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Database: UniProt
Entry: G1KMZ7_ANOCA
LinkDB: G1KMZ7_ANOCA
Original site: G1KMZ7_ANOCA 
ID   G1KMZ7_ANOCA            Unreviewed;      1899 AA.
AC   G1KMZ7;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 2.
DT   25-OCT-2017, entry version 48.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN4A {ECO:0000313|Ensembl:ENSACAP00000012689};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000012689, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000012689, ECO:0000313|Proteomes:UP000001646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000012689};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACAP00000012689}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSACAP00000012689}.
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DR   RefSeq; XP_008111415.1; XM_008113208.2.
DR   STRING; 28377.ENSACAP00000012689; -.
DR   Ensembl; ENSACAT00000012945; ENSACAP00000012689; ENSACAG00000012739.
DR   GeneID; 100555864; -.
DR   CTD; 6329; -.
DR   eggNOG; ENOG410INF8; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; G1KMZ7; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000001646; Chromosome 6.
DR   Bgee; ENSACAG00000012739; -.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IBA:GO_Central.
DR   GO; GO:0086010; P:membrane depolarization during action potential; IBA:GO_Central.
DR   GO; GO:0019228; P:neuronal action potential; IBA:GO_Central.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   SMART; SM00015; IQ; 1.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001646};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    124    147       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    192    211       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    223    244       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    250    270       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    372    389       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    409    436       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    606    624       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    636    659       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    671    695       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    716    744       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    804    829       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1077   1095       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1116   1138       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1193   1219       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1320   1343       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1402   1420       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1432   1450       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1457   1482       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1519   1549       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1569   1586       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1623   1646       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      127    443       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      607    833       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      843   1071       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1075   1351       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1401   1656       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      444    478       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1899 AA;  216961 MW;  5B7EC6AF4373EB6C CRC64;
     MAPPPIPPGP DSLRRLTRES IVEIEKRFAE EEAKKLKPPE ETLEEVVERK PRSDLEQGKS
     LPLIYGDPPP ELLGVALEEL DPFYSDKKTY ILLSKGKTIF RFSTTPALYM LDPFNIVRRG
     AIQVLIHSLF SMFIMITILT NCVFMAMSNP PSWAKNVEYT FTGIYTFEST IKILARGFCV
     DSFTFLRDPW NWLDFSVIVM AYLTEFVDLG NVSALRTFRV LRALKTITVI PGLKTIVGAL
     IQSVKKLSDV MILTVFCLAV FALIGLQLFM GNLRQKCVRW PPFTNDTLEE DFFGLESNST
     LYDNFGNSTL YDNDTLTSNF TFDWDEYIHN EENFYFLDGA LDALLCGNSS DAGQCPEGYQ
     CMKAGRNPNY GYTSYDTFSW AFLALFRLMT QDYWENLFQL TLRAAGKTYM IFFVLVIFLG
     SFYLINLILA VVAMAYDEQN QQTMLEEQEK EAEFQQMMEQ LKKHQEEQER LLQEAAANSS
     STESIIVKNK GESDQEGHSD QDGPKDCNRP AIPRLVLERS ATVDESDSME EHEKSDQNHL
     QVNTGLEKRA GSALSIVSNT MEELEEAHQK CPPWWYKFAN AVLVWNCCPF WVKLKHILKL
     IVMDPFVDLG ITICIVLNTV FMAMEHYPMT EEFNNVLTVG NLVFTGIFTA EMVLKLIALD
     PYEYFQVGWN IFDSIIVTLS LVELALANVQ GLSVLRSFRL MRVFKLAKSW PTLNMLIKII
     GNSVGALGNL TLVLAIIVFI FAVVGMQLFG KSYIECVCKI SSDCELPRWH MHDFFHSFLI
     VFRILCGEWI ETMWDCMEVA GQTLCLIVFM MVMVIGNLVV LNLFLALLLS SFSADSLAGS
     DEDGEMNNLQ IAIARITRGI DYVKKHVLLL LHRELKQKTE PPAEEQDDSK KENFVLNHTD
     TGQDFKLEIM DGMPKKEGQG FKSEFMDGLS KNDSQDFRSD YMDGIRRKEP FIDELEQMNF
     INNPNLTIHV PIASEESDLY DETDTGEETA EETKETKKFL SDGTESSICS TVDYKPPDPM
     EEEAVAEEAV ENDEPEECFT EACVQRCPCL YVDIKTEKGQ KWWNLRKTCF KIVEHNWFET
     FIIFMILLSS GALAFEDIYI ERRPVIRTIL EYADKVFSYV FVIEMLLKWV AYGFKVYFTN
     AWCWLDFLIV DVSLISLTAN WMGYSELGPI KSLRTLRALR PLRALSRFEG MRVVVNALLG
     AIPSIMNVLL VCLIFWLIFS IMGVNLFAGK YYRCVNTTTG ELFEISEINN KSDCMNLINI
     ENATDVRWLN VKVNFDNVGL GYLSLLQVAT FKGWMDIMYA AVDSREVEEQ PQYEINLYMY
     IYFVVFIIFG AFFTLNLFIG VIIDNFNQQK KKFGGKDIFM TEEQKKYYNA MKKLGSKKPV
     KPIPRPQNKY QGMIFDFVTQ QAFDIVIMIL ICLNMVTMMV ETDDQSQTKI DILFQINLIF
     IVIFTTECFL KMIALRYYFF TVGWNIFDFV VVILSIAGLV LSDLIEKYFV SPTLFRVIRL
     ARIGRVLRLI RGAKGIRTLL FALMMSLPAL FNIGLLLFLV MFIFSIFGMS NFAYVKKESG
     IDDMFNFETF GNSIICLFMI TTSAGWDGLL NPILNSAPPD CDPDLENPGS DVKGNCGNPG
     VGICFFCTYI IVSFLIVVNM YIAIILENFN VATEESSEPL CEDDFEMFYE TWEKFDPDAT
     QFIDYSILSE FADTLQEPLR IAKPNKIKLV TLDLPMVPGD KIHCLDILFA LTKEVLGDSG
     EMDALKESME EKFMAANPSK VSYEPITTTL KRKHEEVCAT KIQRAFRRYL LRRSVKQASY
     VYRHSQDEDT LAEGAPEKEG LIANRINTLY GSSEMQMENE ISPEASPPIE LEPIPSPENT
     QDTGETKEKE EEPEKTTEDA SSKTQEPKAT KRGVKESFV
//
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