ID   G1KN22_ANOCA            Unreviewed;       658 AA.
AC   G1KN22;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 2.
DT   27-MAR-2024, entry version 66.
DE   RecName: Full=Choline/carnitine acyltransferase domain-containing protein {ECO:0000259|Pfam:PF00755};
GN   Name=LOC100564964 {ECO:0000313|Ensembl:ENSACAP00000012739.3};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000012739.3, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000012739.3, ECO:0000313|Proteomes:UP000001646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000012739.3,
RC   ECO:0000313|Proteomes:UP000001646};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACAP00000012739.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC       {ECO:0000256|ARBA:ARBA00005232, ECO:0000256|RuleBase:RU003801}.
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DR   RefSeq; XP_003216432.1; XM_003216384.3.
DR   AlphaFoldDB; G1KN22; -.
DR   STRING; 28377.ENSACAP00000012739; -.
DR   Ensembl; ENSACAT00000012995.4; ENSACAP00000012739.3; ENSACAG00000012981.4.
DR   GeneID; 100564964; -.
DR   KEGG; acs:100564964; -.
DR   eggNOG; KOG3719; Eukaryota.
DR   GeneTree; ENSGT01060000248556; -.
DR   HOGENOM; CLU_013513_4_2_1; -.
DR   InParanoid; G1KN22; -.
DR   OrthoDB; 1429709at2759; -.
DR   TreeFam; TF315202; -.
DR   Proteomes; UP000001646; Chromosome 2.
DR   Bgee; ENSACAG00000012981; Expressed in brain and 2 other cell types or tissues.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   GO; GO:0004095; F:carnitine O-palmitoyltransferase activity; IBA:GO_Central.
DR   GO; GO:0006635; P:fatty acid beta-oxidation; IBA:GO_Central.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR   Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR   InterPro; IPR000542; Carn_acyl_trans.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR039551; Cho/carn_acyl_trans.
DR   InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR   PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR   PANTHER; PTHR22589:SF53; CHOLINE_CARNITINE ACYLTRANSFERASE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00755; Carn_acyltransf; 1.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR   PROSITE; PS00439; ACYLTRANSF_C_1; 1.
DR   PROSITE; PS00440; ACYLTRANSF_C_2; 1.
PE   3: Inferred from homology;
KW   Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW   ECO:0000256|RuleBase:RU003801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003801}.
FT   DOMAIN          54..640
FT                   /note="Choline/carnitine acyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF00755"
FT   ACT_SITE        374
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ   SEQUENCE   658 AA;  75935 MW;  61D3B95738D9CBB6 CRC64;
     MPRARPPWAL LHSRRYWRTV GQPEGIVSEQ DTDHHFVHRS TIPTMHFQPS LPRLPIPKLE
     DTIRRYLAAQ RPLLNDEQYR NTEKLAQEFA NGEGEFIHRD LLEHDKNNKH TSYISAPWFD
     MYLSAREPIT LNYNPFITLN PDPKSEYNTQ VVRATNLIVS SLKFLNSLKN NYLRPDIYYV
     NRRWGQSKVF KNFIRILPPT LSWYGAYMVN AYPLDMVQYK SLFNSTRIPN LNKDTLFTDE
     FARHLLVMRN GHFYIVEVLD PFGNILHPSE IQAHLIQIIH DADRLPGFEL SYLTTEERNT
     WATLRQQLVQ TGNEENLKKI DSAVFCLCLD STSPENETEL AHCFLHGNGF NRWFDKSISL
     IVTTDGMAGV NFEHSWGDGI AVLRFINEVY RDSTEHPALV PESSPALFVS SYDKLEFNLN
     RTVMSAINAA RTKFAEKTKQ LSIRSFRFEK FGKQFAVNQN LSPDAVFQLA CQMAVYRQYG
     KLRPSYEACS TAAFKHGRTE TIRPTSVYTQ KCTAAFVDER GKHSIEDMRN MIDECSRYHK
     RLQLEATLGQ GFDRHLFALK YLVQRRGGRI PDIYNDPAYK NINHIIVSTS TLSSAAVHYG
     GFGPVVPDGF GVGYNVFDNW IGCIISSYLG EDLEKLLKCL DHTLTDIFDV LEGRRLRR
//