ID G1KTF2_ANOCA Unreviewed; 397 AA.
AC G1KTF2;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 26-JUN-2013, sequence version 2.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=TIA1 cytotoxic granule associated RNA binding protein like 1 {ECO:0000313|Ensembl:ENSACAP00000016750.3};
GN Name=TIAL1 {ECO:0000313|Ensembl:ENSACAP00000016750.3};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000016750.3, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000016750.3, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000016750.3,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000016750.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_008104999.1; XM_008106792.2.
DR AlphaFoldDB; G1KTF2; -.
DR STRING; 28377.ENSACAP00000016750; -.
DR Ensembl; ENSACAT00000017080.4; ENSACAP00000016750.3; ENSACAG00000016986.4.
DR GeneID; 100563854; -.
DR KEGG; acs:100563854; -.
DR CTD; 7073; -.
DR eggNOG; KOG0148; Eukaryota.
DR GeneTree; ENSGT00940000160482; -.
DR HOGENOM; CLU_025000_2_0_1; -.
DR InParanoid; G1KTF2; -.
DR OrthoDB; 12274at2759; -.
DR TreeFam; TF312915; -.
DR Proteomes; UP000001646; Chromosome 3.
DR Bgee; ENSACAG00000016986; Expressed in adrenal gland and 14 other cell types or tissues.
DR GO; GO:0010494; C:cytoplasmic stress granule; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0035925; F:mRNA 3'-UTR AU-rich region binding; IEA:Ensembl.
DR GO; GO:0140517; F:protein-RNA adaptor activity; IEA:Ensembl.
DR GO; GO:0007281; P:germ cell development; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0035332; P:positive regulation of hippo signaling; IEA:Ensembl.
DR GO; GO:2000637; P:positive regulation of miRNA-mediated gene silencing; IEA:Ensembl.
DR GO; GO:2000648; P:positive regulation of stem cell proliferation; IEA:Ensembl.
DR GO; GO:0017145; P:stem cell division; IEA:Ensembl.
DR GO; GO:0072089; P:stem cell proliferation; IEA:Ensembl.
DR CDD; cd12616; RRM1_TIAR; 1.
DR CDD; cd12617; RRM2_TIAR; 1.
DR CDD; cd12620; RRM3_TIAR; 1.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR003954; RRM_dom_euk.
DR InterPro; IPR034492; TIAR_RRM1.
DR InterPro; IPR034494; TIAR_RRM2.
DR InterPro; IPR034496; TIAR_RRM3.
DR PANTHER; PTHR48025:SF20; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN M-RELATED; 1.
DR PANTHER; PTHR48025; OS02G0815200 PROTEIN; 1.
DR Pfam; PF00076; RRM_1; 4.
DR SMART; SM00360; RRM; 3.
DR SMART; SM00361; RRM_1; 3.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 3.
DR PROSITE; PS50102; RRM; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 8..101
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 113..191
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 221..293
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
SQ SEQUENCE 397 AA; 44020 MW; 729191625491A1B2 CRC64;
MEDDGQPKTL YVGNLSRDVT EVLILQLFSQ IGPCKSCKMI TEQPDSRRVN SSVGFSVLQH
TSNDPYCFVE FYEHRDAAAA LAAMNGRKIL GKEVKVNWAT TPSSQKKDTS NHFHVFVGDL
SPEITTEDIK SAFAPFGKIS DARVVKDMAT GKSKGYGFVS FYNKLDAENA IVHMGGQWLG
GRQIRTNWAT RKPPAPKTTQ ESTTKQLRFE DVVNQSSPKN CTVYCGGIAS GLTDQLMRQT
FSPFGQILET RAFPGKGYSF VRFSTHESAA HAIVSVNGTT IEGHVVKCYW GKESPDMTKN
FQQVDYSQWG QWSQVYGNPQ QYGQYVTNGW QVPSYGMYGQ AWNQQGFGVD QTPSAAWMSG
FGAQPAQGQA PPVIPNQAGY VFYITDFKKN DIKDAFS
//
