ID   G1KU80_ANOCA            Unreviewed;       815 AA.
AC   G1KU80;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 2.
DT   27-MAR-2024, entry version 74.
DE   SubName: Full=Potassium channel tetramerization domain containing 3 {ECO:0000313|Ensembl:ENSACAP00000017353.3};
GN   Name=KCTD3 {ECO:0000313|Ensembl:ENSACAP00000017353.3};
OS   Anolis carolinensis (Green anole) (American chameleon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC   Iguania; Dactyloidae; Anolis.
OX   NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000017353.3, ECO:0000313|Proteomes:UP000001646};
RN   [1] {ECO:0000313|Ensembl:ENSACAP00000017353.3, ECO:0000313|Proteomes:UP000001646}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000017353.3,
RC   ECO:0000313|Proteomes:UP000001646};
RG   The Genome Sequencing Platform;
RA   Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA   Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL   Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSACAP00000017353.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the KCTD3 family.
CC       {ECO:0000256|ARBA:ARBA00009572}.
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DR   RefSeq; XP_008124060.1; XM_008125853.2.
DR   AlphaFoldDB; G1KU80; -.
DR   STRING; 28377.ENSACAP00000017353; -.
DR   Ensembl; ENSACAT00000017693.4; ENSACAP00000017353.3; ENSACAG00000017622.4.
DR   GeneID; 100558255; -.
DR   KEGG; acs:100558255; -.
DR   CTD; 51133; -.
DR   eggNOG; KOG2714; Eukaryota.
DR   GeneTree; ENSGT00940000153881; -.
DR   HOGENOM; CLU_012214_1_0_1; -.
DR   InParanoid; G1KU80; -.
DR   OrthoDB; 5312378at2759; -.
DR   TreeFam; TF313754; -.
DR   Proteomes; UP000001646; Chromosome 1.
DR   Bgee; ENSACAG00000017622; Expressed in forelimb bud and 13 other cell types or tissues.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR   CDD; cd18393; BTB_POZ_SHKBP1; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR047876; SHKBP1/KCTD3.
DR   InterPro; IPR047825; SHKBP1_KCTD3_BTB_POZ.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR003131; T1-type_BTB.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR15859:SF2; BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD3; 1.
DR   PANTHER; PTHR15859; SETA BINDING PROTEIN 1; 1.
DR   Pfam; PF02214; BTB_2; 1.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00320; WD40; 3.
DR   SUPFAM; SSF54695; POZ domain; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50097; BTB; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001646};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT   DOMAIN          15..84
FT                   /note="BTB"
FT                   /evidence="ECO:0000259|PROSITE:PS50097"
FT   REGION          142..164
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          704..726
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          738..815
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        738..756
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        771..799
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   815 AA;  88965 MW;  B473F3ECCB5F65EA CRC64;
     MAGNGAGFAG AGSGEIVQLN VGGTRFSTSR QTLMWIPDSF FSSLLSGRIS TLKDETGAIF
     IDRDPAAFAP ILNFLRTKEL DLRGVSINVL RHEAEFYGIT PLVRRLLLCE ELERSSCGSV
     LFHGYLPPPG IPSRKISSSA GVSAEVRSPQ NGPEGEARGG NMQPSLAGAG EDAVRLGFPV
     DPRKVLIVAG HHNWIVAAYA HFAVCYRIKE SSGWQQVFTS PYLDWTIERV ALNAKVVGGP
     HGDKDKMVAV ASESSIILWS VQDGGSGSEI GIFSLGVPVD ALFFIGNQLV ATSHTGKVGV
     WNAVTQHWQV QDVVPITSYD TAGSFLLLGC NNGSIYYIDM QKFPLRMKDN DLLVTELYHD
     PSNDAITALS VYLTPKTSVS GNWIEIAYGT SSGAVRVIVQ HPETVGSGPQ LFQTFTVHRS
     PVTKIMLSEK HLVSVCADNN HVRTWTVTRF RGMISTQPGS TPLASFKILS LEETESHGSY
     SSGNDIGPFG ERDDQQVFIQ KVVPITNKLF VRLSSTGKRI CEIQAVDCTT ISAFTVRECE
     GSSRMGSRPR RYLFTGHVNG SIQMWDLTTA MDMVNKSEEK DVGGPTEEEL LKLLDQCDLS
     TSRCATPNIS PATSVVQQSR LRESNSSLQL QHRETIHETA TYGAIRPYRE SPLLARARRT
     ESFHSYKEIQ AFNLNKTMVD KTVPQNGNQS PVQMEVKRIS ENLSEKRVSA SPIEVRSPRT
     TDSGTEVQKI PENISEMKKR GTDEDTEVRV DNKKKSGFEG GGFLGRKKVP HLVSSSNSIV
     EGGSEALGTA SPSPTKTPVS PRHKKSDSSC QDYTV
//