GenomeNet

Database: UniProt
Entry: G1KRA0_ANOCA
LinkDB: G1KRA0_ANOCA
Original site: G1KRA0_ANOCA 
ID   G1KRA0_ANOCA            Unreviewed;      4700 AA.
AC   G1KRA0;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 2.
DT   22-NOV-2017, entry version 45.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSACAP00000015315};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSACAP00000015315};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata;
OC   Toxicofera; Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000015315, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000015315, ECO:0000313|Proteomes:UP000001646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000015315};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACAP00000015315}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSACAP00000015315}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   STRING; 28377.ENSACAP00000015315; -.
DR   Ensembl; ENSACAT00000015626; ENSACAP00000015315; ENSACAG00000015401.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; G1KRA0; -.
DR   OMA; HDECLTI; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000001646; Chromosome 1.
DR   Bgee; ENSACAG00000015401; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0005509; F:calcium ion binding; IBA:GO_Central.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IBA:GO_Central.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 1.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001646};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4307   4331       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4539   4559       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4622   4641       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      100    155       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      162    207       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      215    272       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      280    338       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      345    402       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      594    805       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1021   1217       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1365   1575       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4044   4079       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4700 AA;  532670 MW;  932CE0F78BC48432 CRC64;
     MGSGGGGAST KIFLHKNDDE VVLQCVANIH KEQRKFCLAA EGLGNRLCFL EPTSEAKYVP
     PDLCICNFVL EQSLSVRALQ EMLANTGDNS SEGAAQGGGH RTLLYGHAIL LHHSFSGMYL
     TCLTTSRSQT DKLAFDVGLQ ENAAGEACWW TIHPASKQRS EGEKVRIGDD LILVSVSSER
     YLHLSVAYGN IQVDASFMQT LWNVHPTCSG SSIEEGYLLG GHVLRLFHGH DECLTIPSTE
     QNDSPQKSLQ KAIYESGGAG VRARSLWRVE PLRISLSWSG SNIRWAQPFR LRHITTGQFL
     ALTEDLGLVL LDREKADTKT TSFCFRASKE KLESIHKRDI EGMGVPEIKY GDSVCFVQHV
     ASSLWLTYKA QDAKTTRLGP VKRKVILHQE GHMDDGLTLQ RCQHEESQAA RIILNTTRLF
     SQFIRKTCDK FAGNNRTSSP ITLPIGEVLQ TLQDLITYFL PPEEELEHED KQNKLRSLKN
     RQNLFKEEGM LALVLNCIDR LNVYYSTAHF TGVGREENST AWKEILNLLY KLLAALIRGN
     RNNCAQFSNN LDWLISKLDR LESSSGILEA LHCILIESPE ALNLIEEGHI KSIISLLDKH
     GRNHKVLDVL CSLCLCNGVA VRANQNLICD NLLPRRDLLL QTRLVNDVTS MRPNIFLGIA
     EGSAQYKKWY FELIIDQVDP FLTAEPTHLR VGWASTSGYA PYPGGGEGWG GNGVGDDLYS
     YGFDGLHLWS GRIPRAVASV NQHLIASEDV VSCCLDLGAP SISFRINGQP VQGMFENFNI
     DGLFFPVVSF SAGVKVRFLM GGRHGEFKFL PPTGYVPCYE ALLPKEKMKL EPVKEYKRDS
     NGIRDLLGTT QFVSQANFIP CPISTSQIVL PLHLEKIRDK LAENIHELWG MNKIELGWTY
     GKIRDDNKRQ HPCLVEFSKL PETEKNYNLQ MSTETLKTLL ALGCHIVHTN PGAEEDLKKI
     KLPKNYMMSN GYKPAPLDLS EVKLLPPQEA LVDKLAENAH NVWAKDRIKQ GWTYGIQQDL
     KNKRNPRLVP YTLLDERTKK SNRDSLREAV RTFAGYGYNI EPPDQELADQ TVEKISIDKI
     RFFRVEKSYA VKTGKWYFEF EAVTGGDMRV GWARPGCRPD LELGADDQAF VFEGSKGQRW
     HEGSSFFGRN WQPGDVVGCM INLDDKSIIF TLNGELLITN KGSELAFADF EINNGLVPIC
     SLGLSQIGRM NFGRDASTFK YYTMCGLQEG FEPFAVNMNR DVAMWFSKRL PTFVNVPKNH
     SHIAVTRIDG NIDSPPRLKV THKTFGTQNS NADMIYCRLS MPIEFHSSFN YITSLELVDG
     FQKREESFSI PPLPPICKPP FKYGGKIWLE YIYISEGFGG KYGKYGNCHQ REVMSFKAQS
     EARRLIFMNN KITSLVELKI LSLEQQVRGE VPLIDQGPHQ VQEDKPKYKI NIGIIQYYYS
     VRIFAGQDPS SVWIGWVTPD YHFYSEHFNL NKNCTVTVTL GDERGRVHES VKRNNCYLVW
     GGEAAVNSQR SGRGNVDLEI GCLVELASGM LSFTANGKEL GTFYQVEPNT KLFPAVFLQP
     TSTNLFQFEL GKLKNTMPLS AAIFKSEERN PIPQCPPRLD VQTITPVVWS RMPNYFLKVD
     ADRVSDRHGW LVQCLEPLQM MALHIPEEIR CIDILELCEQ EDLMRFHFHT LKLYSSVCAL
     GNNRVAYALC SHVDISQLFY TIDNQYLPGL LRSGFYDLLI SIHLEYSKEA KLMMNNEFII
     PITDETRKIK LFPDESKRHG LPGVGLSTCL KPDFKFSTPC FILSQEDHQK PSPEIPLDML
     KSRAISMLTE AVYCSGAHIR DPVGGKVEFQ FVPVLKLIGT LLIMGVFDDH DVKQILLLID
     PYVFGEPKEE TLEKTEKEDV TQIEEKAVEA GEKAIKETKT PIKGLLQTRL TESVKLQMCE
     LLNYFCDCEL KHRVEAIVSF ADTYVSKLQY NQKYRYNELM QALNMSAALT ARKTKEFRSP
     PQEQINMLLN FQLGEDCPCP DEIREELYEF HDDLLMHCGI PLEEEEVEDK DISWAGKLRS
     LIYKIKGAPK TEVRETTEEE EKYPTTLKKL ISRTMVSWAQ EDQIQDPELV RIMFNLLRRQ
     YDSIGELLLA LRKSYTISAA SVQDTINLLA ALGQIRSLLS VRMGKEEELL MINGLGQRMR
     GQEFFLHQSF LLRRLSFPFP VYIIMTKVAN GPQSQQIAFP KMVASCCRFL CYFCRISRQN
     QKAMFEHLSY LLENSSVGLA SPSMRGSTPL DVAAASVMDN NELALALEEP DLEKVVTYLA
     GCGLQSCPML LAAGYPDTGW NPIEGERYLS FLRFAVFVNG ESVEENASVV VKLLIRRPEC
     FGPALRGEGG NGLLAAMQGA IKISENPALD LPSQGYKRDF LDEDEEEEGV VHMGNAIMSF
     YSALIDLLGR CAPEMHLIQT GKGEAIRIRS ILRSLVPTED LVGIISIPLK LPTVNKDGTV
     SEPDMSAGFC PDHKAPMVLF LDRVYGIKDQ SFLLHLLEVG FLPDLRACAS LDTVSLSTTE
     TALALNRYIC TAVFPLLTRC ASLFSGTEHY VSLIDSTLHT IYRLSKGRSL TKAQRDTIEE
     CLLAICHYLR PSMLQQLLRR LVFDVPLLNE YCKMPLKLLT NHYEQCWKYY CLPSGWGNYG
     IAAEEELHLT EKLFWGIFDS LSSKKYDPDL FRMALPCLSA IAGALPPDYL DIQIASILEK
     QTSVDAEGNF DPKPVNTVNF ILPEKLEYIV NKYAEHSHDK WACDKSNSGW KYAASVDENM
     KMHPLIRPFK TLTDKEKEIY RWPARESLKT MLAMGWSLER TKEGESTVQQ RENEKLRSVS
     QSSQDSINDT YQQGNGYNPA PLDLSNVVLS RELQGMVEIV AENYHNIWAK KKKIELESKG
     GGSHPLLVPY DTLTAKEKAR DREKAQELFR FLLVNGVAIT RKTRGLNDMA LDASSMEKRF
     AYKFLKKILK YVDSAQDFIA HLEAIVTSGK TEKSPHDQEI KFFAKVLLPL VDQYFTNHCL
     YFLSSPTKPL SSSGYASNKE KEMVASLFCK LAALVRHRIS LFGNDATTMV SCLHILAQSL
     DTRTVMKSGS ELVKAGLCAF FENAAEDLEK TSENLKLGKF THSRTQIKGV SQNINYTTVA
     LLPILTSIFE HVAQHHFGTD LLLGDVQVSC YRILCSLYSL GTGKNIYVER QRPALGECLA
     SLAAAIPVAF LEPSLNLYNP LSVFNTKTTR ERAKYEVLGI PETVEEMCPE IPNLDDLMKE
     INNLAESGAR YTEMPHVIEV TLPMLCNYLS YWWERGPENI CESAGPCCTM VTSEHLSIIL
     GNILKIINNN LGIDEATWMK RIAVYAQPII SKARPDLLKS HFIPTLEKLK KKAIKIVMEE
     EQLKADSKTD TQEAELLILD EFAVLCRDLY AFYPMLIRYV DNNRSNWLKK PDADSDELFR
     MVAEVFILWC KSHNFKREEQ NFVIQNEINN LAFLTGDNKS KMSKSGGHDQ ERKKSKRRGD
     LYSIQTSLIV AALKKMLPIG LNMCTPGDQE LISLAKSRYS YKDTEEEIKE HLRNNLHLQE
     KSDDPAVKWQ LNLYKDILKT DEPADSEKTV ERVQRISAAV YHLEQVEQPL RSKKAVWHKL
     LSKQRKRAVV ACFRMAPLYN LPRHRSINLF LHGYQKYWIE TEEYSFEEKL VQDLATLPQK
     SEEDEEEIEK HPDPLHQIIL HFSRNALTER SKLENDPLYT AYSAMMAKEK SCQSGEDDDE
     EEEEKEKTFE EKEMEKQKTL YQQSRLHERG AAEMVLQMIS ASKGEMGPMV VETLKLGIAV
     LNGGNSVVQQ KMLDYLKEKK DAGFFQSLSG LMQSCSVLDL NAFERQNKAE GLGMVTEEGT
     LIVRERGEKV LQNDEFTKDL FRFLQLLCEG HNNDFQNYLR TQMGNTTTVN IIISTVDYLL
     RLQESISDFY WYYSGKDVID DSGQRNFSKA LAVTKQIFNS LTEYIQGPCI GNQQSLAHSR
     LWDAVVGFLH VFANMQMKLS QDSSQIELLK ELLDLLKDMV VMLLSLLEGN VVNGTIGKQM
     VDTLVESSSN VEMILKFFDM FLKLKDLTSS EAFKEYDPEG KGVISKKEFQ KAMEGQKQYT
     QSEIEFLLSC AETDENDMFN YADFVERFHE PAKDIGFNVA VLLTNLSEHM PNDSRLQTLL
     DPAGSVLNYF EPYLGRIEIM GGAKKIERVY FEISESSRTQ WEKPQVKESK RQFIFDVVNE
     GGEQEKMELF VNFCEDTIFE MQLASQISES DTTDRPEEEE EDEHCYVREV GEDEKEEQSL
     ESASAFALAC ATAKKNATTI IKTIRLKNLR KQYRKVKKMT LKELVKVFFS FLWMLFIGFF
     QMLFAIIWGI FQILWSTVFG GGLVEGAKNI RVTKILGDMP DPTQFGIHDD VLESEKAEVT
     EHGITAEIVQ FVKNEKEESD ILSDIFGIHT NKESGSKHGH DIGLGDIADI IGSETPPSLE
     SAVHKKKKAQ VDKTLSEIGR DDESETRTES EKADIENGEK QDKIKDDEYS EHLEIDESKK
     RKRRRGQKIE KPDAVMANFF KVLEVYQTKM LHCLARNFYN LRFLALFVAF AINFILLFYK
     VKGTGQGECD PTGSREGGGG KGGGGGSRHH GGQALDEDED EDGVVFYVLQ ESTGYMAPTL
     RALAVIHTII SFVCVIGYYC LKVPLVVFKR EKDIARKLEF DGLYITEQPS EDDIKGQWDR
     LVINTPSFPN NYWDKFVKRK
//
DBGET integrated database retrieval system