.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR040745; Ankyrin_UPA.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR24123:SF49; ANKYRIN REPEAT AND DEATH DOMAIN-CONTAINING 1B; 1.
DR PANTHER; PTHR24123; ANKYRIN REPEAT-CONTAINING; 1.
DR Pfam; PF00023; Ank; 3.
DR Pfam; PF12796; Ank_2; 4.
DR Pfam; PF13637; Ank_4; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF17809; UPA_2; 1.
DR Pfam; PF00791; ZU5; 3.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 15.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 2.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 15.
DR PROSITE; PS50088; ANK_REPEAT; 15.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS51145; ZU5; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 34..66
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 67..99
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 100..132
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 133..165
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 166..198
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 199..231
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 232..264
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 265..297
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 298..330
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 331..363
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 364..396
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 397..429
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 430..462
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 463..495
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 496..528
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 708..896
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 898..1045
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 3213..3297
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 1197..1226
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1416..1493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1510..1812
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1874..1921
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1939..1967
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1983..2005
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2077..2238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2255..2397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2442..2463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2711..2737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2776..2861
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2905..2985
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3026..3107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3333..3358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3424..3468
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3661..3691
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1419..1434
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1446..1473
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1510..1525
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1535..1549
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1567..1598
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1605..1661
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1684..1737
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1758..1780
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2086..2103
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2165..2207
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2224..2238
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2255..2272
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2284..2310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2311..2330
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2344..2366
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2367..2386
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2446..2463
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2713..2737
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2778..2792
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2793..2810
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2932..2959
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3027..3076
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3087..3101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3333..3355
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3424..3443
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3691 AA; 407487 MW; 23271362AA50D3B9 CRC64;
MESLHCMWLP KGGTQTWVKL LLDRGGQIDA QTRDGLTPLH CAARSGHDQV VKLLLERGAL
LLPRTKNRLS PLHMAAQGDH VECVKHLLQH KAPVDDVTLD YLTALHVAAH CGHYRVTKLL
LNKKANPNTF ALNGFTPLHI ACKKNRIKVM ELLVKYGASI HAITESGLTP IHVAAFMGHL
NIVLLLLQNG ASANFINIRG ETALHMAVRA GQVEVVRCLL RNGAMVDFRA REKQTSLHIA
SRLGKTEIVQ LLLQHMAYPD AATTNGYTPL HISAREGQVD IASVLLEAGA AHSLATKKGF
TPLHVAAKYG SLDVAKLLLQ HHASPDSSGK NGLTPLHVAA HYDNQKVALL LLEKGSSPHA
TAKNGYTPLH IAAKKNQMQI ATTLLNYGAE TNILTKQGVT PLHLASQEGH ADMVNLLLEK
GVNIHVATKS GLTSLHLAAQ EDKVNVADML IKHGANKDAQ TKLGYTPLIV ACHYGNIKMV
NFLLKQGANV NAKTKNGYRP LHQAAQQGHT HIINVLLQHG AKPNATTANG NTALAIAKRL
GYISVVDTLK VVTEEVVTTT TTVTEKHKLN VPETMSEVLD VSDEEGDDTM TGDGGEYLRP
EDLKELGDDS LPSSHFIGCM NYLRHSLEEG RSDSTMPSLR SFSSDKSHTL SHISYLRDST
MIDDAVVIPS HQVTTLAKEG ERTSYHLSWS PDTLDNVSLY DGPIHSSFLV SFMVDARGGA
MRGCRHNGLR IIIPPRKCTA PTRVTCRLVK RHRLATMPPM VEVEGLASRI IEVGPSGAQF
LGKLHLPTAP PPLNEGESLV SRILQLGPPG TKFLGPVIVE IPHFAALRGK ERELVILRSE
NGDNWKEHFC EYTEDELNEI LNGMDEVLDT PEELEKKRIC RIITRDFPHY FAVVSRIKQD
SNLIGPEGGV LSSTVVPQVQ AVFPEGALTK RIRVGLQAQP MHHELVKKIL GNKATLSPIV
TLEPRRRKFH KPITMTISVP KASNDMMING YGNEAPTLRL LCSITGGVTP AQWEDITGTT
PLTFVNECVS FTTNVSARFW LIDCRQMHES VTFASQVYRE IICVPYMAKF VVFAKSQDPI
EARLRCFCMT DDKVDKTLEQ QENFSEVARS RDVEVLEGKP IFVDCFGNLV PLIKSGQHHI
FSFYAFKENR LPLFVKVRDS TQEPCGRLSF MKEPKSSRGL VHQAICNLNI TLPVYTKESE
SDQEQEEETE MSSEKHDDET ESTETSILKS HLVNEVPVLA SPDLLSEVSE MKQDLIKMTA
ILTTDLSEKP GSIKVKDFAK AADEEPGEPF EIVERVKEDL EKVNEILRSG SCPKEKPVLQ
RSNSGRELVE EEWVILSDEE IEEAKQNVPL EVAEPLCTEM RIGKGKTEKG TKDATGMVDY
LSDDLKAFVS LNEVHPKTIQ EDIVGEKCEV VILNRGSEPG KGDQEKQRQH KPTLEIKKTV
RKKLKYKPKA NDEEDQAKEK HSGLTKFSSE ESLDEESGLA PAQPAKATAV SPVVEEIPIG
FIKDKVKAFQ KRVEDEQKGR SKLPVRAPGK EGTTEKSVTK PSQTKKIIYK TKSPACPPAS
KSAAYPLASK TPASLSSSKT PASPSPSKLS SPSAKKPAVS PTSKKPPVSP TTKKPAVSPT
SKKPPVSPTT KKPAVSPTTK KPAVSPTTKK PPISPSSKTE RLEETMSVRE LMKAFQAGQD
PSKHKAGLFE HKPIKQKQQA ADKEPAKKGT AQAESEKKQA LTQKETPKKD SPKSKRGQEP
QAETGLQLKK ETKNIPLKKG LATQQAKQQS SKTTGKKSPV VDESSKAVAL VVDDQGDPDL
QISPDRKTST DFSEVIKEEL EDNDKYQQFR NISITEEGEL HLDQVLTSPF NVTFTSEYVK
DGFLPTLSLQ SGALDGSSES LKHEGIADSP IGSLLGGTPQ NSSEESYKHE GLAETPETSP
ESLLFSLKKS DIADQMEEAE LASAVQRKAE THSPKGLSPN ESEKTVADQE LKAVTEISEF
QSHHLSEEQV TTSKEEIGKC IDSSSTSVSK DVIRDELSVA ADKGHLTELS EIHISSLEKD
EGASLEHHAI SKGLELSLPI NDSEGLSPVA DESIAISHKD SLEASPVLED NSSRKTPDSL
EPSPTKESPC HDSLESSPVE ERIKTGMLPG PGPIQSILAK AENFPELTPM RSRLLRDPDG
SAEDDSLEQT SLMESSGKSP LSPETPSSEE ISYEITPKLT DSHVLSNIPK SAVIPEVNEE
PEDDPEGEPK KRFTPEEEMF KMVTKVKMFD ELEQEAKQKR DYKKDSKQDD VASASDLEAT
PEVEIAPSSN TEDSSIPTVV TSAVDTRKSS SSSESEPELT KLKKEADSGL LMEPLIRVQP
PSPHLCNMDS SSSPEETGFQ PIESKQHAFS TEEDNTESDK PTEETKMSGD TSLASDASII
AQASESKCYS TDESDTVSPN GPVMPPEESF YHSIGDGALK EAESYETSVT SHHHDDSEKD
FTATEDVPHR GPFLAGTTEV SCQPGTSHCC TPQNYELATF VSPDHSPLGC DMAGTDNDFE
MAQRDCCSPE HSKEYSSLIT QKGECEDNVE NNAESSYLPI TSPYENVPSQ HFFTNTQIRT
EMDLRTTSDP SSRGDHYGET ENTLKKSMYR SESPGSGDQT SGEIYMEIES KQVDIFHKIP
SPTPTRSNPA SLDDEALQDI RDEAEKIINQ VIITRTDVDS DKWSQIREDD DAFDARVKEE
EQKIFGLMVD RRSQGTTPDT TPARTPTEEG TPTSEQNPFL FQEGKLFEMT RSGAIDMTKR
NYSDENLHFF QVGEHSQEEV SLSEEMKEAE VLESSQQDQT SIQSASSELG KAEMHTKDSQ
LSVSEDEANG LPSSKGDIKS RIPIKMGISA SSKSPKKETV ASDVDSIYTL DTSDMLDSSQ
VPCPLSPEQT VIDVQLNFST ITRSVYAEQD DSPDSSPEEQ KSVIEIPTAD IENVPSSESK
SKIPVKTCPS TTHSLHQSEP VCLPSVDLAD NLEESQDDPS TPKSKIPVKV VFQRVEKECM
YTETSIWKPE SSKSLDITCT LPMKQDIRSK SESDTSVSMD PKAKRSVKAR SYVEAEAEAR
ERGSDMNLEL ESDELPTARP KILSSRLPVK SRSTSASHSD VSPSKESKEH FFDLYKNSIE
FFEEISDEAS KLVDRLTQSD KEQELVSDDE SSSALEVSVI ENVPSIETLQ SVAEDIFDTR
PIWDESIETL IERIPDENVP DHVEDQQDDR ERTEERLAHI ADHLGFSWTE LARELDFTEE
QIHQIRIENP NSLQDQSHAL LKYWLERDGK HATDSSLTDC LTKINRMDIV HLMESNVEMV
RNHGHTYAEI EQSMGLDHSE GFSALHEDLY STRDKKEEEH SFSKDSEKSD HPPLVSEEDL
SVTYSPLHES TPRVEAEVSV VELLRQTHKD RVEAEFSGTP DTLTEDSSAV TQEYLVTTSV
IAKTQASKAG KTASTASEKT EGSTAVSEDL ERTFLHTPTS SERTDSPIVQ EPEDHHYHQE
DIHPRKNSLV IVESIDEQPE KSERYEEELL EKEIAEELGE LEASSDEEQM VTTRVVRRRV
IIQADDMLEM PPEAVTEEQY TDEHGHIVVK KVTRKIIRRF VLPDGTEKEE VVMQGEPQEP
VTVEEGDGFS KVIKRVVLKS DSEQSELTFA EPSVLSSASE FQSEPVEGRK VSKVVKTTVV
HGERMEKHHG DSSLATDLPS AKDDFEEDNN E
//
