ID G1KRX5_ANOCA Unreviewed; 950 AA.
AC G1KRX5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 73.
DE RecName: Full=Netrin receptor UNC5 {ECO:0000256|RuleBase:RU367033};
GN Name=UNC5B {ECO:0000313|Ensembl:ENSACAP00000015703.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000015703.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000015703.3, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000015703.3,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000015703.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor for netrin required for axon guidance. Mediates axon
CC repulsion of neuronal growth cones in the developing nervous system
CC upon ligand binding. {ECO:0000256|RuleBase:RU367033}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU367033}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU367033}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the unc-5 family.
CC {ECO:0000256|ARBA:ARBA00009844, ECO:0000256|RuleBase:RU367033}.
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DR STRING; 28377.ENSACAP00000015703; -.
DR Ensembl; ENSACAT00000016018.4; ENSACAP00000015703.3; ENSACAG00000015868.4.
DR Ensembl; ENSACAT00000039382.1; ENSACAP00000037328.1; ENSACAG00000015868.4.
DR eggNOG; KOG1480; Eukaryota.
DR GeneTree; ENSGT00950000182815; -.
DR HOGENOM; CLU_014383_0_0_1; -.
DR TreeFam; TF316767; -.
DR Proteomes; UP000001646; Chromosome 3.
DR Bgee; ENSACAG00000015868; Expressed in embryonic post-anal tail and 9 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005042; F:netrin receptor activity; IBA:GO_Central.
DR GO; GO:0033564; P:anterior/posterior axon guidance; IBA:GO_Central.
DR GO; GO:2001240; P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; IEA:Ensembl.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR CDD; cd08802; Death_UNC5B; 1.
DR Gene3D; 2.60.220.30; -; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR042156; Death_UNC5B.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR037936; UNC5.
DR InterPro; IPR033772; UPA.
DR InterPro; IPR000906; ZU5_dom.
DR PANTHER; PTHR12582; NETRIN RECEPTOR UNC5; 1.
DR PANTHER; PTHR12582:SF6; NETRIN RECEPTOR UNC5B; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF00090; TSP_1; 2.
DR Pfam; PF17217; UPA; 1.
DR Pfam; PF00791; ZU5; 1.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00409; IG; 1.
DR SMART; SM00408; IGc2; 1.
DR SMART; SM00209; TSP1; 2.
DR SMART; SM00218; ZU5; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 2.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS50092; TSP1; 2.
DR PROSITE; PS51145; ZU5; 1.
PE 3: Inferred from homology;
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473,
KW ECO:0000256|RuleBase:RU367033};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319,
KW ECO:0000256|RuleBase:RU367033};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367033};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU367033};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|RuleBase:RU367033};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367033};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367033}.
FT SIGNAL 1..33
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT CHAIN 34..950
FT /note="Netrin receptor UNC5"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT /id="PRO_5041474059"
FT TRANSMEM 380..405
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367033"
FT DOMAIN 167..248
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 549..692
FT /note="ZU5"
FT /evidence="ECO:0000259|PROSITE:PS51145"
FT DOMAIN 882..948
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
SQ SEQUENCE 950 AA; 105446 MW; 78735070B60EA132 CRC64;
MPPLPGIPTR LWRPRTLASL LMLLVGELSL CRAGIEYGDV LPDSFPSAPA ESLPHFLMEP
QDAYIVKNKP VELICRANPA TQIYFKCNGE WVNQNDHLTK ESVDEVTGLL VREVQIEVSR
QQVEELFGLE DYWCQCVAWS SAGTTKSRRS YVRIAYLRKN FDQEPLGKEV PLDHEVLLQC
RPPEGVPTAE VEWLKNEDLL DPSQDTNFLI TIDHNLIIKQ ARLSDTANYT CVAKNIVAKR
RSTTATIIVY VNGGWSTWSE WSLCSNRCGR GWQKRSRTCT NPAPLNGGSV CDGQSLQKLV
CTTMCPVDGA WTEWSKWSAC STECTHWRSR ECMAPSPKNG GKDCSGVLLD SKNCTDGLCM
QNKRFVSEPK SHLLEATGDV ALYAGLVVAI FIFIVILMAV GVVVYRRSCR DFDTDITDSS
AALTGGFHPV NFKTSRHDTP QLLHPSMQPD LTANAGIYRG PMYALQDSSD KIPMTNSPLL
DPLPNLKIKV YNSSTASSSP GIHEGANLLG TMPSGTFPGD NFRDNHFMNL RNKTMGSQQL
LTLPREPGNS ATGTFGCLGG RLTIPGTGVN LLVPHGAIPQ GKFYEMYLMI NKAENSLLPS
EGTQTVLSPM VTCGPTGLLL CRPVILTVPH CADVSSPDWM LQLKTQSHQG NWEEVVTLDE
ETLNTPCYCQ LEPKCCHILL EQLGTYVLVG ESYSRSAIKR LQLAIFAPTL CTSLEYSLKV
YCLEDTPDAL KEVLELEKTL GGYLLEEPKP LLFKDSYHNM RLSVHDIPHS LWRSKLLAKY
QEIPFYHIWS GSQRALHCTF TLERYSLAST ELTCKICVRQ VEGEGQIFQL HITLGENSSS
VNALCSHPGS TLTTQLGPYA FKIPLSIRHK ICNSLDAPNS RGNDWRLLAQ KLSMDRYLNF
FATKASPTGV ILDLWEAQHQ DDGDLNTLAS ALEEMGKSEM LVVMATEGDC
//
