ID G1KMJ6_ANOCA Unreviewed; 300 AA.
AC G1KMJ6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Hydroxysteroid 17-beta dehydrogenase 13 {ECO:0000313|Ensembl:ENSACAP00000012371.2};
GN Name=HSD17B13 {ECO:0000313|Ensembl:ENSACAP00000012371.2};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000012371.2, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000012371.2, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000012371.2,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000012371.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|RuleBase:RU000363}.
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DR RefSeq; XP_003221340.1; XM_003221292.3.
DR AlphaFoldDB; G1KMJ6; -.
DR STRING; 28377.ENSACAP00000012371; -.
DR Ensembl; ENSACAT00000012624.4; ENSACAP00000012371.2; ENSACAG00000012491.4.
DR GeneID; 100561640; -.
DR KEGG; acs:100561640; -.
DR eggNOG; KOG1201; Eukaryota.
DR GeneTree; ENSGT00940000161743; -.
DR HOGENOM; CLU_010194_2_5_1; -.
DR InParanoid; G1KMJ6; -.
DR OMA; NTLAHYW; -.
DR OrthoDB; 6845at2759; -.
DR TreeFam; TF312837; -.
DR Proteomes; UP000001646; Chromosome 5.
DR Bgee; ENSACAG00000012491; Expressed in kidney and 9 other cell types or tissues.
DR GO; GO:0005811; C:lipid droplet; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR GO; GO:0046889; P:positive regulation of lipid biosynthetic process; IEA:Ensembl.
DR CDD; cd05339; 17beta-HSDXI-like_SDR_c; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR002347; SDR_fam.
DR PANTHER; PTHR24322:SF750; IP10670P-RELATED; 1.
DR PANTHER; PTHR24322; PKSB; 1.
DR Pfam; PF00106; adh_short; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 300 AA; 33020 MW; E3C8AF4D81BF6AD9 CRC64;
MNIIFDLLQV VVIIIYSYLE ALVKLFIPVK RKSVSGETVL ITGAGHGIGR VTAYEFAKRQ
SKLILWDINK HGVEETAEGC KKLGAKAYSF VVDCSVKEEI YAAAEKVKRE IGDVTILVNN
AGVVATADLL STKDEQIQKI FEVNILAHHW TIKAFLPAMM ESNHGHIVTV ASAGGHVTVP
FLVSYCSSKF AAVGFHKALT QELAALGKDG IKTSCLCPVF INTGFVKQPR SRLVPILEPE
KVANALMDGI LCNQKMIFVP PFVKFNLLLE RILPERALVA LNKMLRIDFD AVVQGEKKKD
//
