ID G1KUQ1_ANOCA Unreviewed; 954 AA.
AC G1KUQ1;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 29-SEP-2021, sequence version 3.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN Name=HFM1 {ECO:0000313|Ensembl:ENSACAP00000017851.4};
OS Anolis carolinensis (Green anole) (American chameleon).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Iguania; Dactyloidae; Anolis.
OX NCBI_TaxID=28377 {ECO:0000313|Ensembl:ENSACAP00000017851.4, ECO:0000313|Proteomes:UP000001646};
RN [1] {ECO:0000313|Ensembl:ENSACAP00000017851.4, ECO:0000313|Proteomes:UP000001646}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JBL SC #1 {ECO:0000313|Ensembl:ENSACAP00000017851.4,
RC ECO:0000313|Proteomes:UP000001646};
RG The Genome Sequencing Platform;
RA Di Palma F., Alfoldi J., Heiman D., Young S., Grabherr M., Johnson J.,
RA Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Anolis carolinensis (Green Anole Lizard).";
RL Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSACAP00000017851.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
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DR AlphaFoldDB; G1KUQ1; -.
DR STRING; 28377.ENSACAP00000017851; -.
DR Ensembl; ENSACAT00000021090.4; ENSACAP00000017851.4; ENSACAG00000021072.4.
DR eggNOG; KOG0952; Eukaryota.
DR GeneTree; ENSGT00550000074822; -.
DR HOGENOM; CLU_000335_0_0_1; -.
DR InParanoid; G1KUQ1; -.
DR TreeFam; TF328936; -.
DR Proteomes; UP000001646; Chromosome 4.
DR Bgee; ENSACAG00000021072; Expressed in adrenal gland and 7 other cell types or tissues.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0000712; P:resolution of meiotic recombination intermediates; IEA:Ensembl.
DR CDD; cd18023; DEXHc_HFM1; 1.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR47835; HFM1, ATP DEPENDENT DNA HELICASE HOMOLOG; 1.
DR PANTHER; PTHR47835:SF2; SEC63 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF02889; Sec63; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00973; Sec63; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001646}.
FT DOMAIN 4..193
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 234..412
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 954 AA; 108588 MW; 3CE0AD25F11FA0E2 CRC64;
KALDDLLYTD RNFVIRAPTG SGKTVMFELA ITRLLIRVPM PWLNIKIVYM APIKALCSQR
SDDWKEKFGP IGLICKELTG DTAMDDLFEI QHAHIILTTP EKWDSMTRKW RDNSLVQLVR
LILIDEVHVV KDESRGATLE VVVSRMKTVQ SFLSCGSESS DSVLSMRFVA VSATIPNAED
IAEWLSDGKG PAICLKIDER YRPVKLRKVV LGFPCSSNQT EFKFDLTLNY KVASVIQAYS
EQKPTLVFCA TRKGVQQAAS VLAKDAKFIM NVEQLQKCAK LVKEARLREL LICGIAYHHA
GVEVSDRKII EAAFNMGDIP VLFTTSTLAM GVNLPAHLVI IKSTMHYAGG MFQEYSETDI
LQMIGRAGRP QFDTTATAVI MTRLSTRDKY VQMLNGADTI ESSLHMHLIE HLNAEVVLHT
ITDVNIALEW IRSTFLYIRA LKNPAYYGFS AGLDRNGIEE KLQELCLKNL NDLSSFDLIK
MDEKLYFKPT ETGRLMAWYY IAFDTMKNCF MIKGTETLSE LVALISSCSE FSDIKLRTNE
KKTLNTLNKD KNRPTIRYPM EGKIKTREMK VNCLIQSQLG CLPIQDFTLT QDIGKIFRSG
TRLTKWLSEF LASREYHFLV LLNSLILAKC FKCRLWENSL YVSIQLEKIG VMLSSAMMNA
GLTSFKKIED TNPREIELIL NRHPPFGSQI KESVIHLPKY ELHVEQLGNY SESVAEILVT
VMLTNFEQLQ TKRTAPDSHY VTLIIGDDDN QVVFKQKIMD SALLKIGKWT KKVEVRRAIK
SEELSINLIS SEYVGLDIQQ KFKALYLGPK VFGKQMVIRH GKLEDNNYLA SPTTKINKGT
GRQEILNRKL ANRKCNHHCK NKDGCGHDCC KIGVLQKYDM KREPVISSYL TDLRNRNAVS
TVPPVKRLKV HRCLNYWFLS FVHSLYICTQ KDSTPFLLYE NTFQEVGENN VAHI
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