ID G1KNV5_ANOCA Unreviewed; 1127 AA.
AC G1KNV5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 72.
DE RecName: Full=Contactin-5 {ECO:0000256|ARBA:ARBA00044127};
GN Name=CNTN5 {ECO:0000313|Ensembl:ENSACAP00000013259.4};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000013259.4, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000013259.4, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000013259.4,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000013259.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. Contactin
CC family. {ECO:0000256|ARBA:ARBA00009812}.
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DR RefSeq; XP_008106280.1; XM_008108073.1.
DR AlphaFoldDB; G1KNV5; -.
DR STRING; 28377.ENSACAP00000013259; -.
DR Ensembl; ENSACAT00000013526.4; ENSACAP00000013259.4; ENSACAG00000013104.4.
DR GeneID; 100555403; -.
DR CTD; 53942; -.
DR eggNOG; KOG3513; Eukaryota.
DR GeneTree; ENSGT00940000158183; -.
DR HOGENOM; CLU_005756_0_0_1; -.
DR InParanoid; G1KNV5; -.
DR OrthoDB; 3073820at2759; -.
DR TreeFam; TF351103; -.
DR Proteomes; UP000001646; Chromosome 3.
DR Bgee; ENSACAG00000013104; Expressed in testis and 3 other cell types or tissues.
DR GO; GO:0030424; C:axon; IBA:GO_Central.
DR GO; GO:0098982; C:GABA-ergic synapse; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0042734; C:presynaptic membrane; IEA:Ensembl.
DR GO; GO:0098632; F:cell-cell adhesion mediator activity; IBA:GO_Central.
DR GO; GO:0007411; P:axon guidance; IBA:GO_Central.
DR GO; GO:0007420; P:brain development; IBA:GO_Central.
DR GO; GO:0098609; P:cell-cell adhesion; IBA:GO_Central.
DR GO; GO:0099054; P:presynapse assembly; IEA:Ensembl.
DR GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR CDD; cd00063; FN3; 4.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR44170:SF17; CONTACTIN-5; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 3.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00409; IG; 6.
DR SMART; SM00408; IGc2; 6.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 6.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS50835; IG_LIKE; 6.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW GPI-anchor {ECO:0000256|ARBA:ARBA00022622};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00022622};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..1127
FT /note="Contactin-5"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5032474992"
FT DOMAIN 104..189
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 206..281
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 299..379
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 389..473
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 479..562
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 570..687
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 700..798
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 803..900
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 905..999
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1001..1094
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 46..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1127 AA; 123985 MW; C480E942CABCBA72 CRC64;
MQSSWRLMFF MSLASCFTES SEAIPGIPTT YAAILRLKSL SSSYSSRTRQ RSSSPPLGSI
SSPSWHGAAA QQQQQHSPTN LYHISEAFKH DESVDYGPVF IQEPDNVIFP VDSDEKKVSL
SCQARANPTP TYKWLRNGTE IEIESDYRYS VIEGSIIINN PSETKDTGLY QCITTNMFGS
ILSREATLQF AYLGNFSGRT RSAVSVREGQ GVVLMCSPPL HSPEIIYSWV FNEFPSFVAE
DSRRFISQET GNLYISKVQP SDVGSYICLV KNTVTNARVL SPPTPLTLRT DGVMGEYEPK
IEVHFPYTVT TAKGSTIKME CFALGNPVPT ISWRKVNGPN PSKARLRKSQ AVLEIPNVQL
EDAGTYECKA ENSRGRNVFR GQLQVYTYPH WTERLNDTQL DSGDQLRWEC KAIGKPRPTY
RWLKNGVPLW PESRIEMVNG VLMIHSVNQS DAGMYQCVAE NKHGAIYTSA ELRILASAPT
FPASHLKKTI IITKGQEVAV ECKPQASPKP TISWKKGDKA LRENKRITVL PDGSLRILNA
TKSDEGKYVC RGENVFGSAE ITASVFVKEP TRIDLSPKRT ELTVGESIVL SCKALHDPSL
DVIFHWTLNG QPIDFEKEGG HFESIRLSGA RAQMGSLKRM AAQTWGEAKH LQEQKQVSSA
DLMIRNILLM HAGRYGCRVQ TTADSISDEA ELLVRGPPGP PGVVIVEEIT ETTATLSWTP
GADNHSPITS YNLQARSPFS LGWQTVKTVP ETISGDMESA MAVELNPWVE YEFRVVATNK
IGTGDPSAPS RVIRTKEAVP KTAPANVSGR SGRRHELVIA WEPVSEEFQN GEGFGYIVAF
RPNGTRGWKE KMVTSSDASK FIYRDESVPP LTPFEVKVGV YNNKGDGPFS PIVVICSAEG
EPSAAPTDVK ATGLSVSEIL IAWRHNKESV GRPQGFEVGY WKDMEQEEAA EKARTEGNES
SIILTGLEGN TLYHLRVKAY NAAGYGPPSN AVRVATKKSP PSQAPSNIMW IQDGSHVSLG
WEPVRPLANE SDVMGYKVLF RQEGHSNSQV IETQKTSAVV LLPDVGVYII EVRAVSEGGD
GTPSSQIRVP SFSGGKVTSS QSSLHTFSTS SSTVTFLLVL MVPSTSW
//
